Gasotransmitters


Book Description

Gasotransmitters are gas molecules produced endogenously in prokaryotic and eukaryotic cells for signalling purposes. This book provides, for the first time, a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002. The content and scope covers the production, metabolism, and signalling roles of gasotransmitters. Conceptual advances, scientific discoveries and newly developed techniques described in this book influence our understanding of fundamental molecular and cellular events in biology and medicine. This book serves as the state-of-the-art book for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicologists studying the toxic mechanisms of gasotransmitters in the environment. It will also be welcomed by researchers in university and research institutes, government agencies, pharmaceutical and medical instrument industry, and clinical practice.




Gasotransmitters Signaling in Plant Abiotic Stress


Book Description

This book deals with the gasotransmitters signaling in redox reactions and homeostasis for the adaptation of plants to unfavorable abiotic stress environments. There are lots of interesting chapters in this book that cover both research and educational objectives. This book serves as a reference illustrated book for all who are interested in the regulation of gasotransmitters and redox homeostasis in agriculture. Maintenance of redox homeostasis strengthens the potentiality of plants to resist abiotic stress conditions through the enhanced antioxidant system and the subsequent impact on other signaling molecules. The book presents novel outcomes and implications in plant biology concerning the study of different types of gasotransmitters signaling such as nitric oxide (NO), ethylene, hydrogen sulfide (H2S), etc. under diverse abiotic stresses in one place. The chapters of the book discuss the recent progress and current perspectives on the role of gasotransmitters relevance to plant functions and adaptations to abiotic stresses, the influence of gasotransmitters on the physiology of plants with respect to abiotic stress tolerance, gasotransmitters and omics for abiotic stress tolerance, advancement in the biology of gasotransmitters in regulating salinity and drought stress response in plants, new insights of gasotransmitters and cellular redox homeostasis in plants and the chapter also deliberate the emerging role of gasotransmitters in regulating redox homeostasis for plant stress management. This book is the first comprehensive book covering all aspects and advancements in the biology of gasotransmitters in redox homeostasis conferring different abiotic stress tolerance, from which readers from all backgrounds can get benefitted. This book will appeal to researchers, students, scientific societies, agriculturists, etc.







Gasotransmitters: Physiology and Pathophysiology


Book Description

Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters.




Signal Transduction and the Gasotransmitters


Book Description

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.




Gasotransmitters in Plants


Book Description

This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants. Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked by exogenous application; and their cellular effects may or may not be mediated by second messengers, but have specific cellular and molecular targets. In plants, many aspects of the biology of gasotransmitters remain completely unknown and generate intriguing questions, which will be discussed in this book.




Gasotransmitters Signaling in Plants under Challenging Environment


Book Description

Abiotic stressors, such as drought, extreme temperatures, heavy metals, or high salinity, are causing huge crop losses worldwide. These abiotic stressors are expected to become more extreme, less predictable, and more widespread in the near future. The harm of abiotic stresses includes the disruption of cellular redox homeostasis, reactive oxygen species (ROS) production, and oxidative stress in the plant. Plants have different mechanisms to fight stress, and these mechanisms are responsible for maintaining the required homeostasis in plants. Research on gasotransmitters is rapidly expanding and knowledge regarding the potential of gasotransmitters in biology and medicine is accumulating. Over the past few decades, the roles of these signaling molecules, especially NO and H2S, have been extensively studied for their application in plants. Recently, the emissions of endogenous gasotransmitters in plants have been widely studied and analyzed, thereby providing information to facilitate our understanding of new gasotransmitters signaling pathways. Given the multidimensional role of these signaling molecules, research over the past decades in mitigating abiotic stresses in plant biology and from an agriculture point of view, we intend to bring forth a comprehensive volume “Gasotransmitters Signaling in Plants under Challenging Environment". We are hopeful that this comprehensive volume will furnish the requisite of all those who are working or have an interest in the proposed topic




The Role of Gasotransmitters In the Amelioration of Arsenic Toxicity in Plants


Book Description

The Role of Gasotransmitters In the Amelioration of Arsenic Toxicity in Plants: Biology and Biotechnology, in the Plant Gasotransmitter series, provides research on how gasotransmitters can reduce the stress faced by plants through arsenic contamination. With a strong focus on metabolic processes, the book presents the various pathways and mechanisms associated with gasotransmitters as part of arsenic amelioration. Initial chapters discuss the effects of arsenic on the plant genome and metabolome, as well as the mechanisms behind the uptake and translocation of arsenic in plants. The book then takes a deep dive into the role of gasotransmitters, highlighting plant physiological responses. This is an essential resource for students, researchers and agronomists interested in plant physiology, biochemistry and plant hormones. - Explains the physiological, biochemical and molecular aspects of how gasotransmitters can mitigate stress by arsenic in plants - Presents how arsenic is found in the environment, along with associated problems with arsenic contamination - Highlights the impact of food processing on minimizing arsenic and other potentially toxic elements in edible plants




Gasotransmitters: novel regulators of ion channels and transporters


Book Description

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Racing for the Surface


Book Description

This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.