Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine


Book Description

This book has been written in response to the many physicians and scien tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.




Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine


Book Description

This book has been written in response to the many physicians and scien- tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.




Football Traumatology


Book Description

Football is probably the most widespread sport in the world: youngsters, adults, women, amateurs, beginners, professionals all make up a legion of practitioners. Lesions associated with football are on the increase and their typology has also changed over the years. Football, like many other sports, has undergone major changes: the increase in the intensity and speed of the game, the modern training methodologies, the technical and tactical innovations are all factors contributing to increased risks of traumatic injury. The footballers, the trainers, the sport's medical staff are asking for greater information and knowledge on the traumatic lesions associated with this sport. The primary role of those who are concerned with the health of footballers is to enforce preventive measures to reduce wherever possible the risks of trauma.




Rehabilitation for the Postsurgical Orthopedic Patient


Book Description

With detailed descriptions of orthopedic surgeries, Rehabilitation for the Postsurgical Orthopedic Patient, 3rd Edition provides current, evidence-based guidelines to designing effective rehabilitation strategies. Coverage of each condition includes an overview of the orthopedic patient's entire course of treatment from pre- to post-surgery. For each phase of rehabilitation, this book describes the postoperative timeline, the goals, potential complications and precautions, and appropriate therapeutic procedures. New to this edition are a full-color design and new chapters on disc replacement, cartilage replacement, hallux valgus, and transitioning the running athlete. Edited by Lisa Maxey and Jim Magnusson, and with chapters written by both surgeons and physical therapists, Rehabilitation for the Postsurgical Orthopedic Patient provides valuable insights into the use of physical therapy in the rehabilitation process. Comprehensive, evidence-based coverage provides an overview of the orthopedic patient's entire course of treatment from pre- to post-surgery, including a detailed look at the surgical procedures and therapy guidelines that can be used to design the appropriate rehabilitation programs. Case study vignettes with critical thinking questions help you develop critical reasoning skills. Indications and considerations for surgery describe the mechanics of the injury and the repair process so you can plan an effective rehabilitation program. Therapy guidelines cover each phase of rehabilitation with specifics as to the expected time span and goals for each phase. Evidence-based coverage includes the latest clinical research to support treatment decisions. Overview of soft tissue and bone healing considerations after surgery helps you understand the rationale behind the timelines for the various physical therapy guidelines. A Troubleshooting section in each chapter details potential pitfalls in the recovery from each procedure. Over 300 photos and line drawings depict concepts, procedures, and rehabilitation. Detailed tables break down therapy guidelines and treatment options for quick reference. Expert contributors include surgeons describing the indications and considerations for surgery as well as the surgery itself, and physical or occupational therapists discussing therapy guidelines. New coverage of current orthopedic surgeries and rehabilitation includes topics such as disc replacement, cartilage replacement, hallux valgus, and transitioning the running athlete. New full-color design and illustrations visually reinforce the content. Updated Suggested Home Maintenance boxes in every chapter provide guidance for patients returning home. References linked to MEDLINE abstracts make it easy to access evidence-based information for better clinical decision-making.




Magnetic Resonance Imaging in Orthopedic Sports Medicine


Book Description

This uniquely interdisciplinary book is a practical resource on orthopedic MR imaging that bridges the backgrounds of radiologists and orthopedic surgeons. Radiologists learn why surgeons order imaging studies. They also learn terminology that will help them tailor reports to the specialty. Orthopedic surgeons gain insight on when to order an MRI, how MRI affects decision making, and how to interpret images. Case studies also depict key clinical and exam points, supplemented by MR images and illustrations. Shorter sections highlight other anatomical areas, and additional chapters address diagnostic accuracy and imaging pitfalls.




Scaffolding In Tissue Engineering


Book Description

The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.




Biomaterials Science


Book Description

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. - Provides comprehensive coverage of principles and applications of all classes of biomaterials - Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics - Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field - Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites - Endorsed by the Society for Biomaterials




DeLee and Drez's Orthopaedic Sports Medicine E-Book


Book Description

Here's the New Edition of the must-have reference in sports medicine! Covering all athletes throughout their lifespan, this 2-volume reference explores the pathophysiology, diagnosis, and treatment of the full spectrum of sports-related injuries and medical disorders. It provides the most clinically focused, comprehensive guidance available in any single source, with contributions from the most respected authorities in the field. Thoroughly revised and updated, you’ll find state-of-the-art coverage in an all-new full-color format and access to the complete contents online, with video clips and more! Encompasses imaging techniques, the management of both adult and child/adolescent injuries, and sports-related fractures to help you meet for every clinical challenge. Includes coverage of important non-orthopaedic conditions in the management of the athlete for a complete guide to treatment. Integrates coverage of pediatric and aging athletes to help you meet the unique needs of these patients. Covers rehabilitation and other therapeutic modalities in the context of return to play. lDelivers new and expanded coverage of arthroscopic techniques, including ACL reconstruction, allograft cartilage transplantation, rotator cuff repair, and complications in athletes, as well as injury prevention, nutrition, pharmacology, and psychology in sports. Offers unprecedented reference power with access to the full text online, with links to PubMed, an image library, self-assessment material, and more. Includes video clips demonstrating arthroscopic and open surgical techniques on the website to enhance your mastery of essential skills. Offers a new full-color design and format including over 3000 superb illustrations, intraoperative and clinical photos, and boxed and color-coded text features to clarify key concepts, diagnostic landmarks, and operative techniques.




Sports Injuries


Book Description

Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation covers the whole field of sports injuries and is an up-to-date guide for the diagnosis and treatment of the full range of sports injuries. The work pays detailed attention to biomechanics and injury prevention, examines the emerging treatment role of current strategies and evaluates sports injuries of each part of musculoskeletal system. In addition, pediatric sports injuries, extreme sports injuries, the role of physiotherapy, and future developments are extensively discussed. All those who are involved in the care of patients with sports injuries will find this textbook to be an invaluable, comprehensive, and up-to-date reference.




Orthopedic Sports Medicine


Book Description

Aim of this book is to give an update on the main issues in sports traumatology and orthopedics, involving different body sections. Exploring the most important aspects of sports medicine - from anatomy to normal movements description, from diagnosis to sports injuries treatment, from conservative to surgical treatments - it gives a global overview of the field, describing also diagnostic tools recently introduced in this field, such as hip arthroscopy, and taking into consideration related areas like nutrition, prevention, training and rehabilitation. The single chapters deal with relevant problems such as emergencies on the field, pathologies of the upper and lower extremity, spine problems in athletes. Each injury is approached on the basis of both the specific body area and of the different sports/activities. Written by a multidisciplinary team of experts, this volume will be a fundamental book for orthopedic surgeons, physiotherapists, general practitioners, personal and athletic trainers, offering them a useful tool for the management of most frequent injuries in sports medicine.