General Genetics
Author : M. J. Sirks
Publisher : Springer Science & Business Media
Page : 641 pages
File Size : 18,77 MB
Release : 2013-06-29
Category : Science
ISBN : 9401575878
Genetics of Bone Biology and Skeletal Disease
Author : Rajesh V. Thakker
Publisher : Academic Press
Page : 880 pages
File Size : 10,73 MB
Release : 2017-10-31
Category : Science
ISBN : 0128041986
Book Description
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
General Genetics
Author : Adrian M. Srb
Publisher :
Page : 574 pages
File Size : 43,41 MB
Release : 1965
Category : Science
ISBN :
Book Description
Mendelism. Sex chromosomes and sex linkage; probability. The vehicles of inheritance. Life cycles and reproduction. The chemical basis of heredity. Linkage, crossing over, and chromosome mapping. Variations in genome structure. Mutation. Gene structure. Gene function. Extrachromosomal and epigenetic systems. The role of genes in development. Genes in populations. Quantitative inheritance. Genetics and man.
A History of Genetics
Author : Alfred Henry Sturtevant
Publisher : CSHL Press
Page : 190 pages
File Size : 29,49 MB
Release : 2001
Category : Medical
ISBN : 9780879696078
Book Description
In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map.
GENERAL BIOLOGY I
Author : Dennis Holley
Publisher : Dog Ear Publishing
Page : 408 pages
File Size : 30,79 MB
Release : 2017-05-31
Category : Science
ISBN : 1457552744
Book Description
GENERAL BIOLOGY: Investigating Life is an introductory level college biology textbook that provides students with an accessible and engaging look at the fundamentals of biology. Written for a two-term, undergraduate course of mixed majors and non-majors, this reader-friendly text is concept driven vs. terminology driven. That is, the text is based on the underlying concepts and principles of biology rather than strict memorization of terminology. Written in a student-centered, conversational style, this educational research-based textbook uniquely connects students and our society to living things from various perspectives—economic, ecologic, medical, and cultural, exploring how the biological world and human realm are intimately intertwined. End-of-chapter questions challenge students to think critically and creatively while incorporating science process skills and biological principles.
The Genetics of Cancer
Author : B.A. Ponder
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 11,35 MB
Release : 2012-12-06
Category : Medical
ISBN : 9401106770
Book Description
It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 16,87 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Book Description
G is for Genes
Author : Kathryn Asbury
Publisher : John Wiley & Sons
Page : 174 pages
File Size : 17,79 MB
Release : 2013-09-04
Category : Psychology
ISBN : 1118482808
Book Description
G is for Genes shows how a dialogue between geneticists and educationalists can have beneficial results for the education of all children—and can also benefit schools, teachers, and society at large. Draws on behavioral genetic research from around the world, including the UK-based Twins’ Early Development Study (TEDS), one of the largest twin studies in the world Offers a unique viewpoint by bringing together genetics and education, disciplines with a historically difficult relationship Shows that genetic influence is not the same as genetic determinism and that the environment matters at least as much as genes Designed to spark a public debate about what naturally-occurring individual differences mean for education and equality
Introduction to Veterinary Genetics
Author : Frank W. Nicholas
Publisher : John Wiley & Sons
Page : 329 pages
File Size : 46,27 MB
Release : 2013-05-30
Category : Medical
ISBN : 1118697588
Book Description
The concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals. They are also crucial to enhancing animal production. Accessible and clearly presented, Introduction to Veterinary Genetics provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students. Coverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders. This book describes in detail how genetics is being applied to artificial selection in animal production. It also covers the conservation of genetic diversity in both domesticated and wild animals. New for the Third Edition: End-of-chapter summaries provide quick recaps. Covers new topics: epigenetics, genomics and bioinformatics. Thoroughly revised according to recent advances in genetics. Introduction to Veterinary Genetics is still the only introductory genetics textbook for students of veterinary and animal science and will continue to be an indispensable reference tool for veterinary students and practitioners alike.
Genomics of Rare Diseases
Author : Claudia Gonzaga-Jauregui
Publisher : Academic Press
Page : 318 pages
File Size : 11,72 MB
Release : 2021-06-12
Category : Medical
ISBN : 0128204362
Book Description
Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians
