Genetics and Dental Health


Book Description




The Overlooked Individual: Susceptibility to Dental Caries, Erosive Tooth Wear and Amelogenesis


Book Description

Individual susceptibility to disease (i.e., one's own genetic background) is one of the three main components classically described in the etiology of dental caries. Hence, genes influence susceptibility to erosive tooth wear, dental development, and response to treatments and interventions. This publication is an up-to-date overview of individual susceptibility to dental caries, erosive tooth wear, and disturbances of dental development from different clinically relevant perspectives. One of the most recognized scientists in this field reports on recent research relating to human genetics - from general summaries to recommendations for daily clinical work and population-level interventions. This book covers all aspects of individual susceptibility to dental caries and erosive tooth wear. Several chapters deal with potential biological mechanisms, with additional ones providing a strong foundation in human genetics, and other chapters touch on efficacy of therapies and alternative concepts. This book is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on dental caries and erosive tooth wear.




Genetic Basis of Oral Health Conditions


Book Description

This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. A sound grasp of this framework is ever more important, given the emergence of consumer genomics, including direct-to-consumer genetic testing. Dental professionals now need to understand why one person is susceptible to a particular oral health condition while a first-degree relative either does not develop the condition or does so in a less severe form. Knowledge of how genes operate in the susceptible host is essential if patients are to be offered accurate advice about their risks. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies. It will enable the practitioner to explain the extent to which a patient’s condition is pure "bad luck", whether that bad luck can be changed by behavioral choices, and how many of our behaviors are influenced by genes.




Genetics of Dental Caries


Book Description

Oftentimes dentists have patients who continuously have issues with dental caries. These patients follow the advice of dentists by properly brushing and flossing their teeth, as well as adjusting their diets to aid in the maintenance of their teeth. However, these precautions patients adhere to are not universally successful; many still find themselves susceptible to frequent dental caries. Therefore, it is important to understand the genetic underpinnings to explain why some are more prone to dental caries than others. This knowledge can further be applied in researching targeted gene therapies to prevent dental caries formation, while simultaneously altering the standard treatment plan. There has been promising therapeutic research to select genes for strong enamel growth and healthy saliva, as well as genes that attack and prevent bacteria in the mouth. The usage of gene therapy is subject to controversy in Jewish law. However, these specific therapies should escape this controversy, as there is a health motivation for its allowance. Both Judaism and science mutually agree that maintaining proper oral care is crucial to the health of the mouth.




Genetic Basis of Oral Health Conditions


Book Description

This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. A sound grasp of this framework is ever more important, given the emergence of consumer genomics, including direct-to-consumer genetic testing. Dental professionals now need to understand why one person is susceptible to a particular oral health condition while a first-degree relative either does not develop the condition or does so in a less severe form. Knowledge of how genes operate in the susceptible host is essential if patients are to be offered accurate advice about their risks. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies. It will enable the practitioner to explain the extent to which a patient’s condition is pure "bad luck", whether that bad luck can be changed by behavioral choices, and how many of our behaviors are influenced by genes.













Perspectives in Genetic and Epigenetic Regulatory Mechanisms in Dental and Craniofacial Biology


Book Description

Genetic factors have been proved to be involved in almost all dental and craniomaxillofacial diseases. Typical dental and craniomaxillofacial hereditary diseases refer to hereditary diseases which occurs in the oral and maxillofacial area, as well as systemic or other system hereditary diseases accompanied by oral abnormality. The former includes enamel hypoplasia, dentin hypoplasia and cleft lip and palate, which mainly occur in the oral cavity. While the latter commonly includes cranial clavicle hypoplasia, congenital ectodermal hypoplasia, osteogenesis imperfecta, and osteosclerosis. In addition, common diseases that appear locally in the oral cavity, including caries, periodontitis, oral mucosal diseases and head and neck tumors, are also considered to be related to genetic variations. With the increase of large-scale genome-wide association analysis study (GWAS) during the last decade, common loci for many genetic diseases have been identified. To date, most evidence comes from GWAS of dental caries and periodontal disease, which have tested associations between millions of single nucleotide polymorphisms (SNPs) and typical binary phenotypes. However, genetic loci for other rare oral diseases remain to be studied due to their large variety and low incidence. Multi-omics sequencing technology provides a more powerful tool for identifying the pathogenic genes of dental and craniomaxillofacial hereditary diseases at genomic, transcriptomic and proteomic level. In addition, with the development of single-cell multi-omics technology, specific cell populations involved in the pathogenesis of dental and craniomaxillofacial hereditary disease can be more accurately identified at single-cell resolution.




Dental Caries


Book Description

Authoritative and comprehensive resource on the disease process and clinical management of dental caries. Dental Caries: The Disease and Its Clinical Management, 4th Edition maintains the same focus on high-level coverage of the disease etiology and process, clinical assessment and prognosis and wider public health issues connected with dental caries management, including an enhanced focus on caries control. Fully updated throughout, the chapters that discuss theory emphasize how the knowledge can be applied in both the clinic and in the public health domain to improve oral health. The new edition also includes up-to-date and validated diagnostic and management options for caries whilst ensuring that the tools provided allow practitioners to serve the needs of different socio-economic populations. All sections are complimented by high-quality color photographs, clear line drawings and references for further study. With contributions from international experts in research and clinical practice, Dental Caries includes information on: Acquisition and establishment of the oral microbiome, metabolism of the microbiome in caries, and the essential role of saliva for dental caries and erosion Initiation and progression of dental caries in dental hard tissues and the relationship between sugar, diets, and dental caries The caries control concept and consequences for minimally invasive management of caries Caries control in children, adults, and the elderly, including root surface caries and oral health care in the elderly Implication of caries control for the dental profession, including best practices for assessment of lesion activity, prognosis and risk for developing dental caries Dental Caries, Fourth Edition is an unrivaled guide to tooth decay, and a must-have resource for undergraduate and postgraduate students in dental public health, paediatric and restorative dentistry as well as all practitioners looking to develop their clinical skills.