Predictive Modeling of Drug Sensitivity


Book Description

Predictive Modeling of Drug Sensitivity gives an overview of drug sensitivity modeling for personalized medicine that includes data characterizations, modeling techniques, applications, and research challenges. It covers the major mathematical techniques used for modeling drug sensitivity, and includes the requisite biological knowledge to guide a user to apply the mathematical tools in different biological scenarios. This book is an ideal reference for computer scientists, engineers, computational biologists, and mathematicians who want to understand and apply multiple approaches and methods to drug sensitivity modeling. The reader will learn a broad range of mathematical and computational techniques applied to the modeling of drug sensitivity, biological concepts, and measurement techniques crucial to drug sensitivity modeling, how to design a combination of drugs under different constraints, and the applications of drug sensitivity prediction methodologies. - Applies mathematical and computational approaches to biological problems - Covers all aspects of drug sensitivity modeling, starting from initial data generation to final experimental validation - Includes the latest results on drug sensitivity modeling that is based on updated research findings - Provides information on existing data and software resources for applying the mathematical and computational tools available




Logic Synthesis for Genetic Diseases


Book Description

This book brings to bear a body of logic synthesis techniques, in order to contribute to the analysis and control of Boolean Networks (BN) for modeling genetic diseases such as cancer. The authors provide several VLSI logic techniques to model the genetic disease behavior as a BN, with powerful implicit enumeration techniques. Coverage also includes techniques from VLSI testing to control a faulty BN, transforming its behavior to a healthy BN, potentially aiding in efforts to find the best candidates for treatment of genetic diseases.




Biotechnology: Concepts, Methodologies, Tools, and Applications


Book Description

Biotechnology can be defined as the manipulation of biological process, systems, and organisms in the production of various products. With applications in a number of fields such as biomedical, chemical, mechanical, and civil engineering, research on the development of biologically inspired materials is essential to further advancement. Biotechnology: Concepts, Methodologies, Tools, and Applications is a vital reference source for the latest research findings on the application of biotechnology in medicine, engineering, agriculture, food production, and other areas. It also examines the economic impacts of biotechnology use. Highlighting a range of topics such as pharmacogenomics, biomedical engineering, and bioinformatics, this multi-volume book is ideally designed for engineers, pharmacists, medical professionals, practitioners, academicians, and researchers interested in the applications of biotechnology.




Computational Advancement in Communication Circuits and Systems


Book Description

This book comprises the proceedings of 1st International Conference on Computational Advancement in Communication Circuits and Systems (ICCACCS 2014) organized by Narula Institute of Technology under the patronage of JIS group, affiliated to West Bengal University of Technology. The conference was supported by Technical Education Quality Improvement Program (TEQIP), New Delhi, India and had technical collaboration with IEEE Kolkata Section, along with publication partner by Springer. The book contains 62 refereed papers that aim to highlight new theoretical and experimental findings in the field of Electronics and communication engineering including interdisciplinary fields like Advanced Computing, Pattern Recognition and Analysis, Signal and Image Processing. The proceedings cover the principles, techniques and applications in microwave & devices, communication & networking, signal & image processing, and computations & mathematics & control. The proceedings reflect the conference’s emphasis on strong methodological approaches and focus on applications within the domain of Computational Advancement in Communication Circuits and Systems. The content also emphasizes the emerging technologies in the Electronics and Communication field together in close examinations of practices, problems and trends.




Recent Advances in Data Mining of Enterprise Data


Book Description

The main goal of the new field of data mining is the analysis of large and complex datasets. Some very important datasets may be derived from business and industrial activities. This kind of data is known as OC enterprise dataOCO. The common characteristic of such datasets is that the analyst wishes to analyze them for the purpose of designing a more cost-effective strategy for optimizing some type of performance measure, such as reducing production time, improving quality, eliminating wastes, or maximizing profit. Data in this category may describe different scheduling scenarios in a manufacturing environment, quality control of some process, fault diagnosis in the operation of a machine or process, risk analysis when issuing credit to applicants, management of supply chains in a manufacturing system, or data for business related decision-making. Sample Chapter(s). Foreword (37 KB). Chapter 1: Enterprise Data Mining: A Review and Research Directions (655 KB). Contents: Enterprise Data Mining: A Review and Research Directions (T W Liao); Application and Comparison of Classification Techniques in Controlling Credit Risk (L Yu et al.); Predictive Classification with Imbalanced Enterprise Data (S Daskalaki et al.); Data Mining Applications of Process Platform Formation for High Variety Production (J Jiao & L Zhang); Multivariate Control Charts from a Data Mining Perspective (G C Porzio & G Ragozini); Maintenance Planning Using Enterprise Data Mining (L P Khoo et al.); Mining Images of Cell-Based Assays (P Perner); Support Vector Machines and Applications (T B Trafalis & O O Oladunni); A Survey of Manifold-Based Learning Methods (X Huo et al.); and other papers. Readership: Graduate students in engineering, computer science, and business schools; researchers and practioners of data mining with emphazis of enterprise data mining."




Emerging Research in the Analysis and Modeling of Gene Regulatory Networks


Book Description

While technological advancements have been critical in allowing researchers to obtain more and better quality data about cellular processes and signals, the design and practical application of computational models of genomic regulation continues to be a challenge. Emerging Research in the Analysis and Modeling of Gene Regulatory Networks presents a compilation of recent and emerging research topics addressing the design and use of technology in the study and simulation of genomic regulation. Exploring both theoretical and practical topics, this publication is an essential reference source for students, professionals, and researchers working in the fields of genomics, molecular biology, bioinformatics, and drug development.







Intrusion


Book Description

'Insightful and ingenious . . . Intrusion is both horrific and comic, and deals movingly with the consequences of genetic fixes' - GUARDIAN 'Intrusion is a finely-tuned, in-your-face argument of a novel . . . MacLeod will push your buttons - and make you think' - SFX Imagine a near-future city, say London, where medical science has advanced beyond our own and a single-dose pill has been developed that, taken when pregnant, eradicates many common genetic defects from an unborn child. Hope Morrison, mother of a hyperactive four-year-old, is expecting her second child. She refuses to take The Fix, as the pill is known. This divides her family and friends and puts her and her husband in danger of imprisonment or worse. Is her decision a private matter of individual choice, or is it tantamount to willful neglect of her unborn child? A plausible and original novel with sinister echoes of 1984 and Brave New World. Books by Ken MacLeod: Fall Revolution The Star Fraction The Stone Canal The Cassini Division The Sky Road Engines of Light Cosmonaut Keep Dark Light Engine City Corporation Wars Trilogy Dissidence Insurgence Emergence Novels The Human Front Newton's Wake Learning the World The Execution Channel The Restoration Game Intrusion Descent




Applied Intelligent Systems


Book Description

Humans have always been hopeless at predicting the future...most people now generally agree that the margin of viability in prophecy appears to be 1 ten years. Even sophisticated research endeavours in this arena tend to go 2 off the rails after a decade or so. The computer industry has been particularly prone to bold (and often way off the mark) predictions, for example: ‘I think there is a world market for maybe five computers’ Thomas J. Watson, IBM Chairman (1943), ‘I have traveled the length and breadth of this country and talked with the best people, and I can assure you that data processing is a fad that won’t last out the year’ Prentice Hall Editor (1957), ‘There is no reason why anyone would want a computer in their home’ Ken Olsen, founder of DEC (1977) and ‘640K ought to be enough for anybody’ Bill Gates, CEO Microsoft (1981). 3 The field of Artificial Intelligence – right from its inception – has been particularly plagued by ‘bold prediction syndrome’, and often by leading practitioners who should know better. AI has received a lot of bad press 4 over the decades, and a lot of it deservedly so. How often have we groaned in despair at the latest ‘by the year-20xx, we will all have...(insert your own particular ‘hobby horse’ here – e. g.




Knowledge Discovery in Proteomics


Book Description

Multi-modal representations, the lack of complete and consistent domain theories, rapid evolution of domain knowledge, high dimensionality, and large amounts of missing information - these are challenges inherent in modern proteomics. As our understanding of protein structure and function becomes ever more complicated, we have reached a point where