Author : Ajit Varki
Publisher : CSHL Press
Page : 694 pages
File Size : 47,5 MB
Release : 1999
Category : Medical
ISBN : 9780879696818
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author :
Publisher : Academic Press
Page : 418 pages
File Size : 49,13 MB
Release : 2015-02-26
Category : Science
ISBN : 0128016140
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students
Author : Minoru Fukuda
Publisher : CRC Press
Page : 342 pages
File Size : 34,26 MB
Release : 1991-12-13
Category : Science
ISBN : 9780849364358
Cell Surface Carbohydrates and Cell Development summarizes knowledge on the structure and function of cell surface carbohydrates in development and differentiation. The chapters include reviews on the expression of cell type-specific carbohydrates and their roles in cell-cell interaction. In particular, the role of cell surface carbohydrates in immune cell response, malignant transformation, fertilization, and neural cell development are addressed. This includes the exciting discovery about the role of adhesive molecules in leukocyte-endothellium interaction. Cell Surface Carbohydrates and Cell Development also summarizes the latest knowledge on structure and biosynthesis of carbohydrates, the role of specific carbohydrate modification, and animal lectins. The book will be useful to researchers and students interested in the biology of glycoproteins and biotechnology.
Author : National Research Council
Publisher : National Academies Press
Page : 171 pages
File Size : 43,9 MB
Release : 2012-10-23
Category : Science
ISBN : 0309260868
A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Author : Marija Pezer
Publisher : Springer Nature
Page : 588 pages
File Size : 45,75 MB
Release : 2021-10-22
Category : Medical
ISBN : 3030769127
This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Enrico Mihich
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 14,66 MB
Release : 2013-06-29
Category : Medical
ISBN : 1489913521
The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het erogeneity of tumor cell populations and tumor cell differentiation, on interactions be tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media tion of gene products. Important methodologies that would allow scientists to measure dif ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu tions and their participation in the spirited discussions that followed. We would also like to thank Drs.
Author : Gordan Lauc
Publisher : Springer Nature
Page : 392 pages
File Size : 45,40 MB
Release : 2021-09-08
Category : Science
ISBN : 3030701158
Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
Author : Koichi Furukawa
Publisher : Springer
Page : 218 pages
File Size : 18,24 MB
Release : 2016-01-26
Category : Science
ISBN : 4431559396
This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell signals, have been elucidated in a wide variety of biological events. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research.
Author : Inka Brockhausen
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 43,46 MB
Release : 2013-11-21
Category : Science
ISBN : 3662219603
Diverse alterations of glycosylation occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex rearrangements of the oligosaccharide assembly by glycosyltransferases. This volume reviews several mechanisms that may underly the extremely complex alterations in disease. Disease specific glycosylation may contribute to the disease process by altering cellular functions, or may be exploited therapeutically. Specific therapy may be aimed at correcting glycosylation abnormalities based on knowledge of the mechanisms leading to the disease phenotype and the three-dimensional interactions between carbohydrates and carbohydrate-binding molecules.
Author : Jennie R. Lill
Publisher : John Wiley & Sons
Page : 378 pages
File Size : 30,50 MB
Release : 2017-08-14
Category : Science
ISBN : 1119053102
The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
