Guidance on Pfas Exposure, Testing, and Clinical Follow-Up


Book Description

In thousands of communities across the United States, drinking water is contaminated with chemicals known as perfluoroalkyl and polyfluoroalkyl substances (PFAS). PFAS are used in a wide range of products, such as non-stick cookware, water and stain repellent fabrics, and fire-fighting foam, because they have properties that repel oil and water, reduce friction, and resist temperature changes. PFAS can leak into the environment where they are made, used, disposed of, or spilled. PFAS exposure has been linked to a number of adverse health effects including certain cancers, thyroid dysfunction, changes in cholesterol, and small reductions in birth weight. This report recommends that the Centers for Disease Control and Prevention (CDC) update its clinical guidance to advise clinicians to offer PFAS blood testing to patients who are likely to have a history of elevated exposure, such as those with occupational exposures or those who live in areas known to be contaminated. If testing reveals PFAS levels associated with an increased risk of adverse effects, patients should receive regular screenings and monitoring for these and other health impacts. Guidance on PFAS Exposure, Testing, and Clinical Follow-Up recommends that the CDC, Agency for Toxic Substances and Disease Registry (ATSDR), and public health departments support clinicians by creating educational materials on PFAS exposure, potential health effects, the limitations of testing, and the benefits and harms of testing.




Guidance on PFAS Exposure, Testing, and Clinical Follow-up


Book Description

In thousands of communities across the United States, drinking water is contaminated with chemicals known as perfluoroalkyl and polyfluoroalkyl substances (PFAS). PFAS are used in a wide range of products, such as non-stick cookware, water and stain repellent fabrics, and fire-fighting foam, because they have properties that repel oil and water, reduce friction, and resist temperature changes. PFAS can leak into the environment where they are made, used, disposed of, or spilled. PFAS exposure has been linked to a number of adverse health effects including certain cancers, thyroid dysfunction, changes in cholesterol, and small reductions in birth weight. This report recommends that the Centers for Disease Control and Prevention (CDC) update its clinical guidance to advise clinicians to offer PFAS blood testing to patients who are likely to have a history of elevated exposure, such as those with occupational exposures or those who live in areas known to be contaminated. If testing reveals PFAS levels associated with an increased risk of adverse effects, patients should receive regular screenings and monitoring for these and other health impacts. Guidance on PFAS Exposure, Testing, and Clinical Follow-Up recommends that the CDC, Agency for Toxic Substances and Disease Registry (ATSDR), and public health departments support clinicians by creating educational materials on PFAS exposure, potential health effects, the limitations of testing, and the benefits and harms of testing.




Human Biomonitoring for Environmental Chemicals


Book Description

Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.




Perfluoroalkyl Substances in the Environment


Book Description

Per- and polyfluorinated alkyl substances (PFAS), often referred to as per- (and poly) fluorinated compounds (PFCs), have been used for years in many everyday3⁄4 and some lifesaving3⁄4 products. However, their use has been linked to adverse health effects in humans, a problem compounded by their persistence in the environment. This book discusses the various challenges of PFAS in our environment today, including their historical use as well as their chemical and toxicological properties. It also presents robust discussion of analytical challenges and special considerations in sampling. The work goes on to give practical recommendations for dealing with these compounds in today's dynamic regulatory landscape and includes several chapters on various remediation techniques. Key Features: Comprehensive overview of per- and polyfluorinated alkyl substances (PFAS) historical use and chemical/physical properties which help us understand their persistence, transport, and transformation pathways in the environment In-depth analysis of PFAS toxicology Detailed descriptions of conventional and state-of-the-art remediation technologies Practical recommendations for dealing with PFAS in a dynamic regulatory landscape Robust discussion of important sampling and analytical considerations Perfluoroalkyl Substances in the Environment: Theory, Practice, and Innovation explores the challenges across the topical areas of regulation and management, toxicology, environmental remediation, and analytical sampling and analysis.Readers will find this text helpful in understanding complexities associated with PFAS and informing management strategies to effectively protect this and future generations.




Use and Potential Impacts of AFFF Containing PFASs at Airports


Book Description

TRB's Airport Cooperative Research Program (ACRP) Research Report 173: Use and Potential Impacts of AFFF Containing PFASs at Airports explores the potential environmental and health impacts of per- and polyfluoroalkyl substances (PFASs) typically found in aqueous film-forming foams (AFFFs). The report describes methods that can be used to identify areas of potential concern at an airport and ways to implement management and remediation practices.




Toward a PFAS-free Future


Book Description

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are extensively used in consumer products, despite their high persistence and other hazards. The risks posed by this chemical class to human health and the environment, which are increasingly becoming understood, have triggered regulation and policy changes. However, safer alternatives to these technically effective materials and methods to discover and use those alternatives are still under development. Remediation of PFAS contaminated sites will not solve the growing worldwide pollution, but substitution with safer substances at the formulation and manufacturing phases will at least abate the flow of PFASs into our bodies and environment. Introducing safer alternatives to some of the PFASs of concern used in select industry sectors, this book informs the reader about the processes of chemical hazard and alternatives assessment that can foster innovation. It is a valuable resource for both green chemists and industrial chemists interested in how they can make their products safer without compromising on function.




Forever Chemicals


Book Description

Forever Chemicals: Environmental, Economic, and Social Equity Concerns with PFAS in the Environment provides the reader with an understanding of the complex and interwoven issues associated with per- and polyfluorinated substances (PFAS) in our environment. The chapters provide in-depth perspective into various issues, including health, regulation, detection, clean-up strategies and technologies, and more. Taken together or as the reader’s interests lead them, the variety of topics covered in the book present a balanced perspective on this complex topic. It will address the current state of PFAS and where indicators are pointing for future developments. The book is also a deeper investigation of the regulatory challenges, analytical hurdles, and toxicological progress to date for the suite of PFAS chemicals. Features Explains the trends that will affect future policy and regulatory decisions Looks holistically at 4000+ PFAS chemicals Includes PFAS risk assessments at contaminated sites and biomonitoring insights Provides in-depth discussions on remediation technologies Illustrates quality and diversified content Provides a balanced perspective on this complex topic




Blood


Book Description

Get empowering, period-positive, no-nonsense facts about the science, medicine, and myths surrounding menstruation from Dr. Jen Gunter, New York Times bestselling author of The Vagina Bible! "The world's most famous and outspoken gynecologist" (The Guardian) fights myths and fearmongering with real science, inclusive facts, and shame-free advice on the topic that impacts more than 72 million Americans every month: menstruation. Most women, transgender, and non-binary people who menstruate can expect to have hundreds of periods in a lifetime. So why is real information so hard to find? Despite its significance, most education about menstruation focuses either on increasing the chances of pregnancy or preventing it. And while both are important for many people, those who menstruate deserve to know more about their bodies than just what happens in service to reproduction. At a time when charlatans, politicians, and social media are succeeding in propagating damaging misinformation with real and devastating consequences, Dr. Jen provides the antidote with science, myth busting, and no-nonsense facts. Not knowing how your body works makes it challenging to advocate for yourself. Consequently, many suffer in silence thinking their bodies are uniquely broken, or they turn to disreputable sources. Blood is a practical, empowering guide to what's typical, what's concerning, and when to seek care--recounted with expertise and frank, fearless wit that have made Dr. Jen today's most trusted voice in gynecology. Dr. Jen answers all your period-related questions, including: What exactly happens during menstruation? How heavy is too heavy? How much should periods hurt? and provides essential information about topics such as: * Why do we menstruate? * The endometrium's (the uterine lining's) fascinating connection to the immune system * The impact of stress, vaccines, and health on the menstrual cycle * Menstrual migraines, PMS, and period diarrhea (yes, it's a thing, unfortunately) * Polycystic Ovarian Syndrome (PCOS) *Fibroids and other causes of heavy bleeding * Endometriosis and the latest treatments *Legitimate menstrual products, and the facts behind toxic shock syndrome Blood is about much more than biology. It's an all-in-one, revolutionary guide that will change the way we think about, talk about--and don't talk about--our bodies and our well-being.




Yen & Jaffe's Reproductive Endocrinology - E-Book


Book Description

For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list.




The cost of inaction


Book Description

PFAS (per and polyfluoroalkylsubstances) are known to be extremely difficult to degrade in the environment and to be bioaccumulative and toxic. Exposure to PFAS is suspected to increase the risk of adverse health effects, such as impacts on the thyroid gland, the liver, fat metabolism and the immune system. This study estimates the socioeconomic costs that may result from impacts on human health and the environment from the use of PFAS. Better awareness of the costs and problems associated with PFAS exposure will assist decision-makers and the general public to make more efficient and timely risk management decisions. Findings indicate that the costs are substantial, with annual health-related costs estimated to 2.8 – 4.6 billion EUR for the Nordic countries and 52 – 84 billion EUR for all EEA countries. Overall non-health costs are estimated at 46 million – 11 billion EUR for the Nordic countries.Upon request the excel spreadsheets used for the monetarisation and valuation in this report can also be provided along with a guidance on how to use the estimation of costs for value transfer. Please contact any of the consultants or members of the steering group from the Swedish Chemicals Agency or the Danish Environmental Protection Agency if you are interested in receiving these excel spreadsheets.