Pulmonary Gas Exchange


Book Description

The lung receives the entire cardiac output from the right heart and must load oxygen onto and unload carbon dioxide from perfusing blood in the correct amounts to meet the metabolic needs of the body. It does so through the process of passive diffusion. Effective diffusion is accomplished by intricate parallel structures of airways and blood vessels designed to bring ventilation and perfusion together in an appropriate ratio in the same place and at the same time. Gas exchange is determined by the ventilation-perfusion ratio in each of the gas exchange units of the lung. In the normal lung ventilation and perfusion are well matched, and the ventilation-perfusion ratio is remarkably uniform among lung units, such that the partial pressure of oxygen in the blood leaving the pulmonary capillaries is less than 10 Torr lower than that in the alveolar space. In disease, the disruption to ventilation-perfusion matching and to diffusional transport may result in inefficient gas exchange and arterial hypoxemia. This volume covers the basics of pulmonary gas exchange, providing a central understanding of the processes involved, the interactions between the components upon which gas exchange depends, and basic equations of the process.




Basic Physiology for Anaesthetists


Book Description

Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.







Current Catalog


Book Description

First multi-year cumulation covers six years: 1965-70.




Lung, Pleura, and Mediastinum


Book Description




The Oxford Handbook of Evolutionary Medicine


Book Description

Medicine is grounded in the natural sciences, where biology stands out with regard to our understanding of human physiology and the conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, the macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system. Moreover, many adaptations to past ecologies have actually turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. One could add depression, anxiety, and other psychiatric conditions to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of up-to-date insights into the evolutionary history of ourselves as a species, exploring how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine is valuable reading for students as well as scholars in the fields of medicine, biology, anthropology and psychology.




Respiratory Muscle Training


Book Description

Respiratory Muscle Training: theory and practice is the world's first book to provide an "everything-you-need-to-know" guide to respiratory muscle training (RMT). Authored by an internationally-acclaimed expert, it is an evidence-based resource, built upon current scientific knowledge, as well as experience at the cutting-edge of respiratory training in a wide range of settings. The aim of the book is to give readers: 1) an introduction to respiratory physiology and exercise physiology, as well as training theory; 2) an understanding of how disease affects the respiratory muscles and the mechanics of breathing; 3) an insight into the disease-specific, evidence-based benefits of RMT; 4) advice on the application of RMT as a standalone treatment, and as part of a rehabilitation programme; and finally, 5) guidance on the application of functional training techniques to RMT. The book is divided into two parts – theory and practice. Part I provides readers with access to the theoretical building blocks that support practice. It explores the evidence base for RMT as well as the different methods of training respiratory muscles and their respective efficacy. Part II guides the reader through the practical implementation of the most widely validated form of RMT, namely inspiratory muscle resistance training. Finally, over 150 "Functional" RMT exercises are described, which incorporate a stability and/or postural challenge – and address specific movements that provoke dyspnoea. Respiratory Muscle Training: theory and practice is supported by a dedicated website (www.physiobreathe.com), which provides access to the latest information on RMT, as well as video clips of all exercises described in the book. Purchasers will also receive a three-month free trial of the Physiotec software platform (via www.physiotec.ca), which allows clinicians to create bespoke training programmes (including video clips) that can be printed or emailed to patients. - Introductory overviews of respiratory and exercise physiology, as well as training theory - Comprehensive, up-to-date review of respiratory muscle function, breathing mechanics and RMT - Analysis of the interaction between disease and respiratory mechanics, as well as their independent and combined influence upon exercise tolerance - Analysis of the rationale and application of RMT to over 20 clinical conditions, e.g., COPD, heart failure, obesity, mechanical ventilation - Evidence-based guidance on the implementation of inspiratory muscle resistance training - Over 150 functional exercises that incorporate a breathing challenge - www.physiobreathe.com - access up-to-date information, video clips of exercises and a three-month free trial of Physiotec's RMT exercise module (via www.physiotec.ca)




The Respiratory System


Book Description

This is an integrated textbook on the respiratory system, covering the anatomy, physiology and biochemistry of the system, all presented in a clinically relevant context appropriate for the first two years of the medical student course. - One of the seven volumes in the Systems of the Body series. - Concise text covers the core anatomy, physiology and biochemistry in an integrated manner as required by system- and problem-based medical courses. - The basic science is presented in the clinical context in a way appropriate for the early part of the medical course. - There is a linked website providing self-assessment material ideal for examination preparation.




Essentials of Mechanical Ventilation, Third Edition


Book Description

A practical application-based guide to adult mechanical ventilation This trusted guide is written from the perspective of authors who have more than seventy-five years' experience as clinicians, educators, researchers, and authors. Featuring chapters that are concise, focused, and practical, this book is unique. Unlike other references on the topic, this resource is about mechanical ventilation rather than mechanical ventilators. It is written to provide a solid understanding of the general principles and essential foundational knowledge of mechanical ventilation as required by respiratory therapists and critical care physicians. To make it clinically relevant, Essentials of Mechanical Ventilation includes disease-specific chapters related to mechanical ventilation in these conditions. Essentials of Mechanical Ventilation is divided into four parts: Part One, Principles of Mechanical Ventilation describes basic principles of mechanical ventilation and then continues with issues such as indications for mechanical ventilation, appropriate physiologic goals, and ventilator liberation. Part Two, Ventilator Management, gives practical advice for ventilating patients with a variety of diseases. Part Three, Monitoring During Mechanical Ventilation, discusses blood gases, hemodynamics, mechanics, and waveforms. Part Four, Topics in Mechanical Ventilation, covers issues such as airway management, aerosol delivery, and extracorporeal life support. Essentials of Mechanical Ventilation is a true “must read” for all clinicians caring for mechanically ventilated patients.