Juvenile Onset Huntington's Disease


Book Description

The Special Issue “Juvenile Onset Huntington’s Disease” highlights the growing interest in understanding the unique aspects of this ultra-rare disorder. After decades of research, gene therapy trials are underway for Adult Onset Huntington’s Disease (AOHD). However, patients with Juvenile Onset Huntington’s Disease (JOHD) are often excluded from these efforts, leaving many questions regarding its phenomenology. The current issue includes seven articles spanning work on the difficult emotional experiences of parents of children with JOHD; a review of the clinical manifestations of JOHD; behavioral issues in JOHD; CAG repeat and age of motor onset; autonomic nervous system dysfunction; and abnormality in MRI metabolic markers. Finally, a review of the therapeutic advances is included, highlighting future possibilities of clinical trials in JOHD subjects. The HD community—patients, family members at-risk for HD, caregivers, health-care professionals and scientists—is keen on expanding our understanding of JOHD. In the flurry of research on AOHD, those with JOHD were seemingly ‘left behind.’ The study of patients who are afflicted early in life with HD has become imperative, with this Special Issue representing just the beginning of the required effort to address this urgent need.




Heart Rate Variability (HRV) Signal Analysis


Book Description

Open a Window into the Autonomic Nervous SystemQuantifying the amount of autonomic nervous system activity in an individual patient can be extremely important, because it provides a gauge of disease severity in a large number of diseases. Heart rate variability (HRV) calculated from both short-term and longer-term electrocardiograms is an ideal win




The Role of Physical Fitness on Cardiovascular Responses to Stress


Book Description

Cardiovascular responses to physical and/ or mental stressors has been a topic of great interest for some time. For example, significant changes of cardiovascular control and reactivity have been highlighted as important mechanisms for the protective effect of exercise as a simple and effective, non medical therapy for many pathologies. However, despite the great number of studies performed to date (e.g. >54,000 entries in Pubmed for “cardiovascular stress”), important questions of the role stress has on cardiovascular function still remain. For instance, What factors account for the different cardiovascular responses between mental and physical stressors? How do these different components of the cardiovascular system interact during stress? Which cardiovascular responses to stress are the most important for identifying normal, depressed, and enhanced cardiovascular function? Can these stress-induced responses assist with patient diagnosis and prognosis? What impact does physical fitness have on the relationship between cardiovascular function and health? The current topic examined our current understanding of cardiovascular responses to stress and the significant role that physical fitness has on these responses for improved function and health. Manuscripts focusing on heart rate variability (HRV), heart rate recovery, and other novel cardiovascular assessments were especially encouraged.







Comprehensive Electrocardiology


Book Description

New edition of the classic complete reference book for cardiologists and trainee cardiologists on the theory and practice of electrocardiography, one of the key modalities used for evaluating cardiology patients and deciding on appropriate management strategies.




The Oxford Handbook of Parenting and Moral Development


Book Description

The Oxford Handbook of Parenting and Moral Development provides a collection of state-of-the-art theories and research on the role that parents play in moral development. Contributors who are leaders in their fields take a comprehensive, yet nuanced approach to considering the complex links between parenting and moral development. The volume begins by providing an overview of traditional and contemporary perspectives on parenting and moral development, including perspectives related to parenting styles, domain theory, attachment theory, and evolutionary theory. In addition, there are several chapters that explore the genetic and biological influences related to parenting and moral development. The second section of the volume explores cultural and religious approaches to parenting and moral development and contributes examples of contemporary research with diverse populations such as Muslim cultures and US Latino/as. The last major section of the volume examines recent developments and approaches to parenting, including chapters on topics such as helicopter parenting, proactive parenting, parent-child conversations and disclosure, parental discipline, and other parenting practices designed to inhibit children's antisocial and aggressive behaviors. The volume draws together the most important work in the field; it is essential reading for anyone interested in parenting and moral development.




The Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication, and Self-regulation (Norton Series on Interpersonal Neurobiology)


Book Description

A collection of groundbreaking research by a leading figure in neuroscience. This book compiles, for the first time, Stephen W. Porges’s decades of research. A leading expert in developmental psychophysiology and developmental behavioral neuroscience, Porges is the mind behind the groundbreaking Polyvagal Theory, which has startling implications for the treatment of anxiety, depression, trauma, and autism. Adopted by clinicians around the world, the Polyvagal Theory has provided exciting new insights into the way our autonomic nervous system unconsciously mediates social engagement, trust, and intimacy.




Treatment of Functional Seizures in Children and Adolescents


Book Description

In this treatment manual for functional seizures in children, adolescents, and young adults — ‘young people’ — we present the program developed by the mind-body team at The Children’s Hospital at Westmead, a tertiary care paediatric hospital located in New South Wales, Australia. The team’s Mind-Body Program, organised as part of a consultation-liaison psychiatry service within the Department of Psychological Medicine, works with young people, up to the age of 18 years, who present with functional somatic symptoms, including functional seizures. This manual describes the treatment interventions we have developed over the last 20 years through clinical trial and error, by translating research findings into our clinical practice, and by evaluating our own treatment interventions through prospective cohort studies.