Heterocycles in Life and Society


Book Description

Heterocycles in Life and Society is an introduction to the chemistry of heterocyclic compounds, focusing on their origin and occurrence in nature, biochemical significance and wide range of applications. Written in a readable and accessible style, the book takes a multidisciplinary approach to this extremely important area of organic chemistry. Topics covered include an introduction to the structure and properties of heterocycles; the key role of heterocycles in important life processes such as the transfer of hereditary information, how enzymes function, the storage and transport of bioenergy, and photosynthesis; applications of heterocycles in medicine, agriculture and industry; heterocycles in supramolecular chemistry; the origin of heterocycles on primordial Earth; and how heterocycles can help us solve 21st century challenges. For this second edition, Heterocycles in Life and Society has been completely revised and expanded, drawing on a decade of innovation in heterocyclic chemistry. The new edition includes discussions of the role of heterocycles in nanochemistry, green chemistry, combinatorial chemistry, molecular devices and sensors, and supramolecular chemistry. Impressive achievements include the creation of various molecular devices, the recording and storage of information, the preparation of new organic conductors, and new effective drugs and pesticides with heterocyclic structures. Much new light has been thrown on various life processes, while the chemistry of heterocycles has expanded to include new types of heterocyclic structures and reactions, and the use of heterocyclic molecules as ionic liquids and proton sponges. Heterocycles in Life and Society is an essential guide to this important field for students and researchers in chemistry, biochemistry, and drug discovery, and scientists at all levels wishing to expand their scientific horizon.




Handbook of Heterocyclic Chemistry


Book Description

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.




Heterocycles in Life and Society


Book Description

Contiene: Molecular to Rings Studded With Jewels; Why Nature Orefers Heterocycles; Heterocycles and Hereditary Information; Enzymes, Coenzymes and Vitamins; Heterocycles and Bioenergetics; Heterocycles and Photosynthesis; Heterocycles and Health; Heterocycles in Agriculture; Heterocycles in Industry and Technology; Modern Trends and Prospects of Development; The Origin of Heterocycles; Conclusion.




Green Synthetic Approaches for Biologically Relevant Heterocycles


Book Description

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume Two explores green catalytic systems and solvents and the techniques surrounding this approach, including metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. - Provides fully updated coverage of the field with an emphasis on sustainability - Highlights a range of different eco-friendly solvents and environmentally-friendly catalysts - Collates the experience of a global team of expert contributors




Introduction to Heterocyclic Chemistry


Book Description

A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.




Heterocyclic Chemistry


Book Description

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.




Fluorinated Heterocyclic Compounds


Book Description

A thorough survey of synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles Merging organic, heterocyclic, and fluoroorganic chemistry, fluorinated heterocyclic compounds have distinctively desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. Offering a needed overview of this relatively new addition to the heterocyclic family, this essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis, and applications of fluorinated heterocycles with chapters on: Three-, four-, five-, six-, and seven-membered fluorine-containing heterocycles Fluorinated nucleosides Fluorointermediates Applications of fluorinated heterocycles in agricultural products Pharmaceuticals containing fluorinated heterocycles Technical applications of fluorinated heterocycles Written by a team of world-recognized experts in the area of organic and industrial chemistry of fluorine, Fluorinated Heterocyclic Compounds: Synthesis, Chemistry, and Applications will prove valuable to both students and researchers from academia and industry seeking further knowledge of the synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles.




Modern Heterocyclic Chemistry, 4 Volumes


Book Description

Since vitamins, hormones, antibiotics, pharmaceuticals, dyes and many other products all contain heterocycles, they play an important role in our everyday life. The must-have reference in the field of heterocyclic compounds, comprehensively covering their synthesis, structure and chemical and physical properties in four volumes. It presents a wealth of information but stays userfriendly by focussing on the important facts. An up-to-date source of high-quality information for all organic and medicinal chemists working in this field in industry and academia.




Green Synthetic Approaches for Biologically Relevant Heterocycles


Book Description

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability




Fundamentals of Heterocyclic Chemistry


Book Description

Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters