Epigenetics of Aging


Book Description

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.







Body Composition and Physical Performance


Book Description

This book surveys the entire field of body composition as it relates to performance. It includes a clear definition of terminology and a discussion of the various methods for measuring body composition. The authored papers represent a state-of-the-art review of this controversial field and address questions such as: What is a better measure of body compositionâ€"body fat or lean body mass? Does being overweight for one's height really affect performance? The book also addresses the issue of physical appearance as it relates to body fatness and performance. It includes an in-depth discussion of many of the topics of interest to those involved in sports medicine and exercise physiology.




Singing For Dummies


Book Description

Go from singing in the shower to taking your audience’s breath away Whether you picture yourself as the next Ariana Grande or just feel like picking up a new hobby, Singing For Dummies walks you through the surprisingly straightforward steps you’ll need to take to develop your voice. It’s a practical guide to every important aspect of singing, from vocal techniques to performance tips. You’ll learn exercises and practice songs that gradually improve your craft and receive instruction on the latest technology and recording devices to capture and play back your songs. Singing For Dummies also shows you how to: Understand and use important singing techniques, improve your tone, upgrade your posture, and maximize your breath Maintain your voice with preventative self-care that keeps your vocal cords in tiptop shape Sing with instrumental accompaniment or with a partner in a duet Perfect for men, women, boys, and girls, Singing For Dummies is the most intuitive and accessible resource on the market for anyone who hopes to find their voice.




Child Development From Infancy to Adolescence


Book Description

Winner of the 2020 Textbook Excellence Award from the Textbook & Academic Authors Association (TAA) Chronologically organized, Child Development From Infancy to Adolescence, Second Edition presents topics within the field of child development through unique and highly engaging Active Learning opportunities. The Active Learning features foster a dynamic and personal learning process for students. Within each chapter, authors Laura E. Levine and Joyce Munsch introduce students to a wide range of real-world applications of psychological research to child development. Pedagogical features help students discover the excitement of studying child development and equip them with skills they can use long after completing the course. Digital Option / Courseware SAGE Vantage is an intuitive digital platform that delivers this text’s content and course materials in a learning experience that offers auto-graded assignments and interactive multimedia tools, all carefully designed to ignite student engagement and drive critical thinking. Built with you and your students in mind, it offers simple course set-up and enables students to better prepare for class. Assignable Video with Assessment Assignable video (available with SAGE Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. LMS Cartridge (formerly known as SAGE Coursepacks): Import this title’s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Also of Interest: Case Studies in Lifespan Development by Stephanie M. Wright presents a series of 12 case studies shaped by the contributions of real students to build immersive examples that readers can relate to and enjoy. Bundle Case Studies in Lifespan Development with Child Development From Infancy To Adolescence, Second Edition for even more savings!




The Sage Age


Book Description

Combining the knowledge of physics with intuitive practice is no small task. The two disciplines often use the same words to mean entirely different things. Written for the seeker with more than a casual interest, The Sage Age - Blending Science with Intuitive Wisdom demystifies complex ideas with intelligent analogies and examples designed to appeal to both the scientist and the natural intuitive. Four years in the writing, this expansive new work combines knowledge from the physical sciences and the intuitive arts to present a visionary perspective that harmonizes these diverse disciplines into one body of knowledge. With a well-researched approach to its subjects, The Sage Age covers a broad range of material from ancient to modern thought, frontier science and current intuitive practice to deliver a depth and breadth of understanding that culminates in a holistic perspective for our time. Living up to its mantra of "new models for new thought," The Sage Age is certain to be a catalyst for dialogue and is destined to be a major work in its field.




Weight Management


Book Description

The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.




Fitness Measures and Health Outcomes in Youth


Book Description

Physical fitness affects our ability to function and be active. At poor levels, it is associated with such health outcomes as diabetes and cardiovascular disease. Physical fitness testing in American youth was established on a large scale in the 1950s with an early focus on performance-related fitness that gradually gave way to an emphasis on health-related fitness. Using appropriately selected measures to collected fitness data in youth will advance our understanding of how fitness among youth translates into better health. In Fitness Measures and Health Outcomes in Youth, the IOM assesses the relationship between youth fitness test items and health outcomes, recommends the best fitness test items, provides guidance for interpreting fitness scores, and provides an agenda for needed research. The report concludes that selected cardiorespiratory endurance, musculoskeletal fitness, and body composition measures should be in fitness surveys and in schools. Collecting fitness data nationally and in schools helps with setting and achieving fitness goals and priorities for public health at an individual and national level.




Aging of the Genome


Book Description

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.