Hunting Down Huntington's


Book Description

My book is targeted towards any individual who has been affected by Huntington Disease, professionals and families, patients and their caregivers. The key theme is the devastation caused by this rare and fatal diabolical disease, it describes the wider circle affected when this disease strikes and how various persons handle the news. Hunting down Huntington's also presents strategies that are beneficial in navigating through this disease process. The book aims to increase the awareness of this disorder and inform the reader of its origins, history and on going research. I would like the reader to take away. . new knowledge of the HD process . learn about the ongoing research . become involved in the larger HD community chapters . learn ways where they can contribute . have a greater awareness of this condition My book's objective is to raise awareness for this illness and to encourage people to become involved in the local chapters. My desire is to give hope and encouragement to affected families. I'm also directing all royalties from the book to THE HUNTINGTON'S SOCIETY OF CANADA. Reading and learning about neurological diseases is significant because it's already believed that if a cure is found for HD other neurological dementias could also be prevented. My book isn't a supplement for business or a course.




Food for Huntington's Disease


Book Description

Food and Huntington's Disease is another book in a series of books related to the benefits of food on brain function. This book designates the possible beneficial effects of edible natural products and their active materials on Huntington's disease. This is a progressive neurodegenerative disease that could cause uncontrolled movements, cognitive difficulties and emotional disturbances. The aim of this book and its series is to create awareness in general audiences about the dietary perception to reduce the occurrence of Huntington's disease. This may enable a better understanding and possibly reduce the cost on medical bills for patients (approximately $4500/year/person) and the insurance companies. Literature revealed that this disturbing neurodegenerative disorder has a higher prevalence in Europe (3-7 in 100,000), North America (4-5 in 100,000), and Australia than in Asian countries. Studies suggest that mutation in the HD gene and the repeat expansion play an important role in the pathophysiology of this disease. The genetic defect underlying Huntington's disease is unstable, caused by an abnormal CAG expansion within the first exon of the Huntingtin gene (HTT), leading to an expanded polyglutamine (polyQ) track in the HTT protein. This disease is an inherited one. Even though the prevalence rate is moderate, scientists predict that a lot of people possess the possibility of carrying this disease. Mitochondrial dysfunction and oxidative stress could very highly play a role in this disease. In the last decade, the benefits of food on many diseases - including brain diseases - were explored. This book aims to summarize the recent updates on the benefit of natural edible materials and their active principles on the prevention or delaying of the progression or the management of this disease. The editors feel highly obligated to all the contributors for this initiative. Undeniably, they believe that the information provided in this book would raise the awareness of the readers and could possibly help them to understand the disease process and the benefits of food items on Huntington's' disease management.




The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy


Book Description

This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.




Genetic Twists of Fate


Book Description

How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.




Devious Lies


Book Description

"A sizzling, chemistry-filled enemies-to-lovers romance, which is both crackaliciously addictive and angst-central. I couldn't get enough of Nash and Em. One of my favorite books of the year." - L.J. Shen, USA Today Bestselling AuthorFrom USA Today bestselling author Parker S. Huntington comes an enemies-to-lovers, slow-burn romance full of revenge and a dash of fate."She could enjoy her pretty, perfect world a little longer. Soon enough, everything she owned would be mine."I had a plan to escape the friend zone.Step one: sneak into Reed's room.Step two: sleep with him.But when the lights turned on, it wasn't familiar blue eyes I saw.These were dark, angry, and full of demons.And they belonged to Reed's much older brother.Four years later, Nash Prescott is no longer the help's angry son.I'm no longer the town's prized princess.At twenty-two, I'm broke, in need of a job.At thirty-two, he's a billionaire, in need of revenge.Who cares if my family ruined his?Who cares if he looks at me with pure loathing?Who cares if every task he assigns me is designed to torture?I need the money.Simple as that.I'll suffer his cruelty in silence, knowing there's one thing he wants more than revenge?Me.




Gene Hunter


Book Description

Describes the life and career of Nancy Wexler, neuropsychologist, whose work focuses on the genes responsible for Huntington's disease.




Shadows on the Koyukuk


Book Description

“I owe Alaska. It gave me everything I have.” Says Sidney Huntington, son of an Athapaskan mother and white trader/trapper father. Growing up on the Koyukuk River in Alaska’s harsh Interior, that “everything” spans 78 years of tragedies and adventures. When his mother died suddenly, 5-year-old Huntington protected and cared for his younger brother and sister during two weeks of isolation. Later, as a teenager, he plied the wilderness traplines with his father, nearly freezing to death several times. One spring, he watched an ice-filled breakup flood sweep his family’s cabin and belongings away. These and many other episodes are the compelling background for the story of a man who learned the lessons of a land and culture, lessons that enabled him to prosper as trapper, boat builder, and fisherman. This is more than one man's incredible tale of hardship and success in Alaska. It is also a tribute to the Athapaskan traditions and spiritual beliefs that enabled him and his ancestors to survive. His story, simply told, is a testament to the durability of Alaska's wild lands and to the strength of the people who inhabit them.




The Third Wave


Book Description

Between 1974 and 1990 more than thirty countries in southern Europe, Latin America, East Asia, and Eastern Europe shifted from authoritarian to democratic systems of government. This global democratic revolution is probably the most important political trend in the late twentieth century. In The Third Wave, Samuel P. Huntington analyzes the causes and nature of these democratic transitions, evaluates the prospects for stability of the new democracies, and explores the possibility of more countries becoming democratic. The recent transitions, he argues, are the third major wave of democratization in the modem world. Each of the two previous waves was followed by a reverse wave in which some countries shifted back to authoritarian government. Using concrete examples, empirical evidence, and insightful analysis, Huntington provides neither a theory nor a history of the third wave, but an explanation of why and how it occurred. Factors responsible for the democratic trend include the legitimacy dilemmas of authoritarian regimes; economic and social development; the changed role of the Catholic Church; the impact of the United States, the European Community, and the Soviet Union; and the "snowballing" phenomenon: change in one country stimulating change in others. Five key elite groups within and outside the nondemocratic regime played roles in shaping the various ways democratization occurred. Compromise was key to all democratizations, and elections and nonviolent tactics also were central. New democracies must deal with the "torturer problem" and the "praetorian problem" and attempt to develop democratic values and processes. Disillusionment with democracy, Huntington argues, is necessary to consolidating democracy. He concludes the book with an analysis of the political, economic, and cultural factors that will decide whether or not the third wave continues. Several "Guidelines for Democratizers" offer specific, practical suggestions for initiating and carrying out reform. Huntington's emphasis on practical application makes this book a valuable tool for anyone engaged in the democratization process. At this volatile time in history, Huntington's assessment of the processes of democratization is indispensable to understanding the future of democracy in the world.




Hyperkinetic Movement Disorders


Book Description

Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evidence so you can apply it into your practice. The judicious use of diagnostic criteria algorithms rating scales management guidelines Provides a robust framework for clear patient management. Throughout the text, QR codes* provide smartphone access to case-study videos of hyperkinetic symptoms. Purchase includes an enhanced Wiley Desktop Edition.* This is an interactive digital version featuring: all text and images in fully searchable form integrated videos of presentations View a sample video: www.wiley.com/go/albanese highlighting and note taking facilities book marking linking to additional references Hyperkinetic Movement Disorders provides you with the essential visual and practical tools you need to effectively diagnose and treat your patients. *Full instructions for using QR codes and for downloading your digital Wiley DeskTop Edition are inside the book.




Faces of Huntington's


Book Description