Radiology of Haemophilic Arthropathies


Book Description

The use of potent coagulation factor concentrates has dramatically changed the clinical picture and the life expectancy of haemophiliacs. The aim of well-organized care of haemophiliacs is to prevent not only life-threatening bleeding episodes, but also the development of disabling arthropathies. In spite of numerous effective drugs and the beneficial effect of early synovectomy, haemophilic arthropathy will long remain a crux of everyday practice. Based on 10 years' experience at the National Institute of Haematology and Blood Transfusion, this volume presents a detailed description of the X-ray morphology of haemophilic arthropathy. The rich series of illustrations should serve for guidance in diagnostics and differential diagnostics, and will provide help in establishing the stage and in estimating the prognosis. It will be of interest to all physicians engaged in the care of haemophiliacs. Susan R. Hollan, M. D. Corresponding Member of the Hungarian Academy of Sciences, Professor of Haematology. Director of the National Institute of Haematology and Blood Transfusion 9 Acknowledgements I gratefully acknowledge the help of all those who have contributed to this mono graph. First I wish to acknowledge the help of Professor Susan Hollan, Corre sponding Member of the Hungarian Academy of Sciences, Director of the National Institute of Haematology and Blood Transfusion, Professor of Haematology at the Postgraduate Medical School, Editor-in-chief of Haemat%gia, an internation al quarterly, who provided us with the most modern equipment and has been interested in, and encouraged, our work throughout.




Diagnostic Imaging in Hemophilia


Book Description

During recent decades there has been a revolutionary change in the life expectancy and quality of life of the hemophiliac. This has been achieved by hematologic and c1inical research, and the future for the hemophiliac depends upon further medical knowledge and research. In spite of the dramatically improved life situation of hemophiliacs, hemorrhagic complications remain a threat. The hemorrhagic disorder may influence and/or aggravate the course of trauma or other diseases in these patients. Hemophiliacs suffering from hemorrhagic complications or eligible for elective surgery should be referred to Hemophilia Treatment and Training Centers, where evaluation and examination are performed by a multidisciplinary team with experience and interest in the disease. The radio10gist is an important member ofthis team. In the past diagnostic imaging has been based mainly on conventional radiography, and this is still very important for the diagnosis ofhemophilic complications, but the diagnostic imaging of today offers a wide range of modalities-conventional radiography, computed tomography, sonography, radionuc1ide imaging, and, in its infancy, magnetic resonance imaging. Thus there is a need for a thorough description of the potential and limitations ofthese modern diagnostic techniques.




The Management of the Haemophilc Arthropathy


Book Description

Frontiers in Arthritis is an ebook series devoted to publishing the latest advances in arthritis medicine and research. Each volume brings forth contributions on topics relevant to the diagnosis, management and treatment of arthritis. The ebook series is essential reading for rheumatologists and orthopedic surgeons involved in clinical research and practice. This volume presents comprehensive information about the pathology, diagnosis and treatment of haemophilic arthropathy. Readers will find information about knee, hip, elbow, foot and ankle surgery in patients affected by haemophilia as well as special topics (microsurgery and postoperative rehabilitation and health risks). The broad range of information presented in this volume makes it the definitive handbook on arthritis in haemophiliac cases and the management of related complications.







The Haemophilic Joints


Book Description

Edited by an orthopaedic surgeon who is a leading specialist in the treatment of the musculo-skeletal complications of haemophilia.The Haemophilic Joints: New Perspectives reviews the different protocols for the orthopaedic management of the haemophilic articulations. The book draws together, in a single volume, the more recent perspectives of all the orthopaedic methods that can be applied in the diagnosis and treatment of the haemophilic joints from numerous specialists worldwide. It will be an invaluable resource for all those treating the articular problems in people with haemophilia.







Understanding Early Hemophilic Arthropathy in Children and Adolescents Through Magnetic Resonance Imaging Based on T2 Mapping


Book Description

Hemophilia is an X-linked recessive disease, which mainly affects males. This disease results in bleeding events targeting mainly the joints, which leads to arthropathy and cartilage degeneration. Human cartilage is primarily composed of water; as a result, past studies have noted that magnetic resonance imaging through T2 mapping can hold great promise for assessment of early changes in the cartilage. Hence this cross-sectional study seeks to validate T2 mapping as a tool for studying children and adolescents with hemophilic arthropathy. T2 relaxation times of hemophilia and healthy ankle/knee joints were compared, and found to have significant differences in mean T2 relaxation times. Furthermore, significant negative associations between age and T2 relaxation times were noted in both groups. Therefore, this investigation suggests that future studies may be able to use T2 mapping as a tool to better understand early hemophilic arthropathy in children and adolescents.




Joint Surgery in the Adult Patient with Hemophilia


Book Description

This book provides clear instruction on the surgical treatment of joint problems in adult hemophilia patients. The procedures applicable to specific joints, including the shoulder, elbow, hip, knee and ankle, are carefully reviewed with the aid of high-quality illustrations. The surgical treatment of articular hemophilic pseudotumors and bone cysts is also considered. In addition, clinically relevant information is provided on a range of topics, such as the treatment of hemophilic hemarthrosis, the imaging of hemophilic joints, hematological perioperative management, anesthesia, rehabilitation and pharmacoeconomics. Finally, the controversial issues of postoperative thromboembolic prophylaxis and the role of COX-2 inhibitors in hemophiliacs are reviewed. The guidance provided draws on both the authors’ extensive personal experience and an in-depth review of the pertinent literature. The book offers an excellent, up-to-date account of knowledge on musculoskeletal problems and approaches to joint surgery in adults with hemophilia. It will be of value to orthopedic surgeons, rehabilitation physicians, hematologists, radiologists and pharmacy researchers.