IMMUNE BIOTECHNOLOGY


Book Description

This book covers the whole immunology and immune technology of pharmaceutical aspects; it begins with the main players of immunology and covers all components of immunology such as complement, antigens, immunoglobulin’s, antigen-antibody reactions and selected tests, cells involved In immune responses and antigen recognition. Chapter seven covers the major histocompatibility complex (MHC) and t-cell receptors - role in immune responses. Chapter eight deals with the response to antigen: Processing and presentation MHC restriction and role of the thymus. Moreover, cell-mediated immunity, cytokines and immunoregulation, immunization, MHC: genetics and role in transplantation is discussed in this section. Tolerance and autoimmunity, hypersensitivity reactions, tumor immunology and immunodeficiency is discussed in the subsequent chapters. Finally, Hybridoma technology for production of monoclonal antibodies, vaccine technology and immunological techniques is discussed in the last three chapters.This book is written as there need of text book for the students of medical and paramedical discipline such as Pharmacy, Medicine etc., and biotechnology, biomedical, Biochemical, microbiology, biochemistry from both engineering and biology backgrounds. The main features of this book are that the coverage of various Indian Universities curriculum of the aforesaid subjects and each contains illustrations to understand the subject matter.




Immunology and Animal Biotechnology


Book Description

Biotechnology as any technique that used living organisms to make or modify a product, to improve plants or animals or to develop microorganisms for specific uses. Biotechnology as any technique that used living organisms to make or modify a product, to improve plants or animals or to develop microorganisms for specific uses. Animal biotechnology in use today is based on the science of genetic engineering. Under the umbrella of genetic engineering exist other technologies, such as transgenics and cloning, that also are used in animal biotechnology. Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defence. If the immune system is not functioning as it should, it can result in disease, such as autoimmunity, allergy and cancer. Immunity is a biological term that describes a state of having sufficient biological defences to avoid infection, disease, or other unwanted biological invasion. Immunity involves both specific and non-specific components. The non-specific components act either as barriers or as eliminators of wide range of pathogens irrespective of antigenic specificity. Other components of the immune system adapt themselves to each new disease encountered and are able to generate pathogen-specific immunity. This book sums up information about Animal Biotechnology and is a valuable tool for students as well as teachers. The aim of this book is to provide the readers materials on the subject in a lucid and readable form so as to enable the research scholars, scientists, zoologist and even the common men to understand the subject properly.







Opportunities in Biotechnology for Future Army Applications


Book Description

This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.




Monoclonal Antibodies in Biotechnology


Book Description

Monoclonal antibodies are one of the most exciting developments in biotechnology in recent years; this book provides a comprehensive description of principles, methodologies and applications of this powerful technology to modern science and industry.




Lab Manual in Biochemistry, Immunology and Biotechnology


Book Description

Lab Manual is intended to be a handy reference for undergraduate and postgraduate students in life science and allied fields. The book covers fundamental exercises as well as advanced protocols, along with authentic explanation of various techniques and precautions pertaining to common errors in the laboratory. It is a complete instruction manual that imparts knowledge on principles, protocols and applications on techniques of biochemistry, immunology and biotechnology accurately in a user-friendly style.







Antibodies and Their Role in Therapeutics


Book Description

Beginning with the structure, types, functions, and gene organization of antibodies, the book aims to shine a detailed light on the monoclonal antibodies (often referred to as mAbs) that have revolutionized the fields of therapeutics and diagnostics. The book describes the different ways of generating chimeric, humanized, and fully human monoclonal antibodies, emphasizing phage display, hybridoma, and rDNA technology. In addition, the book focuses on the various recombinant antibody formats in detail: Drug conjugates: Antibody-drug conjugates (ADCs), Immunotoxins (Recombinant, Humanized and Fully Human) and Antibody-antibiotic conjugate (AAC) Bispecific antibodies: scFv based (BiTE, DARTs and TandAbs) and Full-length IgG based Abzymes and Antibody-directed enzyme prodrug therapy (ADEPT) Fc-fusion proteins Single-domain antibodies (VHH and IgNAR sdAb) The book discusses the various therapeutic applications of monoclonal antibodies, along with the immunogenicity issues. The book also covers the modes of administration and side effects of monoclonal antibodies, along with the challenges and issues faced while developing a monoclonal antibody into a therapeutic agent. Modifications introduced by the researchers to decrease the immunogenicity issues and increase the efficacy of therapeutic mAbs are also described. The book is an invaluable resource for researchers and students in biology and medicine, biotechnology, immunology, genetics, molecular biology, and anyone interested in antibody engineering.




Systems and Synthetic Immunology


Book Description

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.




A History of Modern Immunology


Book Description

A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author