Implication of Oxysterols and Phytosterols in Aging and Human Diseases


Book Description

This book provides basic knowledge of the biology, chemistry, and function of oxysterols and its derivatives as well as of phytosterols in numerous human diseases. The book is divided into six sections and begins with an introduction to the biological and chemical properties of oxysterols and its derivatives as well as phytosterols, their synthesis, and the methods currently used for their detection in various biospecimens. The following section discusses in detail the various effects of oxysterols on numerous human diseases, including infectious diseases, inflammatory and autoimmune diseases, atherosclerosis, and cancer, as well as neurological and neuropsychiatric disorders. Importantly, the potential of oxysterols as biomarkers for some of these diseases is also highlighted. The book concludes with an outlook on the pharmacological and nutritional effects of oxysterols and phytosterols and their potential use by the food, and pharmaceutical industries. Aiming to provide an in-depth overview of the biological and the chemical properties of oxysterols and phytosterols and their implications for human health, this book will be of interest to basic and clinical scientists, as well as to anyone working in the food or pharmaceutical industry who is exploring the potential of oxysterols and phytosterols.




The Biology of Cholesterol and Related Steroids


Book Description

The Biology of Cholesterol and Related Steroids focuses on the study of sterols in relation to living organisms. The publication first takes a look at the analysis of sterols and related steroids and the distribution of sterols and related steroids in nature, as well as the processes of extraction and separation and presence of sterols in plants, fungi, vertebrates, and invertebrates. The text then ponders on biosynthesis of sterols and metabolism of cholesterol. Topics include formation of fatty acid esters of cholesterol, steroid hormones, biosynthetic pathway to sterols, reaction mechanisms, and comparative aspects of sterol synthesis. The manuscript examines the developmental aspects of cholesterol metabolism and sterols in biological membranes. The book also reviews cholesterol synthesis in animal tissues, sterol metabolism in isolated cells, and epidemiology of the plasma cholesterol. Discussions focus on selection of statistical populations, genetic influences, regulation of sterol synthesis, general aspects of sterol metabolism, and removal of cell cholesterol in vivo. The publication is a dependable source of data for biochemists and readers interested in the biology of cholesterol and steroids.




Whole Grains and their Bioactives


Book Description

A review of various types of whole grains, the bioactives present within them, and their health-promoting effects As rates of obesity and other chronic conditions continue to rise, so too does the need for clear and accurate information on the connections between diet and disease, particularly regarding the cereal grains that dominate the Western diet. In this volume, editors Jodee Johnson and Taylor Wallace assemble a panel of leading experts to address this issue. The result is a comprehensive examination of the cereal and pseudo-cereal grains and their most important bioactive compounds. Not only does this volume offer summaries of existing research, it also places these findings within the larger context of health promotion and disease prevention. This includes frank discussions on the limitations of existing studies, as well as current gaps in research for those who want to offer evidence-based recommendations to their patients. Topics addressed include: Methodical analyses of domesticated grain species, their horticultural history, nutritional composition, and known effects on health Beneficial properties of certain bioactive compounds found in particular grain species How bioactive compounds work within an individual’s overall diet to increase health and prevent disease Academic and industry researchers, as well as medical practitioners and public health professionals, will appreciate Whole Grains and their Bioactives, not only as an engaging overview of current research, but also as an illuminating contribution to the often-murky debate surrounding health and the human diet.







Chemical, Biological, and Functional Aspects of Food Lipids


Book Description

Based on years of academic and industrial research by an international panel of experts, Chemical, Biological, and Functional Properties of Food Lipids, Second Edition provides a concise, yet well-documented presentation of the current state of knowledge on lipids. Under the editorial guidance of globally recognized food scientists Zdzislaw E. Siko




Cholesterol and Phytosterol Oxidation Products


Book Description

This book comprehensively reviews several aspects of cholesterol oxidation products: cholesterol oxidation mechanisms, analytical determination, origin and content of these compounds in foods and biological samples, and their biological effects, with an emphasis on recent advances in these fields. Information on different aspects of phytosterol oxidation is reviewed. Little research has been conducted on the analysis of mixed sterol oxidation products. Mixed diets containing both cholesterol and phytosterols can contain a complex array of oxidation products generated from these sterols. Research into the problem of analyzing these complex mixtures of compounds is highlighted.




Chemical Abstracts


Book Description




Cholesterol


Book Description

Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs.




Endothelial Cell Dysfunctions


Book Description

Noted experts survey and evaluate the latest research in the growing field of endothelial cell involvement in the initiation and development of various diseases. Research-oriented chapters span a diversity of topics, including endothelial cell response to various injuries and its crucial role in inflammation, immunity, viral infection, hypertension, hyperlipidemia, atherosclerosis, diabetes mellitus, neoplasia, and metastasis.




Fungal Lipid Biochemistry


Book Description

Fungal Lipid Biochemistry explores the intricate biochemistry of fungal and microbial lipids. The book focuses on recent advances in our knowledge about the distribution, classification, and biochemistry of fungal lipids. The book is divided into four sections, starting with an introduction to fungal lipids which includes definition, classification, nomenclature, and some historical aspects of fungal lipid research. This is followed by an overview of fungal lipids, and environmental and nutritional cultural conditions affecting lipid production. The second section contains four chapters that explain the metabolism of fatty acids, their biosynthetic pathways together with their storage mainly in the form of triacylglycerols. The latter includes a key description of the recently discovered lipid droplet acting as a highly specific cellular compartment for the storage of neutral lipids. The third section contains five chapters concerned with the relatively recent interpretation of other major lipid classes which include glycerophospholipids, sphingolipids, aliphatic hydrocarbons, sterols, carotenoids, and polyprenols and their occurrence and biosynthesis. The final section covers lipid metabolism during fungal development and sporulation. Key features - Extensive coverage of fungal lipid biochemistry, with a focus on recent knowledge - Includes chapters for specific lipid classes with notes on their metabolism - Gives knowledge about the role of lipids in fungal growth and development - Provides references for further reading This book is a comprehensive reference for academics, scientific researchers, and industrial scientists (in biotechnology, food science and nutritional health) who require information about fungal lipid composition and biochemistry.