In Search of Mechanisms


Book Description

Neuroscientists investigate the mechanisms of spatial memory. Molecular biologists study the mechanisms of protein synthesis and the myriad mechanisms of gene regulation. Ecologists study nutrient cycling mechanisms and their devastating imbalances in estuaries such as the Chesapeake Bay. In fact, much of biology and its history involves biologists constructing, evaluating, and revising their understanding of mechanisms. With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species.




In Search of the Causes of Evolution


Book Description

Evolutionary biology has witnessed breathtaking advances in recent years. Some of its most exciting insights have come from the crossover of disciplines as varied as paleontology, molecular biology, ecology, and genetics. This book brings together many of today's pioneers in evolutionary biology to describe the latest advances and explain why a cross-disciplinary and integrated approach to research questions is so essential. Contributors discuss the origins of biological diversity, mechanisms of evolutionary change at the molecular and developmental levels, morphology and behavior, and the ecology of adaptive radiations and speciation. They highlight the mutual dependence of organisms and their environments, and reveal the different strategies today's researchers are using in the field and laboratory to explore this interdependence. Peter and Rosemary Grant--renowned for their influential work on Darwin's finches in the Galápagos--provide concise introductions to each section and identify the key questions future research needs to address. In addition to the editors, the contributors are Myra Awodey, Christopher N. Balakrishnan, Rowan D. H. Barrett, May R. Berenbaum, Paul M. Brakefield, Philip J. Currie, Scott V. Edwards, Douglas J. Emlen, Joshua B. Gross, Hopi E. Hoekstra, Richard Hudson, David Jablonski, David T. Johnston, Mathieu Joron, David Kingsley, Andrew H. Knoll, Mimi A. R. Koehl, June Y. Lee, Jonathan B. Losos, Isabel Santos Magalhaes, Albert B. Phillimore, Trevor Price, Dolph Schluter, Ole Seehausen, Clifford J. Tabin, John N. Thompson, and David B. Wake.




Evaluating Evidence of Mechanisms in Medicine


Book Description

This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.




Mechanisms in Ancient Chinese Books with Illustrations


Book Description

This book presents a unique approach for studying mechanisms and machines with drawings that were depicted unclearly in ancient Chinese books. The historical, cultural and technical backgrounds of the mechanisms are explained, and various mechanisms described and illustrated in ancient books are introduced. By utilizing the idea for the conceptual design of modern mechanisms, all feasible designs of ancient mechanisms with uncertain members and joints that meet the technical standards of the subjects’ time periods are synthesized systematically. Ancient Chinese crossbows (the original crossbow and repeating crossbows), textile mechanisms (silk-reeling mechanism, spinning mechanisms, and looms), and many other artisan's tool mechanisms are used as illustrated examples. Such an approach provides a logical method for the reconstruction designs of ancient mechanisms with uncertain structures. It also provides an innovative direction for researchers to further identify the original structures of mechanisms and machines with drawings in ancient literature. This book can be used as a textbook and/or supplemental reading material for courses related to history of ancient (Chinese) machinery and creative mechanism design for senior and graduate students.




Mechanisms of Clinical Signs - EPub3


Book Description

- Clinical Pearls highlight the main signs which students and trainees should look out for to help them identify conditions with which the patients present. - A Student Consult eBook is available with the purchase of a print book, and provides access to a total of 200 multiple choice questions covering the 7 body systems, to test students and trainees' knowledge of the content. - The eBook contains links to audio and video examples of particular signs which have to be heard or observed over a period of time in order to be identified correctly, e.g. Agonal respiration in Chapter 2 Respiratory Signs. - New images are added to depict clinical signs where no images were present in the previous edition.




A Brief Illustrated History of Machines and Mechanisms


Book Description

Machines have always gone hand-in-hand with the cultural development of m- kind throughout time. A book on the history of machines is nothing more than a specific way of bringing light to human events as a whole in order to highlight some significant milestones in the progress of knowledge by a complementary persp- tive into a general historical overview. This book is the result of common efforts and interests by several scholars, teachers, and students on subjects that are connected with the theory of machines and mechanisms. In fact, in this book there is a certain teaching aim in addition to a general historical view that is more addressed to the achievements by “homo faber” than to those by “homo sapiens”, since the proposed history survey has been developed with an engineering approach. The brevity of the text added to the fact that the authors are probably not com- tent to tackle historical studies with the necessary rigor, means the content of the book is inevitably incomplete, but it nevertheless attempts to fulfil three basic aims: First, it is hoped that this book may provide a stimulus to promote interest in the study of technical history within a mechanical engineering context. Few are the co- tries where anything significant is done in this area, which means there is a general lack of knowledge of this common cultural heritage.




Design and Analysis of Mechanisms


Book Description

A planar or two-dimensional (2D) mechanism is the combination of two or more machine elements that are designed to convey a force or motion across parallel planes. For any mechanical engineer, young or old, an understanding of planar mechanism design is fundamental. Mechanical components and complex machines, such as engines or robots, are often designed and conceptualised in 2D before being extended into 3D. Designed to encourage a clear understanding of the nature and design of planar mechanisms, this book favours a frank and straightforward approach to teaching the basics of planar mechanism design and the theory of machines with fully worked examples throughout. Key Features: Provides simple instruction in the design and analysis of planar mechanisms, enabling the student to easily navigate the text and find the desired material Covers topics of fundamental importance to mechanical engineering, from planar mechanism kinematics, 2D linkage analyses and 2D linkage design to the fundamentals of spur gears and cam design Shows numerous example solutions using EES (Engineering Equation Solver) and MATLAB software, with appendices dedicated to explaining the use of both computer tools Follows end-of-chapter problems with clearly detailed solutions




Making Things Move DIY Mechanisms for Inventors, Hobbyists, and Artists


Book Description

Get Your Move On! In Making Things Move: DIY Mechanisms for Inventors, Hobbyists, and Artists, you'll learn how to successfully build moving mechanisms through non-technical explanations, examples, and do-it-yourself projects--from kinetic art installations to creative toys to energy-harvesting devices. Photographs, illustrations, screen shots, and images of 3D models are included for each project. This unique resource emphasizes using off-the-shelf components, readily available materials, and accessible fabrication techniques. Simple projects give you hands-on practice applying the skills covered in each chapter, and more complex projects at the end of the book incorporate topics from multiple chapters. Turn your imaginative ideas into reality with help from this practical, inventive guide. Discover how to: Find and select materials Fasten and join parts Measure force, friction, and torque Understand mechanical and electrical power, work, and energy Create and control motion Work with bearings, couplers, gears, screws, and springs Combine simple machines for work and fun Projects include: Rube Goldberg breakfast machine Mousetrap powered car DIY motor with magnet wire Motor direction and speed control Designing and fabricating spur gears Animated creations in paper An interactive rotating platform Small vertical axis wind turbine SADbot: the seasonally affected drawing robot Make Great Stuff! TAB, an imprint of McGraw-Hill Professional, is a leading publisher of DIY technology books for makers, hackers, and electronics hobbyists.




Translation Mechanisms and Control


Book Description

A subject collection from Cold Spring Harbor Perspectives in Biology.