Micro-, Meso- and Macro-Connectomics of the Brain


Book Description

This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.




Handedness and Brain Asymmetry


Book Description

Brain asymmetry for speech is moderately related to handedness but what are the rules? Are symmetries for hand and brain associated with characteristics such as intelligence, motor skill, spatial reasoning or skill at sports? In this follow up to the influential Left, Right Hand and Brain (1985) Marian Annett draws on a working lifetime of research to help provide answers to crucial questions. Central to her argument is the Right Shift Theory - her original and innovative contribution to the field that seeks to explain the relationships between left-and right-handedness and left-and right-brain specialisation. The theory proposes that handedness in humans and our non-human primate relations depends on chance but that chance is weighted towards right-handedness in most people by an agent of right-hemisphere disadvantage. It argues for the existence of a single gene for right shift (RS+) that evolved in humans to aid the growth of speech in the left hemisphere of the brain. The Right Shift Theory has possible implications for a wide range of questions about human abilities and disabilities, including verbal and non verbal intelligence, educational progress and dyslexia, spatial reasoning, sporting skills and mental illness. It continues to be at the cutting edge of research, solving problems and generating new avenues of investigation - most recently the surprising idea that a mutant RS+ gene might be involved in the causes of schizophrenia and autism. Handedness and Brain Asymmetry will make fascinating reading for students and researchers in psychology and neurology, educationalists, and anyone with a keen interest in why people have different talents and weaknesses.




Hemispheric Asymmetry


Book Description

Is "right-brain" thought essentially creative, and "left-brain" strictly logical? Joseph B. Hellige argues that this view is far too simplistic. Surveying extensive data in the field of cognitive science, he disentangles scientific facts from popular assumptions about the brain's two hemispheres. In Hemispheric Asymmetry, Hellige explains that the "right brain" and "left brain" are actually components of a much larger cognitive system encompassing cortical and subcortical structures, all of which interact to produce unity of thought and action. He further explores questions of whether hemispheric asymmetry is unique to humans, and how it might have evolved. This book is a valuable overview of hemispheric asymmetry and its evolutionary precedents.




Individual Differences in Hemispheric Specialization


Book Description

This volume originates from a NATO Advanced Research Workshop held in Maratea. Italy from 8th-15th October 198~. Aims and contributions are described at greater length in the Introduction and the following chapters. It is hoped that this volume will provide a critical overview of hemispheric specialization in relation to individual differences, but one that is not intended to be comprehensive. Three contributions on this theme are made by authors who were invited to the Workshop but were unable to participate in it. The volume contains a critical appraisal of the differentially specialized functions of left and right human cerebral hemispheres in verbal and visuospatial domains respectively (formerly cerebral dominance). in relation to individual variation due. for example. to gender and handedness. Critical cross-comparison of several methods of assessing hemispheric specialization such as perceptual/behavioral. clinical/neurological. electrophysiological and "real time" methods of assessment of cerebral orientation have been made. Individual differences have been considered in relation to statistical concepts in the assessment of cerebral lateralization. Some emphasis has been placed on the application of these methods and concepts to psychopathology.




The Two Sides of Perception


Book Description

Anatomically, the central nervous system looks remarkably symmetrical--from the relatively simple structures of the spinal cord to the extensively convoluted folds of the cerebral hemispheres. At the functional level, however, there are striking differences between the left and right hemispheres. Although popular writings attribute language abilities to the left hemisphere and spatial abilities to the right, differences in hemispheric function appear to be more subtle. According to Ivry and Robertson, asymmetries over a wide range of perceptual tasks reflect a difference in strength rather than kind, with both hemispheres contributing to the performance of complex tasks, whether linguistic or spatial. After an historical introduction, the authors offer a cognitive neuroscience perspective on hemispheric specialization in perception. They propose that the two hemispheres differ in how they filter task-relevant sensory information. Building on the idea that the hemispheres construct asymmetric representations, the hypothesis provides a novel account of many laterality effects. A notable feature of the authors' work is their attempt to incorporate hemispheric specialization in vision, audition, music, and language within a common framework. In support of their theory, they review studies involving both healthy and neurologically impaired individuals. They also provide a series of simulations to demonstrate the underlying computational principles of their theory. Their work thus describes both the cognitive and neurological architecture of hemispheric asymmetries in perception.




Laterality Functional Asymmetry in the Intact Brain


Book Description

Laterality: Functional Asymmetry in the Intact Brain focuses on brain function and laterality as well as the various methods in assessing behavioral asymmetries, including handedness. It reviews the literature on perceptual-cognitive laterality effects in different sensory modalities, the lateralization of emotion and motor behavior, and the electrophysiological evidence. It also highlights some of the problems with the existing research and offers suggestions about the direction of future research. Organized into 17 chapters, this volume begins with an overview of cerebral asymmetry and the origins and mechanisms of lateralization. Then, it discusses the individual differences in laterality, methods and measurement used in laterality studies, and experiments on dichotic listening and auditory lateralization. The next chapters focus on the link between verbal laterality and handedness, tactual and perceptual laterality, asymmetry of motor performance, lateralization of emotional processes, and physiological measures of asymmetry. The book also introduces the handedness and its relation to cerebral function, genetics of laterality, development of cerebral lateralization, individual differences in cerebral organization, sex differences in laterality, reading- and language-related deficits, and control of the active hemisphere before concluding with a chapter discussing the experimental or strategy effects, the concept of complementary specialization, and the dichotomy between the two hemispheres of the brain. This book is a valuable resource for neuropsychologists, experimental psychologists, neurologists, and educators interested in understanding human brain function.




Art, Perception, and Reality


Book Description

Explores questions relating to the nature of representation in art. It asks how we recognize likeness in caricatures or portraits, for instance, and presents the conflicting arguments and opinions of an art historian, a psychologist and a philosopher.







Discovering the Brain


Book Description

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."




Neurobiology of Language


Book Description

Neurobiology of Language explores the study of language, a field that has seen tremendous progress in the last two decades. Key to this progress is the accelerating trend toward integration of neurobiological approaches with the more established understanding of language within cognitive psychology, computer science, and linguistics. This volume serves as the definitive reference on the neurobiology of language, bringing these various advances together into a single volume of 100 concise entries. The organization includes sections on the field's major subfields, with each section covering both empirical data and theoretical perspectives. "Foundational" neurobiological coverage is also provided, including neuroanatomy, neurophysiology, genetics, linguistic, and psycholinguistic data, and models. - Foundational reference for the current state of the field of the neurobiology of language - Enables brain and language researchers and students to remain up-to-date in this fast-moving field that crosses many disciplinary and subdisciplinary boundaries - Provides an accessible entry point for other scientists interested in the area, but not actively working in it – e.g., speech therapists, neurologists, and cognitive psychologists - Chapters authored by world leaders in the field – the broadest, most expert coverage available