Industrial and Environmental Xenobiotics


Book Description

The book you are just going to read represents the greater part of the papers presented at the International Conference on Industrial and En vironmental Xenobiotics, held in Prague, 1980, and some contributions by those who could not come. The first aim of the meeting was to fol low the tradition set up by the first conference in 1977. Again, we in vited biochemists, pharmacologists, and toxicologists from both East and West, who were involved in the study of disposition, biotransforma tion, and toxicity of important kinds of industrial and environmental pollutants, to promote the exchange of ideas and opinions on priorities in this area of the study of human environment. The invited contributions offer an excellent survey of and pro found insight into specific areas of toxicology and disposition of metals and organic chemicals, and the series of papers on specific subjects bring fresh information on the biotransformation and mechanisms of toxic action of several industrially important solvents tmd monomers of plastics. Rather than from the Preface, the reader should seek guidance from the Index, which clearly shows the overlapping of this area of toxicology with the latest results in biochemistry. We gratefully acknowledge the understanding, care, and preciSion of the publisher that made this book possible. The Editors Contents Metals Metabolic Factors in the Distribution and Half Time of Mercury After Exposure to Different Mercurials 1. Magos. With 1 Figure . . . . . . . . . . . . . . . . . . .. . . . 1 . . . . . Biliary Excretion of Metals M. Cikrt. With 9 Figures. . . . . . . . . . . . . . . . . . . .. . . 17 . . . . .




Information Resources in Toxicology


Book Description

History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...










Current Catalog


Book Description

First multi-year cumulation covers six years: 1965-70.




Xenobiotics in the Soil Environment


Book Description

This book describes the vast variety of xenobiotics, such as pesticides, antibiotics, antibiotic resistance genes, agrochemicals and other pollutants, their interactions with the soil environment, and the currently available strategies and techniques for soil decontamination and bioremediation. Topics covered include: transport mechanisms of pollutants along the Himalayas; use of earthworms in biomonitoring; metagenomic strategies for assessing contaminated sites; xenobiotics in the food chain; phyto-chemical remediation; biodegradation by fungi; and the use of enzymes and potential microbes in biotransformation. Accordingly, the book offers a valuable guide for scientists in the fields of environmental ecology, soil and food sciences, agriculture, and applied microbiology.










Fundamentals of Toxicologic Pathology


Book Description

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. - 25% brand new information, fully revised throughout - New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology - New color photomicrographs detailing specific toxicant-induced diseases in animals - Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels




Intentional Human Dosing Studies for EPA Regulatory Purposes


Book Description

The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.