Innovations in Chemical Biology


Book Description

This book includes 49 chapters presented as plenary , invited lectures and posters at the conference. Six plenary lectures have published in an issue of Pure and Applied Chemistry, Vol. 79, No. 12, 2007; the titles of these presentations are given as an Annex at the end of the book. I thank all contrib utors for the preparation of their presentations. It is sad to report that Professor Hitoshi Ohtaki, one of the founders of the Eurasia conferences and contributors passed away on November 5, 2006. Professor Ohtaki enthusiastically promoted international cooperation and took it upon himself to p- licize Japanese science to the wider world. His contribution in this book will serve as a memorable contribution to that goal. He will be missed by all of us. This book is dedicated to his memory. Professor Dr . Bilge S ̧ ener Editor Memorial Tribute to Professor Dr. Hitoshi Ohtaki Curriculum Vitae of Hitoshi Ohtaki Date of Birth September 16, 1932 Place of Birth T ok yo, Japan Date of Decease November 5, 2006 (at the age of 74) Addr ess 3-9-406 Namiki-2-chome, Kanazawa-ku, Yokohama, Japan Institution Chair Professor of The Research Organization of Science and Engineering, Ritsumeikan University Guest Professor of Yokohama City University Education Bachelor of Science, Nagoya University, 1955 Master of Science, Nagoya University, 1957 Doctor of Science, Nagoya University, 1961 ix x Memorial Tribute to Professor Dr.




Biotechnological Innovations in Chemical Synthesis


Book Description

A self-study textbook for technicians seeking further education, graduates extending their knowledge base, experienced workers facing changes in jobs, managers unfamiliar with the new technology, and people returning after a career break. Explores some ways biotechnology can provide new routes for producing traditional organic chemical products and enable new products to replace those with environmental or other drawbacks. The aspects discussed include a biocatalyst in organic synthesis, the efficiency of growth and product formation, the production and diversification of antibiotics, and the industrial production of amino acids by fermentation and chemo-enzymatic methods.




Mass Spectrometry in Chemical Biology


Book Description

Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core chapters build on basic concepts introduced in the opening chapter and explore established fields such as high throughput screening, proteomics and metabolomics. Emerging applications of mass spectrometry in elucidating biosynthetic pathways, enzyme mechanisms and protein-protein interactions are then presented. Connections between these diverse research fields are highlighted throughout. The book concludes with a discussion of databases and future perspectives. This book will be a useful tool to early chemical biology researchers wishing to incorporate mass spectrometry as a tool in their research.




Advances in Chemical Biology – An Approach In Future Perspectives Volume – 3


Book Description

Advances in Chemical Biology – Volume 3 The current book summary envisages the basic aspects of chemistry and biology thoughts, with the allied area of multidiscipline which comprises applications of chemical and biological disciplines and these are significant literatureto innovative minds to enrich their knowledge by research topics as anilluminative element to focus it in their research studies in the field of sciences. The book highlights research objectives on synthetic chemistry, newer approach of synthesis process and their various applications in in vitro and in vivo level as per the pharmaceutical industry requirements for commercialize the product to cure the various diseases and ailments for science and society. Recent innovations are highly applied and as per the demand of pharma sector and these are new perspectives to troubleshoot the newer problems with the help of molecular approach and bioinformatics applications.Understanding by the assimilation of basic to applied core research concepts in chemistry and their allied branches brings many applications, using novel methodologies, classic principles, defined protocols, emerging technologies by knowing similar issues and their impact in current-day problems in the science field. Hence, it’s multidisciplinary research to emphasize novel synthetic molecules which exhibit to safer, cheaper, and ecological drug for futuremedicine. The applications aimed on humans and animals as an important therapeutic drug for pharma industry. It is highly comprehensive book volume summarising various features of An Approach to Future Perspectives for academic research and industrial research in advanced level for all the learners in the area of chemistry and biology. It would be the best literature for the researchers and it can be a key reference book for the findings of new research problems to work for new drug discovery. This book has been peer-reviewed and free from plagiarism; hence it is highly useful for science and technology. It’s our great pleasure to wish all the readers, researchers, and industrialists to utilize it to accomplish new milestones as an innovation and novel discovery for future perspectives.




Advances in Chemical Biology- An Insight to New Applications and Developments Volume – 1


Book Description

Advancesin chemical and biological sciences are together contributing as organic molecules by the natural or synthetic sources with the research insight of scientific touch to make it as innovative ideas, process, protocols, products, and technologies for industrial applications. These conceptualapplications are useful to determine the next generation organic molecules againstcardiovascular, degenerative, infectious, neurological diseases with the valid dataneeded to prove its technical efficiency by the comparing standard drugs. Emerging any drugs from the origin of organic drugs are having more importance in the industries due to their efficacyand target to regulate or recover the health issues, these novel drugs may be inthe form of enzymes, metabolites, proteins, hormones or call it as biologicallyderived organic molecules. Most of the organic molecule findings are used toanalyze their hypotheses, mechanism of action, experimental design and theirbiological properties to derive functional aspects. To know these molecules structuralconfiguration various techniques and technology used and it is essential to becharacterizing the molecule by the chromatography, spectroscopy, etc., to confirmand further biological studies to know the properties. In this context this editedcomprehensive book brings the current innovation in the organic molecules withthe updates of various biological applications and covering the area of agriculture,biotechnology, microbiology, neutraceutics, nanotechnology, pharmacology, synthetic medicinal chemistry etc., based applicative research data to reviewed extensivelyin narrative loom. Highlights of the chapters are novel experimental protocol, methodology, techniques, study concepts, used advanced tools and statistical analysisfor the use of organic molecules to know their biological properties. The book possessing 9 chapters covering chemistry and biological investigations on theorganic molecules with the updated innovative findings, principles of the molecules,molecular targets, also interactions with cell lines, microorganisms and animalmodels which persuade remedial measures as preclinical and clinical studies. Book also focused on types of synthesis, advanced extractions, use of analyticaltools, purification schemes, characterization methods and data analytics.It is a designed as comprehensive reference book for all the grade &level of researchersto use it as experimental handbook or manual to work on the similar areas, it isalso useful for the creative scholars to obtain research experience and enhancethe skills by updating themselves as need of hour, also know the timely outbreaksto combat by such organic molecules as emerging drugs to be in a bio-innovationforum.




Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism


Book Description

This book arises from the NATO Advanced Study Institute “Technological Innovations in Detection and Sensing of CBRN Agents and Ecological Terrorism” held in Chisinau, Republic of Moldova in June 2010. It comprises a variety of invited contributions by highly experienced educators, scientists, and industrialists, and is structured to cover important aspects of the field that include developments in chemical-biological, and radiation sensing, synthesis and processing of sensors, and applications of sensors in detecting/monitoring contaminants introduced/dispersed inadvertently or intentionally in air, water, and food supplies. The book emphasizes nanomaterials and nanotechnology based sensing and also includes a section on sensing and detection technologies that can be applied to information security. Finally, it examines regional, national, and international policies and ethics related to nanomaterials and sensing. It will be of considerable interest and value to those already pursuing or considering careers in the field of nanostructured materials and nanotechnology based sensing, In general, it serves as a valuable source of information for those interested in how nanomaterials and nanotechnologies are advancing the field of sensing, detection, and remediation, policy makers, and commanders in the field.




Industrialization of Biology


Book Description

The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.




Advanced Chemical Biology


Book Description

Advanced Chemical Biology The modern approach to teaching chemical biology Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like: DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer. With a Foreword by Nobel Laureate Carolyn Bertozzi.




Advances in Chemical Biology – An Overview of Research Milestones and Applications (Volume – II) Book


Book Description

The current book emphasizes on basic knowledge of chemistry and biology concepts, covering multidisciplinary applications which comprises functional aspects of chemical and biological disciplines and they are resource material for young innovative minds to enhance their knowledge and research thoughts as a creative element to apply it in their research in the field of chemical biology. The main motto of this book highlights on research objectives, new developments of synthesis, a wide range of applications, and as per the industrial requirements for a useful product to launch or discover for science and society. Various innovations are the major source and new perspectives to troubleshoot the newer problems with the help of allied science applications by understanding the basic concepts, theories, protocols, needful technologies, and applied products, by knowing similar problems and their impact in current-day problems in the science field. Hence, it’s interdisciplinary research to develop highly significant pharmacology products in the areas of life science to make sure safer, cheaper, and ecological as a novel future drug/medicine. The applications aimed mainly to health of humans, health of agro-horticulture, health of environment and animalsas well as wealth of entrepreneurs. This comprehensive edited volume summarises the features of An Approach to Future Perspectives for academic, research and industrial purposes as an advanced reference material for all the learners in the area of chemistry and biology.




Innovations in Biomolecular Modeling and Simulations


Book Description

The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.