Insights in Brain Imaging Methods: 2023


Book Description

Following on from the success of Insights in Brain Imaging Methods: 2021, we would like to further celebrate the exceptional achievements made by scientists, leading to major advancements in the fast-growing field of neuroscience. You can find the 2021 edition here. Frontiers is continuing to organize a series of Research Topics to highlight the latest advancements in research across the field of neuroscience, with articles from the members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Prof Vince D Calhoun, Specialty Chief Editor of the Brain Imaging Methods section, together with Professors Federico Giove and Xi-Nian Zuo, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Brain Imaging Methods.




Advanced Optical Methods for Brain Imaging


Book Description

This book highlights the rapidly developing field of advanced optical methods for structural and functional brain imaging. As is known, the brain is the most poorly understood organ of a living body. It is indeed the most complex structure in the known universe and, thus, mapping of the brain has become one of the most exciting frontlines of contemporary research. Starting from the fundamentals of the brain, neurons and synapses, this book presents a streamlined and focused coverage of the core principles, theoretical and experimental approaches, and state-of-the-art applications of most of the currently used imaging methods in brain research. It presents contributions from international leaders on different photonics-based brain imaging modalities and techniques. Included are comprehensive descriptions of many of the technology driven spectacular advances made over the past few years that have allowed novel insights of the structural and functional details of neurons. The book is targeted at researchers, engineers and scientists who are working in the field of brain imaging, neuroscience and connectomics. Although this book is not intended to serve as a textbook, it will appeal to undergraduate students engaged in the specialization of brain imaging.




New Insights into Brain Imaging Methods for Rehabilitation of Brain Diseases


Book Description

Brain diseases such as stroke, Alzheimer's disease, and Parkinson's disease cause dysfunction in multiple body systems. Motor dysfunction, cognitive impairment, dysphagia, and emotion disorders are frequently observed in patients with brain diseases. As the dysfunctions are associated with alterations in the brain, brain imaging methods such as functional MRI (fMRI), electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and transcranial magnetic stimulation (TMS) are essential for investigating the neural mechanisms underlying the dysfunction caused by brain diseases. Brain imaging methods are also critical for understanding the neural mechanisms for the effectiveness of therapeutic or rehabilitative interventions that promote recovery from brain diseases. The usage of these brain imaging methods would deepen our understanding of brain diseases and potentially translate this knowledge to improve effectiveness of rehabilitative interventions for brain diseases.




Brain Imaging in Behavioral Neuroscience


Book Description

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.







Imaging the Brain with Optical Methods


Book Description

Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50–100 μm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function.




Stroke Rehabilitation


Book Description

Stroke Rehabilitation: Insights from Neuroscience and Imaging informs and challenges neurologists, rehabilitation therapists, imagers, and stroke specialists to adopt more restorative and scientific approaches to stroke rehabilitation based on new evidence from neuroscience and neuroimaging literatures. The fields of cognitive neuroscience and neuroimaging are advancing rapidly and providing new insights into human behavior and learning. Similarly, improved knowledge of how the brain processes information after injury and recovers over time is providing new perspectives on what can be achieved through rehabilitation. Stroke Rehabilitation explores the potential to shape and maximize neural plastic changes in the brain after stroke from a multimodal perspective. Active skill based learning is identified as a central element of a restorative approach to rehabilitation. The evidence behind core learning principles as well as specific learning strategies that have been applied to retrain lost functions of movement, sensation, cognition and language are also discussed. Current interventions are evaluated relative to this knowledge base and examples are given of how active learning principles have been successfully applied in specific interventions. The benefits and evidence behind enriched environments is reviewed with examples of potential application in stroke rehabilitation. The capacity of adjunctive therapies, such as transcranial magnetic stimulation, to modulate receptivity of the damaged brain to benefit from behavioral interventions is also discussed in the context of this multimodal approach. Focusing on new insights from neuroscience and imaging, the book explores the potential to tailor interventions to the individual based on viable brain networks.







Dynamic Brain Imaging


Book Description

If a picture is worth a thousand words, then dynamic images of brain activity certainly warrant many, many more. This book will help users learn to decipher the dynamic imaging data that will be critical to our future understanding of complex brain functions. In recent years, there have been unprecedented methodological advancements in the imaging of brain activity. These techniques allow the measurement of everything from neural activity (e.g., membrane potential, ion ?ux, neurotransmitter ?ux) to energy metabolism (e.g., glucose consumption, oxygen consumption, creatine kinase ?ux) and functional hyperemia (e.g., blood ?ow, volume, oxygenation). This book deals with a variety of magnetic resonance, electrophysiology, and optical methods that are often used to measure some of these dynamic processes. All chapters were written by leading experts, spanning three continents, specializing in state-of-the-art methods. Brie?y, the book has ?ve sections. In the introductory section, there are two chapters; the ?rst one contains a brief pre- ble to dynamic brain imaging and the other presents a novel, analytical approach to processing of dynamically acquired data. The second section has four chapters and delves into a wide range of optical imaging methods. I am privileged to include a chapter from Lawrence B. Cohen, considered by many to be the authority on optical imaging and spectroscopy, both in vitro and in vivo [Cohen LB (1973) Physiol Rev.