International Classification of Rodent Tumors. The Mouse


Book Description

Scientists from both academia and industry in many countries have closely cooperated to arrive at a consensus on the descriptions of all the types of tumour and preneoplastic lesions encountered in laboratory mice. The series of fascicles should provide information and guidelines especially adapted for international use in practical toxicologic pathology. Images showing the typical appearance of the discussed lesions and references to the most recently published papers complete the information presented here.










Histopathology of Preclinical Toxicity Studies


Book Description

Chapter 1: Introduction -- Chapter 2: Integumentary System -- -- Skin and subcutaneous tissue -- Chapter 3: Mammary Gland -- Chapter 4: Haemopoietic and Lymphatic Systems -- -- Blood/bone marrow -- -- Lymphoid system -- -- Lymph nodes -- -- Spleen -- -- Thymus -- -- Lymphoreticular neoplasms -- Chapter 5: Musculoskeletal System -- -- Bone -- -- Joints -- -- Skeletal muscle -- Chapter 6: Respiratory Tract -- -- Nose, nasal sinuses, nasopharynx and pharynx -- -- Larynx and trachea -- -- Bronchi and lungs -- Chapter 7: Cardiovascular System -- -- Heart and pericardium -- -- Systemic blood vessels -- -- Pulmonary blood vessels -- Chapter 8: Gastrointestinal tract -- -- Forestomach -- -- Stomach (glandular) -- -- Small intestine -- -- Large intestine -- Chapter 9: Liver and Pancreas -- -- Liver -- -- Bile ducts, biliary system -- -- Pancreas -- Chapter 10: Urinary System -- -- Kidney -- -- Urinary bladder -- Chapter 11: Male Genital Tract -- -- Prostate gland -- -- Epididymis -- -- Testis -- Chapter 12: Female Genital Tract -- -- Vagina -- -- Cervix -- -- Uterus -- -- Ovary -- Chapter 13: Endocrine System -- -- Pituitary gland -- -- Adrenal gland -- -- Thyroid gland -- -- Parathyroid gland -- Chapter 14: Nervous System and Special Sense Organs -- -- Brain -- -- Spinal cord, spinal nerve roots, peripheral nerves -- -- Eye -- -- Ear -- Subject index







Cancer Risk Assessment


Book Description

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.







Boorman's Pathology of the Rat


Book Description

Boorman's Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. - Contains full, four color photographs from the NTP archive and database and coverage of all rat strains - Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes - Includes comprehensive and detailed background incidence data - Presents detailed descriptive content regarding changes in rat models during research




Respiratory System


Book Description

Approximately ten years have elapsed since the second volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Respiratory System, was first completed. New in formation of interest to pathologists has developed at a rather remark able pace during these years. Exceptional progress has been made in the routine identification of enzymes and cell products in respiratory cells. A better understanding has developed on the functions of cells of the respiratory tract and of the mechanisms involved in cell metabolism, particularly those involving toxins and carcinogens. Clear concepts have developed concerning the significance of pathologic lesions, particularly in the upper respiratory tract and their relation to human health and risk assessment. Standardized nomenclature has developed significantly dur ing the lO-year period since the first edition and is being utilized on an international basis. This has resulted in significant improvement in com munication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have had significant effects on these improved communications and the international acceptance of standardized nomenclature. In this sec ond edition, new formats have been used where more appropriate for the subjects to be covered.