Interstitial and Intracavitary Thermoradiotherapy


Book Description

The use of hyperthermia in radiation oncology is well established. Many publications cover the whole field of possibilities and problems of this therapeutic modality. The new development of interstitial and intracavitary hyperthermia, however, is not well known: there are only a few relevant publications in different journals. Therefore, it was appropriate that SAUER and SEEGENSCHMIEDT organized an international meeting on this topic, where experiences with this new and promising technique were compiled and discussed by experts. The papers of this symposium together with additional review papers and clinical studies are published in this volume. The publication begins with the physical and biological background of interstitial and intracavitary hyperthermia continues with comprehensive review papers on clinical topics and then gives examples for a wide variety of clinical applications. This volume will contribute to better understanding and application of the treatment possibilities of radio oncology in combination with this new treatment modality.




Thermoradiotherapy and Thermochemotherapy


Book Description

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.




Thermoradiotherapy and Thermochemotherapy


Book Description

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy of ionizing radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Triple modality (thermo-chemo-radiotherapy) or other treatment combinations have not been fully evaluated and may demonstrate extended clinical applications in the future. Problems remain with regard to maximizing the effects of hyperthermia as they are influenced by a variety of external and intrinsic factors including bloodflow, microenvironment etc. While the previous volume has summarized more theoretical aspects of hyper thermia, i.e. biology, physiology and physics, the present volume compiles the current knowledge relative to the clinical applications of hyperthermia in combina tion with radiation therapy and/or chemotherapy, providing a comprehensive over view of its use in cancer management.




Physics of Thermal Therapy


Book Description

The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly for treatment of solid cancerous tumors using image guidance. The controlled application of thermal energy to living tissues has proven a great challenge, requiring expertise from multiple disciplines, thereby leading to the development of many sophisticated pre-clinical and clinical devices and treatment techniques. Physics of Thermal Therapy: Fundamentals and Clinical Applications captures the breadth and depth of this highly multidisciplinary field. Focusing on applications in cancer treatment, this book covers basic principles, practical aspects, and clinical applications of thermal therapy. An overview of the fundamentals shows how use of controlled heat in medicine and biology involves electromagnetics, acoustics, thermodynamics, heat transfer, and imaging sciences. The book discusses challenges in the use of thermal energy on living tissues and explores the genetic, cellular, and physiological responses that can be employed in the fight against cancer from the physics and engineering perspectives. It also highlights recent advances, including the treatment of solid tumors using image-guided thermal therapy, microbubbles, nanoparticles, and other cutting-edge techniques.




Interstitial and Intracavitary Thermoradiotherapy


Book Description

The use of hyperthermia in radiation oncology is well established. Many publications cover the whole field of possibilities and problems of this therapeutic modality. The new development of interstitial and intracavitary hyperthermia, however, is not well known: there are only a few relevant publications in different journals. Therefore, it was appropriate that SAUER and SEEGENSCHMIEDT organized an international meeting on this topic, where experiences with this new and promising technique were compiled and discussed by experts. The papers of this symposium together with additional review papers and clinical studies are published in this volume. The publication begins with the physical and biological background of interstitial and intracavitary hyperthermia continues with comprehensive review papers on clinical topics and then gives examples for a wide variety of clinical applications. This volume will contribute to better understanding and application of the treatment possibilities of radio oncology in combination with this new treatment modality.




Principles and Technologies for Electromagnetic Energy Based Therapies


Book Description

Principles and Technologies for Electromagnetic Energy Based Therapies covers the theoretical foundations of electromagnetic-energy based therapies, principles for design of practical devices and systems, techniques for in vitro and in vivo testing of devices, and clinical application examples of contemporary therapies employing non-ionizing electromagnetic energy. The book provides in-depth coverage of: pulsed electric fields, radiofrequency heating systems, tumor treating fields, and microwave heating technology. Devices and systems for electrical stimulation of neural and cardiac issue are covered as well. Lastly, the book describes and discusses issues that are relevant to engineers who develop and translate these technologies to clinical applications. Readers can access information on incorporation of preclinical testing, clinical studies and IP protection in this book, along with in-depth technical background for engineers on electromagnetic phenomena within the human body and selected therapies. It covers both engineering and biological/medical materials and gives a full perspective on electromagnetics therapies. Unique features include content on tumor treating fields and the development and translation of biomedical devices. - Provides in-depth technical background on electromagnetic energy-based therapies, along with real world examples on how to design devices and systems for delivering electromagnetic energy-based therapies - Includes guidance on issues that are relevant for translating the technology to the market, such as intellectual property, regulatory issues, and preclinical testing - Companion site includes COMSOL models, MATLAB code, and lab protocols




Pediatric Uroradiology


Book Description

This fully updated and revised edition of a classic work takes full account of recent dramatic changes in the subject area. It describes in detail all aspects of pediatric uroradiology, embracing both recent developments and established concepts. New chapters have been added, for example on genetics in nephrourology and clinical management of important nephrourologic disorders. Short conclusions are included at the end of sections to provide the reader with key information.




High-Resolution Sonography of the Peripheral Nervous System


Book Description

Since the first edition of this book, sonography of the peripheral nervous system has evolved further. This second, revised edition includes many state-of-the-art high-resolution images, the text has been adapted to reflect the current state of the literature, and information is presented using a more modern layout. This book provides a practical, clinically oriented overview of all aspects of sonographic diagnosis and interventional therapy of the peripheral nervous system.




Imaging in Pediatric Skeletal Trauma


Book Description

This is a comprehensive textbook on the imaging of pediatric skeletal trauma. It gives radiologists and pediatric surgeons a detailed description of the techniques used as well as examples of the imaging findings and details of their clinical relevance. Each chapter is written by an expert in the field and includes a wealth of illustrations. The book provides invaluable advice on those features which will affect the orthopedic management of a child.




Intracranial Vascular Malformations and Aneurysms


Book Description

This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods or techniques employed in their treatment. Individual chapters are devoted to venous malformations, capillary telangiectasias and cavernomas, pial arteriovenous malformations, dural arteriovenous malformations, and intracranial aneurysms. Each chapter is subdivided into four principal sections on pathology, clinical presentation, diagnostic imaging, and therapy, ensuring a standardized approach throughout. The book is richly illustrated with numerous informative CT, MR and DSA images.