Author : Palmer, Lyle J.
Publisher : Policy Press
Page : 240 pages
File Size : 50,64 MB
Release : 2011-05-31
Category : Medical
ISBN : 1861348975
This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.
Author :
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Page : 240 pages
File Size : 29,8 MB
Release :
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ISBN : 1861348983
Author : Muin J. Khoury
Publisher : Monographs in Epidemiology and
Page : 394 pages
File Size : 19,50 MB
Release : 1993
Category : Medical
ISBN : 0195052889
This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
Author : Evangelos Evangelou
Publisher : Humana Press
Page : 299 pages
File Size : 19,23 MB
Release : 2018-06-07
Category : Medical
ISBN : 9781493978670
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
Author : Robert C. Elston
Publisher : John Wiley & Sons
Page : 860 pages
File Size : 48,34 MB
Release : 2002-04-22
Category : Medical
ISBN : 9780471486312
Human Genetics concerns the study of genetic forces in man. By studying our genetic make-up we are able to understand more about our heritage and evolution. Some of the original, and most significant research in genetics centred around the study of the genetics of complex diseases - genetic epidemiology. This is the third in a highly successful series of books based on articles from the Encyclopedia of Biostatistics. This volume will be a timely and comprehensive reference, for a subject that has seen a recent explosion of interest following the completion of the first draft of the Human Genome Mapping Project. The editors have updated the articles from the Human Genetics section of the EoB, have adpated other articles to give them a genetic feel, and have included a number of newly commissioned articles to ensure the work is comprehensive and provides a self-contained reference.
Author : Melinda C. Mills
Publisher : MIT Press
Page : 433 pages
File Size : 18,81 MB
Release : 2020-02-18
Category : Science
ISBN : 0262357445
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
Author : Bertram K. C. Chan
Publisher : Springer
Page : 368 pages
File Size : 16,16 MB
Release : 2018-10-24
Category : Medical
ISBN : 331993791X
The book illustrates how biostatistics may numerically summarize human genetic epidemiology using R, and may be used successfully to solve problems in quantitative Genetic Epidemiology Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications. Biostatistics for Human Genetic Epidemiology is an ideal reference for professionals and students in Medicine (particularly in Preventive Medicine and Public Health Medical Practices), as well as in Genetics, Epidemiology, and Biostatistics.
Author : John I. Nurnberger
Publisher : Cambridge University Press
Page : 415 pages
File Size : 50,56 MB
Release : 2012-09-13
Category : Medical
ISBN : 0521896495
A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.
Author : Paul A. Schulte
Publisher : Academic Press
Page : 609 pages
File Size : 38,25 MB
Release : 2012-12-02
Category : Medical
ISBN : 0323138578
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Author : Jørn Olsen
Publisher : Springer Science & Business Media
Page : 152 pages
File Size : 48,8 MB
Release : 2010-06-14
Category : Medical
ISBN : 1441914978
Today, the public worries about emerging diseases and rapid changes of the frequency of well known diseases like autism, diabetes and obesity making the word epidemic part of the general discussion. Epidemiology should therefore be a basic component of medical training, yet often it is undertaught or even neglected. Concise and readable while also rigorous and thorough, An Introduction to Epidemiology for Health Professionals goes beyond standard textbook content to ground the reader in scientific methods most relevant to the current health landscape and the evolution of evidence-based medicine—valuable keys to better understanding of disease process, effective prevention, and targeted treatment.
