Introduction to Strategies for Organic Synthesis


Book Description

The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.







Organic Chemistry Study Guide


Book Description

Organic Chemistry Study Guide: Key Concepts, Problems, and Solutions features hundreds of problems from the companion book, Organic Chemistry, and includes solutions for every problem. Key concept summaries reinforce critical material from the primary book and enhance mastery of this complex subject. Organic chemistry is a constantly evolving field that has great relevance for all scientists, not just chemists. For chemical engineers, understanding the properties of organic molecules and how reactions occur is critically important to understanding the processes in an industrial plant. For biologists and health professionals, it is essential because nearly all of biochemistry springs from organic chemistry. Additionally, all scientists can benefit from improved critical thinking and problem-solving skills that are developed from the study of organic chemistry. Organic chemistry, like any "skill", is best learned by doing. It is difficult to learn by rote memorization, and true understanding comes only from concentrated reading, and working as many problems as possible. In fact, problem sets are the best way to ensure that concepts are not only well understood, but can also be applied to real-world problems in the work place. - Helps readers learn to categorize, analyze, and solve organic chemistry problems at all levels of difficulty - Hundreds of fully-worked practice problems, all with solutions - Key concept summaries for every chapter reinforces core content from the companion book







Introduction to Organic Geochemistry


Book Description

An Introduction to Organic Geochemistry explores the fate of organic matter of all types, biogenic and man-made, in the Earth System. investigates the variety of pathways and biogeochemical transformations that carbon compounds can experience over a range of time scales and in different environments scope widened to provide a broad and up-to-date background - structured to accommodate readers with varied scientific backgrounds essential terminology is defined fully and boxes are used to explain concepts introduced from other disciplines further study aided by the incorporation of carefully selected literature references It investigates the variety of pathways and biogeochemical transformations that carbon compounds can experience over a range of time scales and in different environments.




Organic Chemistry


Book Description

Organic chemistry is the chemistry of compounds of carbon. The ability of carbon to link together to form long chain molecules and ring compounds as well as bonding with many other elements has led to a vast array of organic compounds. These compounds are central to life, forming the basis for organic molecules such as nucleic acids, proteins, carbohydrates, and lipids. In this Very Short Introduction Graham Patrick covers the whole range of organic compounds and their roles. Beginning with the structures and properties of the basic groups of organic compounds, he goes on to consider organic compounds in the areas of pharmaceuticals, polymers, food and drink, petrochemicals, and nanotechnology. He looks at how new materials, in particular the single layer form of carbon called graphene, are opening up exciting new possibilities for applications, and discusses the particular challenges of working with carbon compounds, many of which are colourless. Patrick also discusses techniques used in the field. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.




Practical Process Research and Development


Book Description

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to - Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" - Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more - Presents guidelines for implementing and troubleshooting processes




Introduction to Strategies for Organic Synthesis


Book Description

Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions Helps students envision forward reactions and backwards disconnections as a matter of routine Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions Provides clear explanations in easy-to-follow, student-friendly language Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.




Introduction to Analytical Methods in Organic Geochemistry


Book Description

All sub disciplines in Organic Geochemistry (Petroleum Geochemistry, Environmental Geochemistry etc.) are linked by the basic analytical approaches used for identification and quantitation of individual organic substances. Hence, a fundamental prerequisite for organic geochemists is the knowledge not only about the individual analytical techniques but more about their potential as well as their limitations. In this issues basic analytical procedures and techniques are introduced comprising fundamental steps like sampling and sample storage, aspects of sample treatment like extraction and fractionation procedures and finally the specific techniques used for organic analyses on partially very low concentration levels such as mass spectrometry or infrared spectroscopy. Beside the technical aspects also application on organic-geochemical problems and the standard data evaluation practice is introduced. Finally, special chapters point to analytical pitfalls and to principal standard operation procedures. The intention of this issue is to get the readers familiar with analytical Organic Geochemistry and to enable them to assess the quality and suitability of specific analytical approaches, in particular with respect to the organic-geochemical problems.




Classics in Total Synthesis III


Book Description

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.