Modeling Life


Book Description

This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?




Models of Life


Book Description

An overview of current models of biological systems, reflecting the major advances that have been made over the past decade.




Models of My Life


Book Description

In this candid and witty autobiography, Nobel laureate Herbert A. Simon looks at his distinguished and varied career, continually asking himself whether (and how) what he learned as a scientist helps to explain other aspects of his life. A brilliant polymath in an age of increasing specialization, Simon is one of those rare scholars whose work defines fields of inquiry. Crossing disciplinary lines in half a dozen fields, Simon's story encompasses an explosion in the information sciences, the transformation of psychology by the information-processing paradigm, and the use of computer simulation for modeling the behavior of highly complex systems. Simon's theory of bounded rationality led to a Nobel Prize in economics, and his work on building machines that think—based on the notion that human intelligence is the rule-governed manipulation of symbols—laid conceptual foundations for the new cognitive science. Subsequently, contrasting metaphors of the maze (Simon's view) and of the mind (neural nets) have dominated the artificial intelligence debate. There is also a warm account of his successful marriage and of an unconsummated love affair, letters to his children, columns, a short story, and political and personal intrigue in academe.




Accelerated Life Models


Book Description

The authors of this monograph have developed a large and important class of survival analysis models that generalize most of the existing models. In a unified, systematic presentation, this monograph fully details those models and explores areas of accelerated life testing usually only touched upon in the literature. Accelerated Life Models:




Artificial Life Models in Hardware


Book Description

Hopping, climbing and swimming robots, nano-size neural networks, motorless walkers, slime mould and chemical brains - "Artificial Life Models in Hardware" offers unique designs and prototypes of life-like creatures in conventional hardware and hybrid bio-silicon systems. Ideas and implementations of living phenomena in non-living substrates cast a colourful picture of state-of-art advances in hardware models of artificial life.




Model Based Inference in the Life Sciences


Book Description

This textbook introduces a science philosophy called "information theoretic" based on Kullback-Leibler information theory. It focuses on a science philosophy based on "multiple working hypotheses" and statistical models to represent them. The text is written for people new to the information-theoretic approaches to statistical inference, whether graduate students, post-docs, or professionals. Readers are however expected to have a background in general statistical principles, regression analysis, and some exposure to likelihood methods. This is not an elementary text as it assumes reasonable competence in modeling and parameter estimation.




Artificial Life Models in Software


Book Description

The advent of powerful processing technologies and the advances in software development tools have drastically changed the approach and implementation of computational research in fundamental properties of living systems through simulating and synthesizing biological entities and processes in artificial media. Nowadays realistic physical and physiological simulation of natural and would-be creatures, worlds and societies becomes a low-cost task for ordinary home computers. The progress in technology has dramatically reshaped the structure of the software, the execution of a code, and visualization fundamentals. This has led to the emergence of novel breeds of artificial life software models, including three-dimensional programmable simulation environment, distributed discrete events platforms and multi-agent systems. This second edition reflects the technological and research advancements, and presents the best examples of artificial life software models developed in the World and available for users.




Artificial Life Models in Software


Book Description

An informal introduction and guidance to modern software tools for modeling and simulation of life-like phenomena, this book offers detailed reviews of contemporary software for artificial life for both professionals and amateurs.




The Life and Ship Models of Norman Ough


Book Description

“Brings Ough’s life and work beautifully to light in a volume rich in photographs, drawings, technical detail and personality.”—Schopenhauer’s Workshop Norman Ough is considered by many as simply the greatest ship modeler of the twentieth century and his exquisite drawings and meticulous models have come to be regarded as masterpieces of draughtsmanship, workmanship and realism; more than technically accomplished ship models, they are truly works of art. This new book is both a tribute to his lonely genius and a practical treatise for model shipwrights. Ough lived most of his adult life far from the sea in a flat high above the Charing Cross Road in London, where his frugal existence and total absorption in his work led to hospitalization on at least two occasions; he was an eccentric in the truest sense but he also became one of the most sought-after masters of his craft. Earl Mountbatten had him model the ships he had served on; his model of HMS Queen Elizabeth was presented to Earl Beatty; film production companies commissioned models for effects in several films. Incorporating many of his original articles from Model Maker Magazine, his detailed line drawings now kept in the Brunel Institute, and photographs of his models held in museums and at Mountbatten’s house, this book presents an inspiring panorama of perhaps the most perfect warship models ever made. “An amazing, almost intimidating view of the method, modelling, drawings, and a life of a builder so obsessed with his work that some may say he was a man who went down with his ships.”—FineScale Modeler




Life Models


Book Description

David Michaels, a solitary widower, is a returning college student who models nude for art classes part time. He gets more than he bargained for when he shares the platform with another model, the sometimes wild and always vivacious Lydia Nelson.