Artificial Intelligence and Machine Learning for Digital Pathology


Book Description

Data driven Artificial Intelligence (AI) and Machine Learning (ML) in digital pathology, radiology, and dermatology is very promising. In specific cases, for example, Deep Learning (DL), even exceeding human performance. However, in the context of medicine it is important for a human expert to verify the outcome. Consequently, there is a need for transparency and re-traceability of state-of-the-art solutions to make them usable for ethical responsible medical decision support. Moreover, big data is required for training, covering a wide spectrum of a variety of human diseases in different organ systems. These data sets must meet top-quality and regulatory criteria and must be well annotated for ML at patient-, sample-, and image-level. Here biobanks play a central and future role in providing large collections of high-quality, well-annotated samples and data. The main challenges are finding biobanks containing ‘‘fit-for-purpose’’ samples, providing quality related meta-data, gaining access to standardized medical data and annotations, and mass scanning of whole slides including efficient data management solutions.




Fornaldarsagaerne


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The Annenbergs


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"This is the colorful and dramatic biography of two of America's most controversial entrepreneurs: Moses Louis Annenberg, 'the racing wire king, ' who built his fortune in racketeering, invested it in publishing, and lost much of it in the biggest tax evasion case in United States history; and his son, Walter, launcher of TV Guide and Seventeen magazines and former ambassador to Great Britain."--Jacket.




RNA Exosome


Book Description

The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.




Screening Donated Blood for Transfusion-transmissible Infections


Book Description

"Blood transfusion is a life-saving intervention that has an essential role in patient management within health care systems. All Member States of the World Health Organization (WHO) endorsed World Health Assembly resolutions WHA28.72 (1) in 1975 and WHA58.13 (2) in 2005. These commit them to the provision of adequate supplies of safe blood and blood products that are accessible to all patients who require transfusion either to save their lives or promote their continuing or improving health." --Preface.




Facsimile Products


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Heart-life in Song


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Mad about Madeline


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2028 End


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God created a game - it's called The Game of Life. Planet Earth is the playing field, the 10 love commandments are the rules, and we humans are the players who can win or lose. The game is played by two teams, like the game of football. One team's head coach is Jesus and the other team's head coach is Satan. All of us on earth are playing for one of these two teams! Gabriel Ansley Erb wrote the book "2028 END" in order to fully elucidate God's game clock scenario for The Game of Life as contained in the game's handbook, the Holy Bible. The handbook says, "God declared the end from the beginning" (Isaiah 46:10) by using 7 days in the creation event. Each 24 hour creation day foretold of a future 1,000 year period for a total 7,000 year plan God had for The Game of Life to be played on planet earth. And amazingly, to confirm this is all true, God hid a secret prophesy in each creation day foretelling the greatest event He had planned to occur in that day's future millennium!Consequently, Creation day 1 foretold Adam & Eve's fall, which was fulfilled during earth's 1st millennium. Creation day 2 foretold Noah's global flood, which was fulfilled during earth's 2nd millennium. Creation day 3 foretold Moses' Red Sea parting, which was fulfilled during earth's 3rd millennium. Creation day 4 foretold of John the Baptist & Jesus Christ, and so they lived and died during earth's 4th millennium. And the prophecies continue with each Creation day!Gabriel proves all of the above, carefully revealing the prophetic Scriptures as well as the fulfillment Scriptures. Then he reveals a dozen Scriptures proving Christ died earth's 4,000 year and will return earth's 6,000 year. Finally, he proves Christ died Feast of Passover AD 28 and will return Feast of Trumpets 2028. For those who read this book, it is an open and shut case: The Game of Life will end 2,000 years from the year of Christ's death on the cross - AD 2028.