Mechanism of Chromatin Reassembly at the Yeast PHO5 Promoter Upon Repression
Author : Ulrike Schermer
Publisher :
Page : 0 pages
File Size : 10,78 MB
Release : 2007
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ISBN :
Author : Ulrike Schermer
Publisher :
Page : 0 pages
File Size : 10,78 MB
Release : 2007
Category :
ISBN :
Author : Ulrike Schermer
Publisher :
Page : 202 pages
File Size : 36,86 MB
Release : 2006
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Author : Elizabeth S. Haswell
Publisher :
Page : 304 pages
File Size : 25,5 MB
Release : 2000
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Author : Sarah C. R. Elgin
Publisher : Frontiers in Molecular Biology
Page : 372 pages
File Size : 27,47 MB
Release : 2000
Category : Chromatin
ISBN : 9780199638901
Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Author : Walter Joseph Jessen
Publisher :
Page : pages
File Size : 20,92 MB
Release : 2006
Category :
ISBN :
In eukaryotes, the organization of DNA into chromatin is a primary determinant of gene expression. Positioned nucleosomes in promoter regions are frequently found to regulate gene expression by obstructing the accessibility of cis-regulatory elements in DNA to trans-factors. This dissertation focuses on the chromatin structure and remodeling program at the S. cerevisiae PHO5 promoter, extending the use of DNA methyltransferases as in vivo probes of chromatin structure. Our studies address the diversity of histone-DNA interactions in vivo by examining nucleosome conformational stabilities at the PHO5 promoter. We present high-resolution chromatin structural mapping of the promoter, required to relate in vivo site accessibility to nucleosome stability and show that the PHO5 promoter nucleosomes have different accessibilities. We show a correlation between DNA curvature and nucleosome positioning, which is consistent with the observed differences in accessibility/stability. Kinetic analyses of the chromatin remodeling program at PHO5 show that nucleosomes proximal to the enhancer are disrupted preferentially and prior to those more distal, demonstrating bidirectional and finite propagation of chromatin remodeling from bound activators and providing a novel mechanism by which transactivation at a distance occurs.
Author : Randall H. Morse
Publisher : Academic Press
Page : 586 pages
File Size : 45,82 MB
Release : 2024-06-15
Category : Science
ISBN : 0128148101
Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. Provides a current, expansive, and well-documented resource on chromatin and epigenetics Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward
Author : Karsten Rippe
Publisher : John Wiley & Sons
Page : 597 pages
File Size : 40,91 MB
Release : 2012-01-09
Category : Science
ISBN : 3527640002
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Author : Jerry L. Workman
Publisher : Springer Science & Business Media
Page : 594 pages
File Size : 15,92 MB
Release : 2013-12-04
Category : Medical
ISBN : 1461486246
While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.
Author :
Publisher :
Page : 1206 pages
File Size : 49,69 MB
Release : 2006
Category : Biochemistry
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Author :
Publisher :
Page : 886 pages
File Size : 16,88 MB
Release : 2006
Category : Dissertations, Academic
ISBN :