Mechanisms of Metallocenter Assembly


Book Description

The authors discuss the importance of metallocenter assembly in the activation of several enzymes and selected structural proteins. The possible reasons why expression of the structural gene is not enough to obtain a functional metalloprotein also are well covered. Mechanisms of Metallocenter Assembly currently is the only book that brings together experimental findings previously scattered in the literature on the mechanisms of metal incorporation into proteins.




Transition Metals in Microbial Metabolism


Book Description

The key role played by iron, as well as other transition metals, in microbial metabolism is investigated in this volume. Topics covered include: iron chelation and siderophores; receptor-mediated bacterial iron transport; and the nitogenases.




Metals and Genetics


Book Description

During the past few years, major scientific discoveries have greatly contributed to our understanding of the relationship between metals and genetics. The fields which have contrib uted to this area range from Clinical Medicine and Genetics to Biochemistry and Chemistry. The aim of this book is to bring together investigators from these diverse fields to reflect on the broad implications of direct and indirect interactions of metals and genetic components. The volume begins with a tribute to the late Karen Wetterhahn, an outstanding scien tist in the field, who will be sadly missed by her friends and colleagues because of her un timely death. The book has 28 chapters contributed by scientists who are internationally known for their expertise and outstanding research. The subject matters are divided into five major sections. The first section discusses genetic response to environmental expo sure to metals. Potentially devastating health crises have been reported in recent years from several parts of the world, which stem from environmental exposure to metals. In this section, authors report their findings on the effects and influence of metals in gene ex pression and their consequences to human health. The section on metal carcinogenesis and metal caused DNA damage, presents the latest advances in our knowledge of the molecu lar mechanisms of metal-induced mutagenesis and carcinogenesis. This topic is at the very heart of our understanding of how cancer may be caused by various metals.




The Prokaryotes


Book Description

The revised Third Edition of The Prokaryotes, acclaimed as a classic reference in the field, offers new and updated articles by experts from around the world on taxa of relevance to medicine, ecology and industry. Entries combine phylogenetic and systematic data with insights into genetics, physiology and application. Existing entries have been revised to incorporate rapid progress and technological innovation. The new edition improves on the lucid presentation, logical layout and abundance of illustrations that readers rely on, adding color illustration throughout. Expanded to seven volumes in its print form, the new edition adds a new, searchable online version.




Advances in Agronomy


Book Description

Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial. Maintains the highest impact factor among serial publications in agriculture Presents timely reviews on important agronomy issues Enjoys a long-standing reputation for excellence in the field




Iron Metabolism


Book Description

Iron plays a crucial role in many biochemical processes. In recent years intensive research has led to a better understanding of the function of iron in cellular metabolism. In more than twenty articles internationally renowned experts give a thorough account of the recent developments of this fascinating field. The book focuses on the central questions, e.g. transport, storage, and utilization of iron in cells, the three-dimensional structure of iron-containing proteins, the physiological function of heme and iron sulfur-containing proteins, and the regulatory mechanisms in heme biosynthesis and redox regulation of signal transduction. The interdisciplinary character of the book is designed to explore the many facets of the new findings and to provide a comprehensive overview of recent advances for biochemists, bioinorganic chemists, molecular biologists, microbiologists and immunologists. The reviews are supplemented with valuable background information, results and numerous references. This book emphasizes the relationships between the different disciplines concerned with iron metabolism and opens new perspectives for future research!




Nitrogen Fixation at the Millennium


Book Description

The turn of the millennium from the twentieth to the twenty-first century provides an occasion to review our understanding of a biological process, biological nitrogen fixation, that is of prime importance for the continued survival of mankind. This process has provided a basis for maintaining soil fertility since the beginning of organised agriculture, yet its very existence was confirmed only just over a century ago. In the intervening years, an enormous intellectual effort has dispersed much of the mystery surrounding biological nitrogen fixation. Biological fixation is widely exploited in agriculture, as are nitrogen fertilisers prepared for the last hundred years under extreme conditions of temperature and pressure. However, despite all our efforts, the fundamental nature of the reactions involved at the heart of the biological process remain unknown. This book aims to describe what we have learned in the last one hundred years or so about biological nitrogen fixation, about what its chemistry appears to be, and how it is applied in agriculture. This ambitious objective has not been attempted recently. It is aimed at students and those who wish to enter these very challenging areas of research, and who need to learn the state of the art at the turn of the millennium.The authors are all acknowledged world experts in their fields. They have prepared concise, well referenced and authoritative accounts of their subjects. This book provides a unique summary of the current state of knowledge that will be indispensable to all students and researchers, actual and potential, interested in biological nitrogen fixation.




Biochemistry of Nickel


Book Description

In this timely monograph, the author summarizes the rapidly growing body of knowledge regarding nickel by providing a balanced discussion of its harmful and beneficial effects. Coverage includes a history of nickel; the chemistry of nickel, descriptions of the four known enzymes which contain nickel; and nickel metabolism in microbes, plants, and animals. Taken as a whole, Dr. Hausinger's work will highlight key features of this important element and help define future research.




New Methods for the Study of Biomolecular Complexes


Book Description

A NATO Advanced Research Workshop entitled New Methods for the Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting was entirely concerned with the problem of analyzing biomolecular complexes, so the title of these proceedings has been altered to give a more precise description of the content. Tbe workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 participants from around the world. '!\venty-one invited talks were given and 27 papers were presented as posters. Of the 48 contributions, 22 papers (12 orals, 10 posters) are included in these proceedings. Tbe subject of the conference was the investigation of noncovalent biomolecular complexes, with particular focus on the application of mass spectrometry to their characterization. '!\vo new ionization techniques introduced in the late 1980s, electrospray ionization (ES I) and matrix-assisted laser desorptionlionization (MALDI), resulted in a breakthrough in mass spectrometry, enabling its use in molecular weight and primary structure determination of biopolymers larger than 100 kDa. Recently it has been discovered that ESI mass spectrometry mayaiso be used to characterize complexes containing noncovalent interactions, thus opening new perspectives for supramolecular chemistry. ESI mass spectrometry has the advantage that the sampie is introduced from a homogenous solution which can be maintained at near physiological conditions of pR, concentration, and temperature.