Regulation of Tissue Oxygenation, Second Edition


Book Description

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.




Phosphate Metabolism


Book Description

We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.




Pulmonary Gas Exchange


Book Description

The lung receives the entire cardiac output from the right heart and must load oxygen onto and unload carbon dioxide from perfusing blood in the correct amounts to meet the metabolic needs of the body. It does so through the process of passive diffusion. Effective diffusion is accomplished by intricate parallel structures of airways and blood vessels designed to bring ventilation and perfusion together in an appropriate ratio in the same place and at the same time. Gas exchange is determined by the ventilation-perfusion ratio in each of the gas exchange units of the lung. In the normal lung ventilation and perfusion are well matched, and the ventilation-perfusion ratio is remarkably uniform among lung units, such that the partial pressure of oxygen in the blood leaving the pulmonary capillaries is less than 10 Torr lower than that in the alveolar space. In disease, the disruption to ventilation-perfusion matching and to diffusional transport may result in inefficient gas exchange and arterial hypoxemia. This volume covers the basics of pulmonary gas exchange, providing a central understanding of the processes involved, the interactions between the components upon which gas exchange depends, and basic equations of the process.




Stewart's Textbook of Acid-Base


Book Description

Rev. ed of: How to understand acid-base. c1981.




Handbook of Blood Gas/Acid-Base Interpretation


Book Description

Handbook of Blood Gas/Acid-Base Interpretation, 2nd edition, simplifies concepts in blood gas/acid base interpretation and explains in an algorithmic fashion the physiological processes for managing respiratory and metabolic disorders. With this handbook, medical students, residents, nurses, and practitioners of respiratory and intensive care will find it possible to quickly grasp the principles underlying respiratory and acid-base physiology, and apply them. Uniquely set out in the form of flow-diagrams/algorithms charts, this handbook introduces concepts in a logically organized sequence and gradually builds upon them. The treatment of the subject in this format, describing processes in logical steps makes it easy for the reader to cover a difficult- and sometimes dreaded- subject rapidly.




Acid-base Balance


Book Description




Renal Physiology


Book Description

Each chapter in this authoritative volume is written by a well-known physiologist who has contributed to our current understanding of renal function. Together the authors offer a unique, inside perspective on the historical record of the discipline, from its roots in the ancient world to the most recent findings of modern times. Among the many topics discussed are renal blood flow and the dynamics of glomerular filtration; the clearance concept in renal physiology; micropuncture and microperfusion; transport of electrolytes across renal tubules; and diuretics and renal drug development.




Critical Care Nephrology E-Book


Book Description

Comprehensive and clinically relevant, the 3rd Edition of Critical Care Nephrology provides authoritative coverage of the latest advances in critical care procedures for patients with renal diseases or disorders. Using common guidelines and standardized approaches to critically ill patients, this multidisciplinary reference facilitates better communication among all physicians who care for critically ill patients suffering from kidney disease, electrolyte and metabolic imbalances, poisoning, severe sepsis, major organ dysfunction, and other pathological events. - Offers detailed discussions of different forms of organ support, artificial organs, infections, acute illness occurring in chronic hemodialysis patients, and much more. - Places a special emphasis on therapeutic interventions and treatment procedures for a hands on clinical reference tool. - Presents information clearly, in a format designed for easy reference – from basic sciences to clinical syndromes to diagnostic tools. - Covers special populations such as children, diabetic patients, and the elderly. - An exceptional resource for nephrologists, intensivists, surgeons, or critical care physicians – anyone who treats critically ill renal patients. - Shares a combined commitment to excellence lead by Drs. Claudio Ronco, Rinaldo Bellomo, John Kellum, and Zaccaria Ricci – unparalleled leaders in this field. - Addresses key topics with expanded coverage of acute kidney injury, stress biomarkers, and sepsis, including the latest developments on mechanisms and management. - Provides up-to-date information on extracorporeal therapies from new editor Dr. Zaccaria Ricci. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.




Therapy of Renal Diseases and Related Disorders


Book Description

A handsome and rugged practical text and ready reference, revised and expanded with 13 new chapters, that blends theory and basic science with practical clinical applications for optimal therapeutic benefit. The 62 contributed chapters are logically organized into eight parts: disorders of fluid, electrolyte, and acid-base balance; intrinsic parenchymal disease; renal involvement in systemic disease; hereditary and congenital diseases; neoplasia; chemical and physical injuries; chronic renal failure; and miscellaneous (i.e. the catheter; and nonsurgical management of vesicourethral dysfunction). Annotation copyrighted by Book News, Inc., Portland, OR