The Metabolist Imagination


Book Description

Japan’s postwar urban imagination through the Metabolism architecture movement and visionary science fiction authors The devastation of the Second World War gave rise to imaginations both utopian and apocalyptic. In Japan, a fascinating confluence of architects and science fiction writers took advantage of this space to begin remaking urban design. In The Metabolist Imagination, William O. Gardner explores the unique Metabolism movement, which allied with science fiction authors to foresee the global cities that would emerge in the postwar era. This first comparative study of postwar Japanese architecture and science fiction builds on the resurgence of interest in Metabolist architecture while establishing new directions for exploration. Gardner focuses on how these innovators created unique versions of shared concepts—including futurity, megastructures, capsules, and cybercities—making lasting contributions that resonate with contemporary conversations around cyberpunk, climate change, anime, and more. The Metabolist Imagination features original documentation of collaborations between giants of postwar Japanese art and architecture, such as the landmark 1970 Osaka Expo. It also provides the most sustained English-language discussion to date of the work of Komatsu Sakyō, considered one of the “big three” authors of postwar Japanese science fiction. These studies are underscored by Gardner’s insightful approach—treating architecture as a form of speculative fiction while positioning science fiction as an intervention into urban design—making it a necessary read for today’s visionaries.




Metabolism in Architecture


Book Description

Even in a country where outstanding achievements have become almost a commonplace, the Japanese architect, Kisho Kurokawa, appears as both a remarkable and a remarkably successful man. With buildings in the United States and Eastern and Western Europe as well as in Japan, he has established an international reputation as a leading figure amongst the younger generation of architects. At the age of forty he already had thirty-five major buildings and seventeen books to his credit; four new towns are being built to his designs; he heads a company of over a hundred employees, he runs a think-tank and an urban design bureau and for variety he has his own television programme with a regular audience of some 30 million. Behind these statistics lies a prodigious vitality expressed in original and stimulating buildings. -- from book jacket.







Project Japan


Book Description

Metabolism was a movement launched in Japan that took inspiration for buildings and cities from biological systems. With interviews and commentary and hundreds of images, Project Japan unearths a history that casts new light on the key issues that both enervate and motivate architecture today.




The Metabolic Pathway Engineering Handbook, Two Volume Set


Book Description

Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab




Pharmacokinetics and Metabolism in Drug Design


Book Description

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.




The Urbanism of Metabolism


Book Description

This edited book explores and promotes reflection on how the lessons of Metabolism experience can inform current debate on city making and future practice in architectural design and urban planning. More than sixty years after the Metabolist manifesto was published, the author’s original contributions highlight the persistent links between present and past that can help to re-imagine new urban futures as well as the design of innovative intra-urban relationships and spaces. The essays are written by experienced scholars and renowned academics from Japan, Australia, Europe, South Korea and the United States and expose Metabolism’s special merits in promoting new urban models and evaluate the current legacy of its architectural projects and urban design lessons. They offer a critical, intellectual, and up-to-date account of the Metabolism projects and ideas with regard to the current evolution of architectural and urbanism discourse in a global context. The collection of cross-disciplinary contributions in this volume will be of great interest to architects, architectural and urban historians, as well as academics, scholars and students in built environment disciplines and Japanese cultural studies.




Metabolism of the Anthroposphere, second edition


Book Description

An overview of the cultural evolution of material flows and stocks with an emphasis on the design of metabolic processes in urban systems. Over the last several thousand years of human life on Earth, agricultural settlements became urban cores, and these regional settlements became tightly connected through infrastructures transporting people, materials, and information. This global network of urban systems, including ecosystems, is the anthroposphere; the physical flows and stocks of matter and energy within it form its metabolism. This book offers an overview of the metabolism of the anthroposphere, with an emphasis on the design of metabolic systems. It takes a cultural historical perspective, supported with methodology from the natural sciences and engineering. The book will be of interest to scholars and practitioners in the fields of regional development, environmental protection, and material management. It will also be a resource for undergraduate and graduate students in industrial ecology, environmental engineering, and resource management. The authors describe the characteristics of material stocks and flows of human settlements in space and time; introduce the method of material flow analysis (MFA) for metabolic studies; analyze regional metabolism and the material systems generated by basic activities; and offer four case studies of optimal metabolic system design: phosphorus management, urban mining, waste management, and mobility. This second edition of an extremely influential book has been substantially revised and greatly expanded. Its new emphasis on design and resource utilization reflects recent debates and scholarship on sustainable development and climate change.




The Metabolic Pathway Engineering Handbook


Book Description

This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction




Drug Metabolism in Drug Design and Development


Book Description

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.