Science and Decisions


Book Description

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.







Public Health Risk Assessment for Human Exposure to Chemicals


Book Description

In fact, with the control and containment of most infectious conditions and diseases of the past millennium having been achieved in most developed countries, and with the resultant increase in life expectancies, much more attention seems to have shifted to degenerative health problems. Many of the degenerative health conditions have been linked to thousands of chemicals regularly encountered in human living and occupational/work environments. It is important, therefore, that human health risk assessments are undertaken on a consistent basis - in order to determine the potential impacts of the target chemicals on public health.




A Practical Guide to Toxicology and Human Health Risk Assessment


Book Description

Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.




Science and Judgment in Risk Assessment


Book Description

The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.




Air Toxics Risk Assessment Reference Library


Book Description

This technical resource document describes several methods for preparing a site-specific risk assessment for a source (i.e., a single emission point within one facility), a group of sources (i.e., multiple emission points within one facility), or a group of similar facilities (e.g., within the same source category) that emit(s) toxic air pollutants. Air toxics may be emitted from power plants, factories, cars and trucks, and common household products. Sources that stay in one place are referred to as stationary sources. Vehicles and other moving sources of air pollutants are called mobile sources. This technical resource document is intended for assessing risks associated with stationary sources of air toxics. While its primary focus is on Hazardous Air Pollutants (HAPs), this resource document can be applied to all air pollutants (with the exception of criteria air pollutants, which are assessed using different tools and methods). This technical resource document is the second of a three-volume set. Volume 1: Technical Resource Manual discusses the overall air toxics risk assessment process and the basic technical tools needed to perform these analyses. The manual addresses both human health and ecological analyses. It also provides a basic overview of the process of managing and communicating risk assessment results. Other evaluations (such as the public health assessment process) are described to give assessors, risk managers, and other stakeholders a more holistic understanding of the many issues that may come into play when evaluating the potential impact of air toxics on human health and the environment. Readers with a limited understanding of risk assessment are encouraged to consult Volume 1. Volume 2: Facility-Specific Assessment (this volume) builds on the technical tools described in Volume 1 by providing an example set of tools and procedures that can be used for source-specific or facility-specific risk assessments. Information is also provided on tiered approaches to source- or facility-specific risk analysis. Volume 3: Community-Level Assessment builds on the information presented in Volume 1 to describe to communities how they can evaluate and reduce air toxics risks at the local level. The volume will include information on screening level and more detailed analytical approaches, how to balance the need for assessment versus the need for action, and how to identify and prioritize risk reduction options and measure success. Since community concerns and issues are often not related solely to air toxics, the document will also present readily available information on additional multimedia risk factors that may affect communities and strategies to reduce those risks. The document will provide additional, focused information on stakeholder involvement, communicating information in a community-based setting, and resources and methodologies that may play a role in the overall process. Note that EPA's Office of Pollution Prevention and Toxics has also developed a Community Air Screening How To Manual that will be available in 2004 and will be discussed in Volume 3.




Risk Assessment for Environmental Health


Book Description

Written by experts in the field, this important book provides anintroduction to current risk assessment practices and proceduresand explores the intrinsic complexities, challenges, andcontroversies associated with analysis of environmental healthrisks. Environmental Health Risk Assessment for Public Healthoffers 27 substantial chapters on risk-related topics thatinclude: What Is Risk and Why Study Risk Assessment The Risk Assessment–Risk Management Paradigm Risk Assessment and Regulatory Decision-Making in EnvironmentalHealth Toxicological Basis of Risk Assessment The Application of PBPK Modeling to Risk Assessment Probabilistic Models to Characterize Aggregate and CumulativeRisk Molecular Basis of Risk Assessment Comparative Risk Assessment Occupational Risk Radiological Risk Assessment Microbial Risk Assessment Children’s Risk Assessment Life Cycle Risk Environmental Laws and Regulations Precautionary Principles Risk Communication




Toxicity-Pathway-Based Risk Assessment


Book Description

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.




Calculated Risks


Book Description

Safeguarding economic prosperity, whilst protecting human health and the environment, is at the forefront of scientific and public interest. This book provides a practical and balanced view on toxicology, control, risk assessment and risk management, addressing the interplay between science and public health policy. This revised edition provides a detailed analysis on chemical and by-product exposure, how they enter the body and the suitability of imposed safety limits. Chapters on dose, with particular emphasis on children and vulnerable subpopulations, reproductive and developmental toxicants and toxicity testing are included. With updated and comprehensive coverage of international developments of risk management and safety, this will have broad appeal to researchers and professionals involved in chemical safety and regulation as well as the general reader interested in environmental pollution and public health.




Risk Assessment of Chemicals: An Introduction


Book Description

In recent years many developments have taken place in promote co-operation between governments and other the field of risk assessment of chemicals. Many reports parties involved in chemical safety and to provide policy have been published by national authorities, industries guidance with emphasis on regional and subregional co and scientific researchers as well as by international bod operation. The Inter-Organization Programme for the ies such as the European Union, the Organization of Sound Management of Chemicals (IOMC) was estab Economic Cooperation and Development (OECD) and lished in 1995 and provides a mechanism for the six par the joint International Programme on Chemical Safety ticipating organizations (UNEP, ILO, FAO, UNIDO,WHO (IPCS) of the World Health Organization (WHO), the and OECD) to better co-ordinate policies and activities in International Labour Organization (lLO), and the United the field of chemical risk management. Nations Environment Programme (UNEP). The present book is an introduction to risk assessment of The development and international harmonization of risk chemicals. It contains basic background information on assessment methods is an important challenge. In sources, emissions, distribution and fate processes for Agenda 21 of the United Nations Conference on exposure estimation. It includes dose-effects estimation Environment and Development (UNCED), chapter 19 is for both human health related toxicology and ecotoxicol entirely devoted to the management of chemicals. For ogy as well as information on estimation methodologies. one of its recommendations, i. e.