Model Organisms to Study Biological Activities and Toxicity of Nanoparticles


Book Description

This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.




Green Plant Extract-Based Synthesis of Multifunctional Nanoparticles and their Biological Activities


Book Description

The convergence of nanotechnology with agriculture has transformed farming, while also impacting medicine, biotechnology and environmental science. Plant extracts isolated using new technologies have been used to successfully create new medicines for specific diseases. This book focuses on the eco-friendly synthesis of plant extracts. It provides information about multifunctional nanoparticles, and their versatile applications, including agriculture, food safety, and environmental remediation. The book aims to bridge the gap between nanotechnology and public perception, addressing concerns related to health and environmental impact. Themes within the book span across green synthesis techniques for noble metal nanoparticles, the crucial role of analytical methods in characterizing these "green nanomaterials," and the comprehensive examination of how nanoparticles interact with the human body. Furthermore, the intricate relationships between proteins and nanoparticles is highlighted to explain the physicochemical effects and toxicity of nanomaterials. Readers will learn about sustainable and environmentally friendly approaches for synthesizing nanoparticles, while getting a glimpse of the promising future of nanotechnology in agriculture and beyond.




Silver Nanoparticles


Book Description

Silver nanoparticles are the subject of immense interest because of their distinct chemical and physical properties that are different from their bulk counterpart. This makes these nanoparticles very important in many fields including antimicrobial applications, biosensor materials, composite fibers, cryogenic superconducting materials, cosmetic products, and electronic components. This book aims to provide in-depth study and analysis of various fabrication, characterization, and application techniques of silver nanoparticles that lead these nanoparticles very important in the recent technology. This book presents deep understanding of the new techniques from basic to the advanced level. This book addresses scientists, engineers, doctoral and postdoctoral fellows, and technical professionals working in specialized fields.




Engineered Nanoparticles and the Environment


Book Description

Details the source, release, exposure, adsorption, aggregation, bioavailability, transport, transformation, and modeling of engineered nanoparticles found in many common products and applications Covers synthesis, environmental application, detection, and characterization of engineered nanoparticles Details the toxicity and risk assessment of engineered nanoparticles Includes topics on the transport, transformation, and modeling of engineered nanoparticles Presents the latest developments and knowledge of engineered nanoparticles Written by world leading experts from prestigious universities and companies




Computational Nanotoxicology


Book Description

The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials (ENMs) has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of ENMs, computational methods originally developed for regular chemicals cannot always be applied explicitly in nanotoxicology. This book discusses the current state of the art and future needs in the development of computational modeling techniques for nanotoxicology. It focuses on (i) computational chemistry (quantum mechanics, semi-empirical methods, density functional theory, molecular mechanics, molecular dynamics), (ii) nanochemoinformatic methods (quantitative structure–activity relationship modeling, grouping, read-across), and (iii) nanobioinformatic methods (genomics, transcriptomics, proteomics, metabolomics). It reviews methods of calculating molecular descriptors sufficient to characterize the structure of nanoparticles, specifies recent trends in the validation of computational methods, and discusses ways to cope with the uncertainty of predictions. In addition, it highlights the status quo and further challenges in the application of computational methods in regulation (e.g., REACH, OECD) and in industry for product development and optimization and the future directions for increasing acceptance of computational modeling for nanotoxicology.




Nanomaterials for Sustainable Development


Book Description

This book highlights recent advances in variety of nanomaterials classes including metal chalcogenides, metal oxides/hydroxides, polymer, metal-organic frameworks, and hybrid nanostructures, with a focus on their properties, synthesis methods, and key applications. It also offers detailed coverage on the toxicity aspects with possible solution. Additionally, it provides complete and comprehensive information on surface modification strategies of nanoparticles to achieve desired outcomes. This book discusses potential applications and major challenges of using these nanomaterials in the fields of biomedical sciences, agricultural industry, bioenergy, biofuel production, and environmental remediation, etc. Overall, this book provides crucial background in nanobiotechnology that compliments the understanding of experimental design for the production of more customized nanomaterials to avail desirable benefits.




Emerging Nanomaterials and Their Impact on Society in the 21st Century


Book Description

The book covers the synthesis, classification, characterization, applications and historical background of nanomaterials in various sectors, such as nanosensors, healthcare, solar cells, energy storage, hydrogels, nanocatalysts, sport industry, automobile sector, construction industry, lubricant industry, defense and security, textiles, food sciences, agriculture and biomedical applications. Keywords: Carbon Nanomaterials , Functionalized Carbon Nanomaterials, Smart Nanomaterials, Hybrid Nanomaterials, Biomedical Applications, Drug Delivery, Soy Protein Isolate, Healthcare, Perovskite Solar Cells, Nanoemulsions, Lubricant Industry, Binding Materials, Construction Industry, Toxicological Effects, Aquatic Biota, Safety Concerns.




The ELSI Handbook of Nanotechnology


Book Description

This Handbook focuses on the recent advancements in Safety, Risk, Ethical Society and Legal Implications (ESLI) as well as its commercialization of nanotechnology, such as manufacturing. Nano is moving out of its relaxation phase of scientific route, and as new products go to market, organizations all over the world, as well as the general public, are discussing the environmental and health issues associated with nanotechnology. Nongovernmental science organizations have long since reacted; however, now the social sciences have begun to study the cultural portent of nanotechnology. Societal concerns and their newly constructed concepts, show nanoscience interconnected with the economy, ecology, health, and governance. This handbook addresses these new challenges and is divided into 7 sections: Nanomaterials and the Environment; Life Cycle Environmental Implications of Nanomanufacturing; Bioavailability and Toxicity of Manufactured Nanoparticles in Terrestrial Environments; Occupational Health Hazards of Nanoparticles; Ethical Issues in Nanotechnology; Commercialization of Nanotechnology; Legalization of Nanotechnology.




Copper Nanostructures: Next-Generation of Agrochemicals for Sustainable Agroecosystems


Book Description

Copper Nanostructures: Next-Generation of Agrochemicals for Sustainable Agroecosystems considers the impact of copper-based nanostructures on agri-food sectors. Sections highlight the green synthesis of copper nanoparticles, production mechanisms, eco-safety, and future perspectives, discuss the increasing importance of copper nanomaterials in plant protection applications, describe the use of copper nanostructures in plant science applications, cover antimicrobial applications, explore copper nanostructure applications, and summarize current applications in agroecosystems, such as copper nanoparticles as nanosensors, their negative ecological effects, estimation risks, and more. - Assesses the impact of a large variety of copper-based nanostructures on the agri-food sector - Discusses how the properties of a variety of copper-based nanomaterials make them effective for agricultural applications - Explains the challenges surrounding the mass production of copper-based nanomaterials