Author : Kaushik Parthasarathi
Publisher : Springer
Page : 90 pages
File Size : 31,21 MB
Release : 2017-12-29
Category : Medical
ISBN : 3319684833
This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
Author : Toshio Nakanishi
Publisher : Springer Nature
Page : 374 pages
File Size : 18,89 MB
Release : 2020-02-28
Category : Medical
ISBN : 9811511853
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Author : N. Radhakrishnan
Publisher : Academic Press
Page : 520 pages
File Size : 32,60 MB
Release : 2022-01-04
Category : Science
ISBN : 0323884342
Genesis, Pathophysiology Management of Venous Diseases is the must-have resource on venous disease. The book bridges the gap between basic science and clinical medicine, covering the history of venous surgery, the lymphatic system and anatomy, pathophysiology of various venous disease, etiology, clinical manifestations and diagnosis, management, and medical and surgical treatment options. It also places attention on genetic studies and pharmacological analysis of various anticoagulants which are widely used in treating venous diseases and deep vein thrombosis and highlights the importance of microscopic venous valves and their pathology in both normal and disease condition. The breadth of topics covered makes this reference suitable for a range of professionals in phlebolymphology and cardiology, including medical students, practicing clinicians, surgeons, researchers, radiologists, bioengineers, and more. Provides complete, up-to-date developments in the field of phlebolymphology, including the history of venous surgery, lymphatic system and anatomy, pathophysiology of various venous disease, and more Includes new etiological and pathophysiological concepts and the latest outlooks and trends in the management of CVD Written in an easy-to-read manner, the book includes tables, figures, clinical photographs and medical illustrations to aid understanding
Author : Alan H. Jobe
Publisher : Cambridge University Press
Page : pages
File Size : 12,77 MB
Release : 2016-04-18
Category : Medical
ISBN : 1316665178
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 48,23 MB
Release : 2010
Category : Government publications
ISBN :
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Jason X. -J. Yuan
Publisher : Springer Science & Business Media
Page : 1640 pages
File Size : 47,8 MB
Release : 2011-03-24
Category : Medical
ISBN : 0387874291
Textbook of Pulmonary Vascular Diseases combines basic scientific knowledge on the pulmonary circulatory system at levels of the molecule, cell, tissue, and organ with clinical diagnosis and treatment of pulmonary vascular diseases. State-of-the-art techniques and their potential applications in research, diagnosis, and treatment of pulmonary vascular diseases are also covered.
Author : Julia Polak
Publisher : World Scientific
Page : 529 pages
File Size : 10,91 MB
Release : 2010
Category : Medical
ISBN : 1848164408
"The use of stem cells to help with lung regeneration and repair is a novel therapy which could help phase out the need for conventional surgical or pharmacological approaches currently employed to treat diseases of the lung or other organs. The present book explores all avenues of this new form of medical care, moving swiftly, but in depth, from the basic science of lung development, to the analyses of different stem cell types available for regeneration and on to the application of this knowledge base in initial clinical trials. In this volume a stellar group of researchers converge, from different angles, to help towards clarifying the basic mechanisms of lung repair. These range from basic concepts of regeneration and lung development, the analyses of a variety of cell types that may be involved in lung repair, to ways of creating complex lung structures, including artificial and bioartificial lungs. The book offers an insight into repair mechanisms of the diseased lung, the role of specific lung niches and provides information on initial clinical trials as well as the use of stem cells as vehicles for gene therapy. Ingenious technological aspects of assessing stem cell engraftment of stem cell bioprocessing are also included in this volume."--Publisher's website.
Author : Christoph Thiemermann
Publisher : Frontiers Media SA
Page : 268 pages
File Size : 12,44 MB
Release : 2024-07-24
Category : Medical
ISBN : 2832552072
Life-threatening organ dysfunction/failure in critically ill patients suffering from sepsis or trauma is caused by a dysregulated host response to infection and/or inflammation. Despite significant advances in our understanding of some of the key signaling pathways involved in the excessive inflammation associated with sepsis/trauma, the translation of our current understanding of the underlying pathophysiology into organ-protective therapeutic strategies is still very limited. Current therapeutic approaches, hence, continue to rely on source control, antibiotics and supportive care, and particularly early goal-directed therapy.
Author :
Publisher : Academic Press
Page : 294 pages
File Size : 22,71 MB
Release : 2018-10-22
Category : Science
ISBN : 0128158077
Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial Glycocalyx, Cholesterol Regulation of Endothelial Cell Calcium Homeostasis in Pulmonary Hypertension, Mechanosensitive Channels and Gap Junction Channels in EC, Endothelial Protrusions in Junctional Integrity and Barrier Function, Cortical Actin Dynamics in Endothelial Permeability, Endothelial Microparticles and Exosomes, Store Operated TRP Channels and Endothelial Responses, and Caveolin and Endothelial NO signaling. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Membranes series - Includes the latest information on Membranes in Pulmonary Vascular Disease
Author : John N. Maina
Publisher : Springer Nature
Page : 391 pages
File Size : 27,1 MB
Release : 2023-09-13
Category : Science
ISBN : 3031351800
Birds have and continue to fascinate scientists and the general public. While the avian respiratory system has unremittingly been investigated for nearly five centuries, important aspects on its biology remain cryptic and controversial. In this book, resolving some of the contentious issues, developmental-, structural- and functional aspects of the avian lung-air sac system are particularized: it endeavors to answer following fundamental questions on the biology of birds: how, when and why did birds become what they are? Flight is a unique form of locomotion. It considerably shaped the form and the essence of birds as animals. An exceptionally efficient respiratory system capacitated birds to procure the exceptionally large quantities of oxygen needed for powered (active) flight. Among the extant air-breathing vertebrates, comprising ~11,000 species, birds are the most species-rich-, numerically abundant- and extensively distributed animal taxon. After realizing volancy, they easily overcame geographical obstacles and extensively dispersed into various ecological niches where they underwent remarkable adaptive radiation. While the external morphology of birds is inconceivably uniform for such a considerably speciose taxon, contingent on among other attributes, lifestyle, habitat and phylogenetic level of development have foremost determined the novelties that are displayed by diverse species of birds. Here, critical synthesizes of the most recent findings with the historical ones, evolution and behavior and development, structure and function of the exceptionally elaborate respiratory system of birds are detailed. The prominence of modern birds as a taxon in the Animal Kingdom is underscored. The book should appeal to researchers who are interested in evolutionary processes and how adaptive specializations correlate with biological physiognomies and exigencies, comparative biologists who focus on how various animals have solved respiratory pressures, people who study respiration in birds and other animals and ornithologists who love and enjoy birds for what they are – profoundly interesting animals.
