Molecular Basis for Genetic Instability in Werner Syndrome
Author : Polly Rodgers Prince
Publisher :
Page : 212 pages
File Size : 18,98 MB
Release : 1999
Category :
ISBN :
Author : Polly Rodgers Prince
Publisher :
Page : 212 pages
File Size : 18,98 MB
Release : 1999
Category :
ISBN :
Author : Michel Lebel
Publisher : Springer Science & Business Media
Page : 172 pages
File Size : 48,32 MB
Release : 2004-09-14
Category : Medical
ISBN : 9780306482335
During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
Author : Jean-Nicolas Volff
Publisher : Karger Medical and Scientific Publishers
Page : 255 pages
File Size : 22,10 MB
Release : 2006-01-01
Category : Medical
ISBN : 3805580290
Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important 'caretaker' genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.
Author : P. Michael Conn
Publisher : Elsevier
Page : 1103 pages
File Size : 10,14 MB
Release : 2011-04-28
Category : Medical
ISBN : 0080460062
The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations
Author : Michel Lebel
Publisher :
Page : pages
File Size : 14,42 MB
Release : 2003
Category :
ISBN : 9781587062155
Author :
Publisher : Academic Press
Page : 417 pages
File Size : 43,14 MB
Release : 2010-12-17
Category : Science
ISBN : 0080962033
A number of genes have been identified that are associated with an increased body mass index (BMI), the standard measurement of obesity. By analyzing these genes, researchers hope to gain a better understanding of what causes obesity and develop ways to tackle the problem. The study of genes and obesity could lead to new treatments. Genes and Obesity reviews the latest developments in the field. - This series provides a forum for discussion of new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
Author : Fuki Hisama
Publisher : CRC Press
Page : 598 pages
File Size : 35,11 MB
Release : 2003-01-29
Category : Medical
ISBN : 0824708563
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.
Author : Arthur Robert Peacocke
Publisher :
Page : 198 pages
File Size : 43,75 MB
Release : 1965
Category : Biochemical genetics
ISBN :
Genetik, Genetik und Evolutionsforschung.
Author : Juan Carlos Gomez-Verjan
Publisher : Springer Nature
Page : 274 pages
File Size : 16,48 MB
Release : 2020-04-13
Category : Medical
ISBN : 3030409554
The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.
Author : Julien Bogousslavsky
Publisher : Cambridge University Press
Page : 418 pages
File Size : 36,13 MB
Release : 2001-05-24
Category : Medical
ISBN : 9780521771450
An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.