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Molecular Biology of RGS Proteins

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Publisher : Academic Press

Page : 389 pages

File Size : 24,60 MB

Release : 2009-07-21

Category : Science

ISBN : 0080911978

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Book Description

Molecular Biology of RGS Proteins, a volume of Progress in Molecular Biology and Translational Science, will include historical discussion of RGS proteins, the role of RGS proteins in addiction, depression and Parkinson's disease and the biology and functional regulation of RGS9 isoforms. This publication further discusses RGS proteins in cellular signaling, protein control in lymphocyte function, and alternative splicing of RGS transcripts and nuclear RGS proteins, offering the latest in research of RGS proteins.



RGS Protein Physiology and Pathophysiology

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Publisher : Academic Press

Page : 243 pages

File Size : 36,17 MB

Release : 2015-06-23

Category : Science

ISBN : 0128029544

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Book Description

RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery



Molecular Biology of RGS Proteins

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Publisher : Academic Press

Page : 400 pages

File Size : 18,98 MB

Release : 2009-08-07

Category : Science

ISBN : 9780123747594

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Book Description

Molecular Biology of RGS Proteins, a volume of Progress in Molecular Biology and Translational Science, will include historical discussion of RGS proteins, the role of RGS proteins in addiction, depression and Parkinson's disease and the biology and functional regulation of RGS9 isoforms. This publication further discusses RGS proteins in cellular signaling, protein control in lymphocyte function, and alternative splicing of RGS transcripts and nuclear RGS proteins, offering the latest in research of RGS proteins.



G Protein Signaling

Author : Alan V. Smrcka

Publisher : Humana Press

Page : 250 pages

File Size : 12,44 MB

Release : 2003-09-15

Category : Science

ISBN : 9781588291370

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Book Description

A collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible techniques presented are those for the purification of G proteins and effectors enzymes, assays of these purified G proteins and effector enzymes, and for the study of G proteins interactions with effectors in intact cells. Additional methods are provided for assaying G protein coupled receptor structure, function, and localization; for studying the physiological roles for endogenous G proteins; and for examining lipid and phosphate modifications of RGS proteins.



Regulators of G Protein Signaling, Part A

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Publisher : Elsevier

Page : 475 pages

File Size : 19,41 MB

Release : 2004-11-25

Category : Science

ISBN : 0080497268

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Book Description

Regulators of G Protein Signaling, Part A is an in-depth treatment of G-Protein Signaling, and will cover general methods of analysis of RGS protein analysis, including Expression and post-translational modification, Assays of GAP activity and allosteric control, Electrophysiological methods and RGS-insensitive Ga subunits, Mouse models of RGS protein action, Methods of RGS protein inhibition, and G-protein regulators of model organisms. Table of Contents Expression and post-translational modification Assays of GAP activity and allosteric control Electrophysiological methods and RGS-insenstitive Ga subunits Mouse Models of RGS protein action Methods of RGS protein inhibition G-protein regulators of model organisms



G Protein Signaling

Author : Alan V. Smrcka

Publisher : Humana Press

Page : 250 pages

File Size : 37,91 MB

Release : 2003-09-15

Category : Science

ISBN : 9781588291370

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Book Description

A collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible techniques presented are those for the purification of G proteins and effectors enzymes, assays of these purified G proteins and effector enzymes, and for the study of G proteins interactions with effectors in intact cells. Additional methods are provided for assaying G protein coupled receptor structure, function, and localization; for studying the physiological roles for endogenous G proteins; and for examining lipid and phosphate modifications of RGS proteins.



G Protein Pathways, Part B: G Proteins and Their Regulators

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Publisher : Elsevier

Page : 813 pages

File Size : 20,16 MB

Release : 2001-12-18

Category : Science

ISBN : 008049692X

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Book Description

This volume covers topics such as the structure and identification of functional domains of G proteins, and activation of G proteins by receptors or other regulators. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences.



G Protein-Coupled Receptors - Part A

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Publisher : Elsevier

Page : 230 pages

File Size : 22,98 MB

Release : 2022-12

Category : Science

ISBN : 0323994318

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Book Description

G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs



Regulators of G Protein Signaling, Part B

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Publisher : Elsevier

Page : 555 pages

File Size : 24,62 MB

Release : 2004-11-16

Category : Science

ISBN : 0080497276

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Book Description

Regulators of G Protein Signaling, Part B continues the in-depth treatment of the topic and covers the RSG protein superfamily including RZ, R4, R7, R12, RhoGEF, and GRK, as well as other heterotrimeric G-protein signaling regulators. Table of Contents RZ Subfamily R4 Subfamily R7 Subfamily R12 Subfamily RhoGEF Subfamily GRK Subfamily Other RGS proteins Activators Inhibitors Other Modulators



Encyclopedia of Signaling Molecules

Author : Sangdun Choi

Publisher : Springer

Page : 6330 pages

File Size : 17,72 MB

Release : 2017-12-15

Category : Medical

ISBN : 9781493968008

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Book Description

The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.