Mt1-Mmp Regulates Central Nervous System Development Through Notch Signaling
Author : Jin Zhou
Publisher :
Page : pages
File Size : 31,57 MB
Release : 2017-01-26
Category :
ISBN : 9781361031896
Author : Jin Zhou
Publisher :
Page : pages
File Size : 31,57 MB
Release : 2017-01-26
Category :
ISBN : 9781361031896
Author : 周瑾
Publisher :
Page : 432 pages
File Size : 42,19 MB
Release : 2012
Category : Cellular signal transduction
ISBN :
Author : Jin Zhou (Ph. D.)
Publisher :
Page : 432 pages
File Size : 28,43 MB
Release : 2012
Category : Cellular signal transduction
ISBN :
Author : Guoxiang Jin
Publisher : Open Dissertation Press
Page : pages
File Size : 12,76 MB
Release : 2017-01-26
Category :
ISBN : 9781361239148
This dissertation, "MT1-MMP Regulates Early Lymphocyte Development Through Notch Signaling" by Guoxiang, Jin, 金国祥, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4401344 Subjects: Metalloproteinases Lymphocytes - Physiology
Author : Guoxiang Jin
Publisher :
Page : 410 pages
File Size : 15,68 MB
Release : 2009
Category : Lymphocytes
ISBN :
Author : Neil J. Clendeninn
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 37,70 MB
Release : 2000-09-17
Category : Medical
ISBN : 159259011X
Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.
Author : Robert P. Erickson
Publisher : Oxford University Press
Page : 1553 pages
File Size : 31,59 MB
Release : 2016
Category : Medical
ISBN : 0199934525
Preceded by: Inborn errors of development / edited by Charles J. Epstein, Robert P. Erickson, Anthony Wynshaw-Boris. 2nd ed. 2008.
Author : William C. Parks
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 20,24 MB
Release : 2011-04-07
Category : Science
ISBN : 3642168612
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Author : J. F. Woessner
Publisher :
Page : 0 pages
File Size : 47,51 MB
Release : 2023
Category : Extracellular matrix proteins
ISBN : 9781383020427
This study covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of identified MMPs.
Author : Robert Clarke
Publisher : Springer
Page : 220 pages
File Size : 43,61 MB
Release : 2019-03-01
Category : Medical
ISBN : 303005067X
This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.