Multimodal Image Registration Using Multivariate Information Theoretic Similarity Measures


Book Description

Multimodal and multiprotocol image registration refers to the process of alignment of two or more images obtained from different imaging modalities (e.g. digitized histology and MRI) and protocols (e.g. T2-w and PD-w MRI). Registration is a critical component in medical applications including image guided surgery, image fusion for cancer diagnosis and treatment planning, and automated tissue annotation. However, registration is often complicated on account of differences in both the image intensities and the shape of the underlying anatomy. For example, non-linear differences in the overall shape of the prostate between in vivo MRI and ex vivo whole mount histology (WMH) often exist as a result of the presence of an endorectal coil during pre-operative MR imaging and deformations to the specimen during slide preparation. To overcome these challenges, we present new registration techniques termed Combined Feature Ensemble Mutual Information (COFEMI) and Collection of Image-derived Non-linear Attributes for Registration Using Splines (COLLINARUS). The goal COFEMI is to provide a similarity measure that is driven by unique low level textural features, for registration that is more robust to intensity artifacts and modality differences than measures restricted to intensities alone. COLLINARUS offers the robustness of COFEMI to artifacts and modality differences, while allowing fully automated non-linear image warping at multiple scales via a hierarchical B-spline mesh grid. In addition, since routine clinical imaging procedures often involve the acquisition of multiple imaging protocols, we present a technique termed Multi-attribute Combined Mutual Information (MACAMI) to leverage the availability of multiple image sets to improve registration. We apply our registration techniques to a unique clinical dataset comprising 150 sets of in vivo MRI and post-operative WMH images from 25 patient studies in order to retrospectively establish the spatial extent of prostate cancer (CaP) on structural (T2-w) and functional (DCE) in vivo MRI. Accurate mapping of CaP on MRI is used to facilitate the development and evaluation of a system for computer-assisted detection (CAD) of CaP on multiprotocol MRI. We also demonstrate our registration and CAD algorithms in developing radiation therapy treatment plans that provide dose escalation to CaP by elastically registering diagnostic MRI with planning CT.







Mutual Information Based Methods to Localize Image Registration [electronic Resource]


Book Description

Modern medicine has become reliant on medical imaging. Multiple modalities, e.g. magnetic resonance imaging (MRI), computed tomography (CT), etc., are used to provide as much information about the patient as possible. The problem of geometrically aligning the resulting images is called image registration. Mutual information, an information theoretic similarity measure, allows for automated intermodal image registration algorithms. In applications such as cancer therapy, diagnosticians are more concerned with the alignment of images over a region of interest such as a cancerous lesion, than over an entire image set. Attempts to register only the regions of interest, defined manually by diagnosticians, fail due to inaccurate mutual information estimation over the region of overlap of these small regions. This thesis examines the region of union as an alternative to the region of overlap. We demonstrate that the region of union improves the accuracy and reliability of mutual information estimation over small regions. We also present two new mutual information based similarity measures which allow for localized image registration by combining local and global image information. The new similarity measures are based on convex combinations of the information contained in the regions of interest and the information contained in the global images. Preliminary results indicate that the proposed similarity measures are capable of localizing image registration. Experiments using medical images from computer tomography and positron emission tomography demonstrate the initial success of these measures. Finally, in other applications, auto-detection of regions of interest may prove useful and would allow for fully automated localized image registration. We examine methods to automatically detect potential regions of interest based on local activity level and present some encouraging results.




COMPSTAT 2006 - Proceedings in Computational Statistics


Book Description

International Association for Statistical Computing The International Association for Statistical Computing (IASC) is a Section of the International Statistical Institute. The objectives of the Association are to foster world-wide interest in e?ective statistical computing and to - change technical knowledge through international contacts and meetings - tween statisticians, computing professionals, organizations, institutions, g- ernments and the general public. The IASC organises its own Conferences, IASC World Conferences, and COMPSTAT in Europe. The 17th Conference of ERS-IASC, the biennial meeting of European - gional Section of the IASC was held in Rome August 28 - September 1, 2006. This conference took place in Rome exactly 20 years after the 7th COMP- STAT symposium which was held in Rome, in 1986. Previous COMPSTAT conferences were held in: Vienna (Austria, 1974); West-Berlin (Germany, 1976); Leiden (The Netherlands, 1978); Edimbourgh (UK, 1980); Toulouse (France, 1982); Prague (Czechoslovakia, 1984); Rome (Italy, 1986); Copenhagen (Denmark, 1988); Dubrovnik (Yugoslavia, 1990); Neuchˆ atel (Switzerland, 1992); Vienna (Austria,1994); Barcelona (Spain, 1996);Bristol(UK,1998);Utrecht(TheNetherlands,2000);Berlin(Germany, 2002); Prague (Czech Republic, 2004).




New Information Theoretic Distance Measures and Algorithms for Multimodality Image Registration


Book Description

We perform the unbiased affine registration of 5 multimodality images of anatomy, CT, MR PD, T1 and T2 from Visible Human Male Data and the unbiased nonrigid registration of three MR 3D images of the brain with the normalized metric and high-dimensional histogramming . Our results demonstrate the efficacy of the metrics and high-dimensional histogramming in affine and nonrigid multimodality image registration.










Image Registration Based on Point Similarity Measures


Book Description

Image Registration is an important tool for medical image analysis. It can be used to find complex spatial relationship between images even in the case of multi-modality data. Point similarity measures were shown to provide several benefits to the registration process. Although they are intensity-based, they enable multi-modality assessment of the most localized image discrepancies by measuring similarity of arbitrary small image subregions, including individual image points. Such local properties enable registration process to avoid interpolation artifacts commonly observed using other intensity-based similarity measures. Furthermore, point similarity measures separate the registration process into functionally independent parts of similarity measurement, optimization and spatial regularization, simplifying design and testing of registration methods. Finally, they enable straightforward integration of additional knowledge of the problem domain, and thus enable additional registration improvements.




Medical Image Registration


Book Description

Image registration is the process of systematically placing separate images in a common frame of reference so that the information they contain can be optimally integrated or compared. This is becoming the central tool for image analysis, understanding, and visualization in both medical and scientific applications. Medical Image Registration provid




Image Information Distance Analysis and Applications


Book Description

Image similarity or distortion assessment is fundamental to a broad range of applications throughout the field of image processing and machine vision. These include image restoration, denoising, coding, communication, interpolation, registration, fusion, classification and retrieval, as well as object detection, recognition, and tracking. Many existing image similarity measures have been proposed to work with specific types of image distortions (e.g., JPEG compression). There are also methods such as the structural similarity (SSIM) index that are applicable to a wider range of applications. However, even these "general-purpose" methods offer limited scopes in their applications. For example, SSIM does not apply or work properly when significant geometric changes exist between the two images being compared. The theory of Kolmogorov complexity provides solid groundwork for a generic information distance metric between any objects that minorizes all metrics in the class. The Normalized Information Distance (NID) metric provides a more useful framework. While appealing, the challenge lies in the implementation, mainly due to the non-computable nature of Kolmogorov complexity. To overcome this, a Normalized Compression Distance (NCD) measure was proposed, which is an effective approximation of NID and has found successful applications in the fields of bioinformatics, pattern recognition, and natural language processing. Nevertheless, the application of NID for image similarity and distortion analysis is still in its early stage. Several authors have applied the NID framework and the NCD algorithm to image clustering, image distinguishability, content-based image retrieval and video classification problems, but most reporting only moderate success. Moreover, due to their focuses on ! specific applications, the generic property of NID was not fully exploited. In this work, we aim for developing practical solutions for image distortion analysis based on the information distance framework. In particular, we propose two practical approaches to approximate NID for image similarity and distortion analysis. In the first approach, the shortest program that converts one image to another is found from a list of available transformations and a generic image similarity measure is built on computing the length of this shortest program as an approximation of the conditional Kolmogorov complexity in NID. In the second method, the complexity of the objects is approximated using Shannon entropy. Specifically we transform the reference and distorted images into wavelet domain and assume local independence among image subbands. Inspired by the Visual Information Fidelity (VIF) approach, the Gaussian Scale Mixture (GSM) model is adopted for Natural Scene Statistics (NSS) of the images to simplify the entropy computation. When applying image information distance framework in real-world applications, we find information distance measures often lead to useful features in many image processing applications. In particular, we develop a photo retouching distortion measure based on training a Gaussian kernel Support Vector Regression (SVR) model using information theoretic features extracted from a database of original and edited images. It is shown that the proposed measure is well correlated with subjective ranking of the images. Moreover, we propose a tone mapping operator parameter selection scheme for High Dynamic Range (HDR) images. The scheme attempts to find tone mapping parameters that minimize the NID of the HDR image and the resulting Low Dynamic Range (LDR) image, and thereby minimize the information loss in HDR to LDR tone mapping. The resulting images created by minimizing NID exhibit enhanced image quality.