Mutational and Morphological Analysis


Book Description

The analysis, processing, evolution, optimization and/or regulation, and control of shapes and images appear naturally in engineering (shape optimization, image processing, visual control), numerical analysis (interval analysis), physics (front propagation), biological morphogenesis, population dynamics (migrations), and dynamic economic theory. These problems are currently studied with tools forged out of differential geometry and functional analysis, thus requiring shapes and images to be smooth. However, shapes and images are basically sets, most often not smooth. J.-P. Aubin thus constructs another vision, where shapes and images are just any compact set. Hence their evolution -- which requires a kind of differential calculus -- must be studied in the metric space of compact subsets. Despite the loss of linearity, one can transfer most of the basic results of differential calculus and differential equations in vector spaces to mutational calculus and mutational equations in any mutational space, including naturally the space of nonempty compact subsets. "Mutational and Morphological Analysis" offers a structure that embraces and integrates the various approaches, including shape optimization and mathematical morphology. Scientists and graduate students will find here other powerful mathematical tools for studying problems dealing with shapes and images arising in so many fields.




Assessing Genetic Risks


Book Description

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.




Set-Valued Analysis


Book Description

"An elegantly written, introductory overview of the field, with a near perfect choice of what to include and what not, enlivened in places by historical tidbits and made eminently readable throughout by crisp language. It has succeeded in doing the near-impossible—it has made a subject which is generally inhospitable to nonspecialists because of its ‘family jargon’ appear nonintimidating even to a beginning graduate student." —The Journal of the Indian Institute of Science "The book under review gives a comprehensive treatment of basically everything in mathematics that can be named multivalued/set-valued analysis. ...The book is highly recommended for mathematicians and graduate students who will find here a very comprehensive treatment of set-valued analysis." —Mathematical Reviews "This book provides a thorough introduction to multivalued or set-valued analysis... The style is lively and vigorous, the relevant historical comments and suggestive overviews increase the interest for this work...Graduate students and mathematicians of every persuasion will welcome this unparalleled guide to set-valued analysis." —Zentralblatt Math




Biotechnologies for Plant Mutation Breeding


Book Description

This book is open access under a CC BY-NC 2.5 license. This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.




Mutation-Driven Evolution


Book Description

The purpose of this book is to present a new theory of mutation-driven evolution, which is based on recent advances in genomics and evolutionary developmental biology. This theory asserts that the driving force of evolution is mutation and natural selection is of secondary importance.







Principles of Bone Biology


Book Description

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition




Mutation


Book Description

In this masterpiece of techno-medical suspense from the “master of the medical thriller” (The New York Times), Robin Cook tells the explosive tale of a brilliant doctor who sought to create the son of his dreams—and invented a living nightmare... When OB/GYN and biomolecular researcher Dr. Victor Frank learns of his wife’s infertility, he initiates a bold—and dangerous—experiment. Unbeknownst to everyone, including her, Dr. Frank has adapted the methods of animal husbandry and molecular genetics to human reproduction. Fusing his wife’s eggs and his own sperm, he sets in motion the production of a superior being, his child. The result of this experiment, a son, VJ, is born to a surrogate mother and legally adopted by the Franks. To their delight, their son is physically perfect, and by the age of three, displays the complex problem-solving abilities of a prodigy. Then, without warning, VJ’s intelligence level plunges to a point appropriate to his age, but stabilizes. For the moment, Dr. Frank can breathe a sigh of relief: even if VJ is no longer the genius he was, at least he will be normal. But that relief is tragically short-lived, for all too soon VJ begins to change again. And this time, there is no cause for comfort—only terror.




Mouse Phenotypes


Book Description

The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.




Mobilizing Mutations


Book Description

With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.