Advanced Drug Delivery Systems in the Management of Cancer


Book Description

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. - Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer - Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers - Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems




New Look to Phytomedicine


Book Description

New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research. - Compiles up-to-date information on the chemotherapeutics used in the treatment of infective and metabolic disorders - Presents advancements in the discovery of new drugs from plants using molecular and nanotechnology tools - Examines detailed information on the use of herbals agents in cancer, HIV and other ailments, including diabetes, malaria and neurological disorders




Nano-formulation of Dietary Phytochemicals for Cancer Management


Book Description

This book covers various cancer chemotherapeutics, offering research-oriented overviews of phytochemical-based cancer treatments. It contrasts nano-formulated phytochemical delivery with conventional chemotherapy, introducing nanocarriers or bioengineering for poly-chemotherapy and phytochemicals as alternative treatments to reduce resistance. The text elaborates on the nano-formulation techniques and synthesis approaches of phytochemicals as drugs, the targeted drug delivery facilitated by nanocarriers, and subsequent mechanisms of drug release. Additionally, it examines the implications of nano-formulated phytochemicals in cancer therapeutics and their impact on cancer treatment and prevention. By enhancing bioavailability and improving functional qualities through nanoencapsulation, this innovative approach promises significant advancements in cancer therapy. Key concepts include dietary phytochemicals' role in various types of cancer chemotherapeutics, the pharmacological mechanisms of action in prevention and treatment, and strategies to enhance chemotherapy and radiotherapy efficacy. The book also presents preclinical and clinical studies on the efficacy of phytochemicals in cancer treatment. Additionally, it highlights improvements in drug delivery systems using nanotechnology-based dosage forms for herbal drugs. The content is designed for professionals involved in drug development, including chemists, pharmacists, biologists, biotechnologists, industrialists, nanotechnologists, microbiologists, economists, and all disciplines related to cancer treatment and phytochemical-based drug development. Academic students, scientists, and researchers at universities, institutes, hospitals, botanical institutes, pharmaceutical industries, government organizations, and NGOs will find invaluable insights into the application of phytochemical drugs in cancer treatment. By providing a detailed examination of cutting-edge research on nano-formulated phytochemicals for cancer therapy, this book invites readers to rethink traditional approaches to chemotherapy and explore innovative solutions that promise better outcomes for patients worldwide.




Dietary Phytochemicals


Book Description

This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.




Nanomaterials and Environmental Biotechnology


Book Description

Nanotechnology is considered as one of the emerging fields of science. It has applications in different biological and technological fields which deal with the science of materials at nanoscale (10-9). On the other hand, biotechnology is another field that deals with contemporary challenges. Nanobiotechnology fills the gap between these two fields. It merges physical, chemical, and biological principles in a single realm. This combination opens up new possibilities. At nanoscale dimensions, it creates precise nanocrystals and nanoshells. Integrated nanomaterials are used with modified surface layers for compatibility with living systems, improved dissolution in water, or biorecognition leading to enhanced end results in biotechnological systems. These nanoparticles can also be hybridized with additional biocompatible substances in order to amend their qualities to inculcate novel utilities. Nanobiotechnology is used in bioconjugate chemistry by coalescing up the functionality of non-organically obtained molecular components and biological molecules in order to veil the immunogenic moieties for targeted drug delivery, bioimaging and biosensing. This book blends the science of biology, medicine, bioinorganic chemistry, bioorganic chemistry, material and physical sciences, biomedical engineering, electrical, mechanical, and chemical science to present a comprehensive range of advancements. The development of nano-based materials has made for a greater understanding of their characterization, using techniques such as transmission electron microscope, FTIR, X-ray diffraction, scanning electron microscope EDX, and so on. This volume also highlights uses in environmental remediation, environmental biosensors and environmental protection. It also emphasizes the significance of nanobiotechnology to a series of medical applications viz., diagnostics, and therapeutics stem cell technology, tissue engineering enzyme engineering, drug development and delivery. In addition this book also offers a distinctive understanding of nanobiotechnology from researchers and educators and gives a comprehensive facility for future developments and current applications of nanobiotechnology.




NanoNutraceuticals


Book Description

This book will be a comprehensive account of the various facets of nutraceuticals domain. The peruser of this book will find details on various nanotech approaches to nutraceuticals, prebiotics and probiotics, along with their specific applications.




A Theranostic and Precision Medicine Approach for Female-Specific Cancers


Book Description

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care




Natural Products for Cancer Prevention and Therapy


Book Description

This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients




Nanophytomedicine


Book Description

Nanophytomedicine is a field that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology. This book assesses the clinical successes and failures of nanophytomedicine and also highlights emerging concepts in this field. The content is divided into three sections, the first of which describes core issues in the pharmaceuticals industry in connection with the successes, failures and prospects of nanophytomedicine. The second section highlights recent advances in phytomedicine formulation development based on nanotechnology approaches, while also discussing a variety of nanocarrier systems for the successful delivery of phytomedicines. Focusing on the clinical perspective, the third section addresses the current clinical status of nanophytomedicine as a single drug therapy or combinatorial drug therapy, pharmacovigilance, pharmacokinetics, drug interactions and toxicological profiles, while also providing concluding remarks on recent experimental findings, and considering ethical issues & regulatory challenges in nanophytomedicine. Given its scope, the book offers a valuable guide for early career researchers, young scientists, master level students, academics and industrial scientists working in various healthcare fields, e.g. the pharmaceutical and biological sciences, life sciences, biotechnology, biomedical engineering, and nanobiotechnology.




Nutraceuticals and Cancer


Book Description

This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.