› › Nanoparticles Induce Oxidative And Endoplasmic Reticulum Stresses

Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses

Author : Loutfy H. Madkour

Publisher :

Page : 742 pages

File Size : 31,61 MB

Release : 2020

Category : Nanoparticles

ISBN : 9783030372989

Get eBook

Book Description

This book provides insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. It presents the recent advances in new nanomedication technologies of the effects of nanoparticles NPs on oxidative stress, RONS and ER stress. The book comprises 13 chapters covering ecotoxicology, cytotoxicity, nanotoxicity and genotoxicity mechanisms causing by the role and interactions of nanoparticles and free radicals with (RONS) and (ER) stress. Endoplasmic Reticulum (ER) Stress as a mechanism for NPs induced toxicity has been discussed. The advances of nanotechnology and the effects of nanoparticles on oxidative stress, ROS and ER stress parameters are discussed. Antioxidants, therapeutic options and regulation of the immune responses are explained throughout the book.



Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses

Author : Loutfy H. Madkour

Publisher : Springer

Page : 696 pages

File Size : 11,73 MB

Release : 2020-03-14

Category : Technology & Engineering

ISBN : 9783030372965

Get eBook

Book Description

This book provides insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. It presents the recent advances in new nanomedication technologies of the effects of nanoparticles NPs on oxidative stress, RONS and ER stress. The book comprises 13 chapters covering ecotoxicology, cytotoxicity, nanotoxicity and genotoxicity mechanisms causing by the role and interactions of nanoparticles and free radicals with (RONS) and (ER) stress. Endoplasmic Reticulum (ER) Stress as a mechanism for NPs induced toxicity has been discussed. The advances of nanotechnology and the effects of nanoparticles on oxidative stress, ROS and ER stress parameters are discussed. Antioxidants, therapeutic options and regulation of the immune responses are explained throughout the book.



Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms

Author : Loutfy H. Madkour

Publisher : Academic Press

Page : 782 pages

File Size : 49,18 MB

Release : 2020-06-27

Category : Medical

ISBN : 0128224967

Get eBook

Book Description

Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment



Interaction of Nanomaterials with the Immune System

Author : James C. Bonner

Publisher : Springer Nature

Page : 229 pages

File Size : 37,13 MB

Release : 2020-01-30

Category : Medical

ISBN : 3030339629

Get eBook

Book Description

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.



Oxidative Stress and Biomaterials

Author : Thomas Dziubla

Publisher : Academic Press

Page : 405 pages

File Size : 30,59 MB

Release : 2016-05-31

Category : Technology & Engineering

ISBN : 0128032707

Get eBook

Book Description

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. - Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death - Brings together the two fields of biomaterials and the biology of oxidative stress - Provides approaches for the design of biomaterials with improved biocompatibility



Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Author : Sajal Chakraborti

Publisher : Springer Nature

Page : 4078 pages

File Size : 21,76 MB

Release : 2022-09-28

Category : Medical

ISBN : 9811654220

Get eBook

Book Description

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​



Human Immune System

Author : Shyamasree Ghosh

Publisher : Walter de Gruyter GmbH & Co KG

Page : 189 pages

File Size : 11,66 MB

Release : 2022-02-21

Category : Science

ISBN : 3110654229

Get eBook

Book Description

The fast development in the field of nanotechnology has led to a high variety of nanoparticles. Nanoparticles find importance in every sphere of human lives and more so in the recent years have tremendous applications in the sector of biomedical clinical medicine as diagnostic, prognostic and imaging tools. Their risk to human and animal life as well as to the environment is still unclear. Therefore, the study of the impact of nanoparticles on human and animal life is important. Volume I highlights the impact of nanoparticles on the human immune system. While discussing the basic biology of the immune system, this book highlights the downstream effect of nanoparticles on the human immune system. Research studies on the development of better and more effective nanoparticles with more precise and accurate effects and with toxic minimal side effects are discussed in the book. Both volumes are also included in a set ISBN 978-3-11-065666-4.



Diverse Applications of Nanotechnology in the Biological Sciences

Author : Khalid Rehman Hakeem

Publisher : CRC Press

Page : 391 pages

File Size : 40,38 MB

Release : 2022-06-30

Category : Medical

ISBN : 1000564916

Get eBook

Book Description

Diverse Applications of Nanotechnology in the Biological Sciences: An Essential Tool in Agri-Business and Health Care Systems explores the diverse roles that nanobiotechnology plays in the medical sciences, pharmacy, healthcare, and in plants and agriculture. Looking at the diverse applications of nanotechnology in the healthcare field, the chapter authors discuss its importance in drug delivery, biomedical imaging and medical diagnostics, and healthcare management. The volume emphasizes how nanomedicine can treat different types of cancers and can improve medical imaging for the diagnosis of different kinds of diseases, resulting in quicker and more accurate diagnosis and better treatment options. The volume delves into nanobiotechnology in plants and its application in nanofertilizers and nano-pesticides in agriculture. It also documents how agri-nanobiotechnology can be a tool for innovative green technology that can be applied for global food security, biodiversity, and climate change solutions. The themes of nanobiotechnology in medicine and in plants are merged in the chapter on the types and therapeutic effects of plant product-based nanomedicine for malignancies. The potential toxicity of nanoparticles in plants is also elucidated. This volume provides an insightful overview of nanobiotechnology in medicine and in plants and agriculture that will be valuable for researchers and scientists and faculty and students in the areas of nanobiotechnology, agriculture, plant molecular biology, and medicine and healthcare.



Nanoparticle Drug Delivery Systems for Cancer Treatment

Author : Hala Gali-Muhtasib

Publisher : CRC Press

Page : 342 pages

File Size : 22,43 MB

Release : 2020-02-19

Category : Medical

ISBN : 1000680878

Get eBook

Book Description

In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.



Nanoparticle-Based Drug Delivery in Cancer Treatment

Author : Loutfy H. Madkour

Publisher : CRC Press

Page : 559 pages

File Size : 22,72 MB

Release : 2022-02-27

Category : Science

ISBN : 100053216X

Get eBook

Book Description

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.