New Developments in Array Technology and Applications


Book Description

IAU Symposium No. 167 brought together researchers who use CCDs and arrays, designers and manufacturers of CCDs and Array Mosaics and those who write the software to control these devices and to reduce the large amounts of data contained in each frame. At the meeting such topics as plans for applying the new technology to the new large telescopes that have been built recently and those planned in the near future, new developments in infrared arrays, advances and concerns with the use of CCDs in photometry and spectroscopy and the creation of large mosaics in photometry and spectroscopy and the creation of large mosaics of chips which allow larger areas of the sky to be covered in a single frame were discussed. There were sessions devoted to the following topics: New Developments in CCD Technology; New Developments in IR Detector Arrays; Direct Imaging with CCDs and Other Arrays; Spectroscopy with CCDs and Other Arrays; and Large Field Imaging with Array Mosaics. Scientific results of studies made with this technology were covered in the poster sessions. CCD and Array Detectors have become the detectors of choice at all the world's optical observatories. Such instruments on small university and college telescopes have turned these telescopes into instruments that can now do observations which in the past were done only on the largest telescopes. CCDs and Arrays are known as `the people's detector' because of their ability to turn small telescopes into true research instruments. On large telescopes observations can be made of extremely faint and crowded objects that were impossible to observe before the advent of CCD and Array technology. The proceedings of this meeting will be useful to all those who are interested in the design, manufacture and use of CCDs and Arrays for astronomical observations.




Microarray Innovations


Book Description

In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr




Advanced Array Systems, Applications and RF Technologies


Book Description

Advanced Array Systems, Applications and RF Technologies adopts a holistic view of arrays used in radar, electronic warfare, communications, remote sensing and radioastronomy. Radio frequency (RF) and intermediate frequency (IF) signal processing is assuming a fundamental importance, owing to its increasing ability to multiply a system's capabilities in a cost-effective manner. This book comprehensively covers the important front-end RF subsystems of active phased arrays, so offering array designers new and exciting opportunities in signal processing. - Provides an up to date record of existing systems from different applications - Explores array systems under development - Bridges the gap between textbook coverage of idealized phased arrays and practical knowledge of working phased arrays - Recognises the significance of cost to the realization of phased arrays - Discusses future advances in the field that promise to deliver even more affordable arrays ['intelligent' or self-focussing/-cohering arrays]










Microarray Technology and Its Applications


Book Description

Ithasbeenstatedthatourknowledgedoublesevery20years,butthatmaybe an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA isthegeneticmaterialtoabasicmolecularunderstandingofourselvesandthe living world around us in less than 50 years. Crucial to this rapid progress was thediscoveryofthedouble-helicalstructureofDNA,whichlaidthefoundation forallhybridizationbasedtechnologies. Thediscoveriesofrestrictionenzymes, ligases, polymerases, combined with key innovations in DNA synthesis and sequencing ushered in the era of biotechnologyas a new science with profound sociological and economic implications that are likely to have a dominating in?uence on the development of our society during this century. Given the process by which science builds on prior knowledge, it is perhaps unfair to single out a few inventions and credit them with having contributed most to thisavalancheofknowledge. Yet,therearesurelysomethatwillberecognized as having had a more profound impact than others, not just in the furthering of our scienti?c knowledge, but by leveraging commercial applications that provide a tangible return to our society. The now famous Polymerase Chain Reaction, or PCR, is surely one of those, as it has uniquely catalyzed molecular biology during the past 20 years, and continues to have a signi?cant impact on all areas that involve nucleic acids, ranging from molecular pathology to forensics. Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.




Antibodies Applications and New Developments


Book Description

Antibodies Applications and New Developments is an overview of the current developments of techniques and methods relating to immunodiagnostics and immunoanalysis. This eBook also deals with specialties in the fields of drug, pesticide, antigen and food contaminant detection. The volume is useful for professional immunologists and biotechnologists interested in antibody research and development.




Microarrays


Book Description

Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments. Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probes, bifunctional reagents NTMTA and NTPAC, and high density arrays using digital microarray synthesis platforms. Other topics include multiplex ligation-dependent probe amplification (MLPA), hybridization conditions in situ-synthesized oligo arrays, peptide arrays, high density replication tools (HDRT), protocols for the quantification of oligo hybridization, glyco-bead arrays, and an investigation into the emerging nano technology. Microarray Technology, Volumes 1 and 2, provide ample information to all levels of scientists from novice to those intimately familiar with array technology.




Cytometry: New Developments


Book Description

The chapters in CYTOMETRY MCB volumes, including this 4th Edition, provide comprehensive description of particular cytometric methods and review their applications. Some chapters also describe new instrumentation and provide fundamental information on use of new fluorescent probes and on data analysis. Although the term "edition" suggests the update of earlier volumes, in fact, nearly all chapters of the 4th Edition are devoted to new topics. The authors were invited to present not only technical protocols, such as available in other methodology books that specialize in the protocol format, but also to discuss the aspects of the methodology that generally are not included in the protocols. Many chapters, thus, present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical setting, common traps and pitfalls, problems with data interpretation, comparison with alternative assays, choice of the optimal assay, etc. Some chapters review applications of cytometry and complementary methodologies to particular biological problems or clinical tasks. - Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays - Discusses many new assays developed since the previous edition - Presents recent developments in cytometric intrumentation/technology