New Frontiers in Mammary Pathology 1986


Book Description

Society The Third Symposium of the International held in against Breast Cancer CONTRA CANCRUM MAMMARIUM was Paris, at UNESCO, on December 9-12, 1985. Scientists and physicians came from allover the world to attend this meeting. They came from Japan, Brazil, the United States and the Middle East, from Belgium, Finland, Germany, Greece, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, Yugoslavia, and from allover France. They all contributed to the success of the Symposium and my cordial thanks go to all of them and particularly to the invited speakers and chairmen of the sessions, to the free-paper contributors, and to the contributors to the Slide Seminar. Warm personal thanks go to two friends: to Professor Dan H. Moore from Hahnemann University, Philadelphia, who was always there to help in many ways, and to Professor Pietro Gullino from the National Cancer Institute, Bethesda, and now Torino, Italy, who consistently gave invaluable advice. Special thanks are also due to those who assisted in the preparation and organization of the Symposium: the UNESCO officers, the interpreters, the secretaries and hostesses, the BEBA Company with the help of Dr.Bernard Martin and Mrs.Jacqueline Bouchy, the WILD LEITZ-France S.A. for projection facilities and microscope arrangements for the workshop on mammary cytology which was successfully conducted by Dr.Colette Marsan. During the four days,three main topics were discussed: ~ E~idemiology, genetiCS and oncogenes, related subjects of great actuality.




New Frontiers in Cytology


Book Description

Diagnostic cytology has recently enjoyed increased attention and significance in modern research. Essential information on latest developments in methods and applications in cytology is provided by this book. Chapters review methodological advances, such as in cancer detection, and explore potential relationships to molecular biology. Also discussed are: viral infection, fundamentals of quantitative methods, and the revolutionary role of immunocytochemistry in diagnostic cell typing. The new insights offered by transmission and scanning electron microscopy into cellular structure and function are discussed, and the connections between cytology and histology are highlighted. Epidemiology in connection with cytology is incorporated in special reports. The current developments described here will become routine methods of the cytology of tomorrow.




Current Catalog


Book Description

First multi-year cumulation covers six years: 1965-70.







New Trends in Gastric Cancer


Book Description

Despite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate diagnosis and treatment since it has a high mortality rate. In June 1989 an International Conference was held at the University of Rome "La Sapienza" entitled "New Trends in Gastric Cancer: Background and videosurgery". During this meeting background information on the aetiopathogenesis of gastric cancer was presented together with talks and video presentations on the latest advances in the treatment of gastric carcinoma, both from the European and Japanese experience. Because of the poor prognosis of gastric carcinoma there is increasing pressure for early detection. Some of the problems in the early detection of gastric carcinoma are discussed together with methods of surveillance of high-risk subjects. It is generally accepted that the surgical approach to gastric carcinoma should take into account the site and extent of the lesion and there are chapters on new methods for pre and intraoperative staging of the disease which allow a more logical approach to surgery. A comparison between Japanese and Western rule and results was attempted and reasons for the differences were investigated. Since the field is still evolving not all aspects could be covered, and those angles not approached in this book will be addressed in a second International Conference to be held in Rome in June 1990.




Magnetic Resonance in Experimental and Clinical Oncology


Book Description

Over the past decade, techniques have been developed and implemented to observe metabolism noninvasively in localized regions of intact, living experimental animals and humans through the use of magnetic resonance spectroscopy (MRS). At the same time, magnetic resonance imaging (MRI) techniques developed in the 1970s and refined in this decade have been increasingly applied as a powerful clinical tool to probe human anatomy. Because of the unusual metabolic and physiologic characteristics of malignant tissues, oncology has been one of the primary focuses of the application of both MRS and MRI. Although considerable progress has been made in oncologic applications of magnetic resonance (MR), further research is needed to realize the full potential of MR in this area. Consequently, the 21st Annual Detroit Cancer Symposium entitled "Magnetic Resonance in Experimental and Clin ical Oncology" was organized to provide a forum for researchers in the field to report the state of the art of MRS and MRI in oncol ogy, to discuss future goals for MRS and MRI in oncology, and to define the research needed to meet those goals. The major emphasis of the symposium was on MRS due to both the recent widespread availability of clinical MRS instrumentation and the extensive amount of animal MRS research performed over the past half decade.




Childhood Leukemia: Present Problems and Future Prospects


Book Description

Twenty years ago when Children's Cancer Association of Japan was born, the diagnosis of childhood leukemia amounted to a death sentence. Only 20% or so of children with leukemia survived more than 5 years. Since then, enormous improvements have been achieved regarding our understanding on the etiology, diagnosis, and the treatment of childhood leukemia. Now, 70% of children with leukemia survive and enter adult life. Even though the improved survival rate of children with leukemia represents a medical success story, we now face new problems. The first problem is the fact that we still lose 20-30% of patients with childhood leukemia. To address this problem, we need to understand the etiology, epidemiology, and biology of leukemia; to identify the patients at greater risk; and to develop adequate treatments. The second problem is the treatment itself. Even though efficacious, the modem treatment for leukemia is a grueling experience for children and their families. We should develop a total care system for families and children based on a deep understanding of their needs. The third problem is the aftereffects of the treatment and of cured leukemia. Extensive radiation and chemotherapy have an entirely different spectrum of long-term effects on children than on adults. These treatments in the early stage of life, when the mind and body are developing, create many physical and psychological problems. These are the present problems of childhood leukemia.




Women at High Risk to Breast Cancer


Book Description

A reprint of the 1989 edition of this book has been made necessary by continuing demand after rapid exhaustion of the first printing. In the two years since its appearance, there has been relatively little expansion of knowledge on this topic, and its massive accumulation of references still remains an authoritative guide in the difficult task of developing a national breast cancer prevention model. At the same time, its thesis has been sharpened by the publication of a companion volume Approaches to Breast Cancer Prevention (Kluwer, 1991) similarly edited byrne. Breast cancer is on the increase throughout the Western world where it is a major source of anxiety among women. The disease is also becoming more frequent in Asian and South American countries where once it was relatively uncommon. Multiple fac tors are suspected of promoting the disease and the increasing risk is attributed to recent changes in life-style and diet. This book is intended to provide an authorita tive and balanced survey of the latest research into the genetic, familial, hormonal, reproductive, nutritional, social and geographic factors known to be associated with an increased predisposition to the disease.




Causation and Prevention of Human Cancer


Book Description

The European Organization for Cooperation in Cancer Prevention Studies (ECP) was established in 1981 to promote collaboration between scientists working in the various European countries on cancer causation and prevention. In order to achieve this aim, various working group- to deal with specific cancers or aspects of cancer aetiology, and to explore the opportunities for advances on a cooperative European basis - were established. It was also decided to hold annual symposia to draw general attention to fields in which there seemed to be many opportunities for progress in matters of prevention. These symposia have been devoted to themes of high priority to cancer prevention: "Tobacco and Cancer" (1983), "Hormones and Sexual Factors in Human Cancer Aetiology" (1984), "Diet and Human Carcinogenesis" (1985), "Concepts and Theories in Carcinogenesis" (1986)," Preventive Strategies for Cancer related to Immune Deficiencies" (1987), "Gastric Carcinogenesis" (1988), and "Breast, Ovarian and Endometrial Cancer: Aetiological and Epidemiological Relationships" (1989). This volume contains the proceedings of the 1990 ECP symposium held in Heidelberg, FRG, at the Deutsches Krebsforschungszentrum (DKFZ), on April 2-3 on "Causation and Prevention of Human Cancer". We are indebted to the speakers for their contribution during the symposium and for their prompt submission of manuscripts. We are grateful to the sponsors, SmithKline Diagnostics and Rohm Pharma. Our special thanks go to Dr M.C. stanei-Gueur for preparing and typing the camera forms of all manuscripts.




Application of Monoclonal Antibodies in Tumor Pathology


Book Description

The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues. During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. Although monoclonal antibodies to tumor associated antigens have not become yet routine reagents in immunopathology, they have provided new information which could not be obtained with conventional antisera or histochemical procedures. The following are representative examples. TUmor associated antigens have been identified which display a restricted distribution in normal tissues and therefore may represent useful markers for radio imaging and appropriate targets for immunotherapy. In spite of undetec table differences with conventional histopathological approaches hetero geneity has been found in the antigenic profile of tumor cells within a lesion, in autologous lesions removed from different anatomic sites from a given patient and in lesions removed from different patients. Phenotypes of tumor cells have been identified which correlate with the biology of tumor cells and with the clinical course of the disease. From a practical view point the use of monoclonal antibodies in immunopathology has enhanced interactions between pathologists and immunologists, as exemplified by the present book. Such interactions have contributed to the application of basic research to clinical problems. The chapter of this book discuss investigations performed with monoclonal antibodies to antigens expressed by various types of normal and malignant human cells.