New Insights into Brain Imaging Methods for Rehabilitation of Brain Diseases


Book Description

Brain diseases such as stroke, Alzheimer's disease, and Parkinson's disease cause dysfunction in multiple body systems. Motor dysfunction, cognitive impairment, dysphagia, and emotion disorders are frequently observed in patients with brain diseases. As the dysfunctions are associated with alterations in the brain, brain imaging methods such as functional MRI (fMRI), electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and transcranial magnetic stimulation (TMS) are essential for investigating the neural mechanisms underlying the dysfunction caused by brain diseases. Brain imaging methods are also critical for understanding the neural mechanisms for the effectiveness of therapeutic or rehabilitative interventions that promote recovery from brain diseases. The usage of these brain imaging methods would deepen our understanding of brain diseases and potentially translate this knowledge to improve effectiveness of rehabilitative interventions for brain diseases.




Brain Imaging in Behavioral Neuroscience


Book Description

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.




Stroke Rehabilitation


Book Description

Stroke Rehabilitation: Insights from Neuroscience and Imaging informs and challenges neurologists, rehabilitation therapists, imagers, and stroke specialists to adopt more restorative and scientific approaches to stroke rehabilitation based on new evidence from neuroscience and neuroimaging literatures. The fields of cognitive neuroscience and neuroimaging are advancing rapidly and providing new insights into human behavior and learning. Similarly, improved knowledge of how the brain processes information after injury and recovers over time is providing new perspectives on what can be achieved through rehabilitation. Stroke Rehabilitation explores the potential to shape and maximize neural plastic changes in the brain after stroke from a multimodal perspective. Active skill based learning is identified as a central element of a restorative approach to rehabilitation. The evidence behind core learning principles as well as specific learning strategies that have been applied to retrain lost functions of movement, sensation, cognition and language are also discussed. Current interventions are evaluated relative to this knowledge base and examples are given of how active learning principles have been successfully applied in specific interventions. The benefits and evidence behind enriched environments is reviewed with examples of potential application in stroke rehabilitation. The capacity of adjunctive therapies, such as transcranial magnetic stimulation, to modulate receptivity of the damaged brain to benefit from behavioral interventions is also discussed in the context of this multimodal approach. Focusing on new insights from neuroscience and imaging, the book explores the potential to tailor interventions to the individual based on viable brain networks.




Insights in Brain Imaging Methods: 2023


Book Description

Following on from the success of Insights in Brain Imaging Methods: 2021, we would like to further celebrate the exceptional achievements made by scientists, leading to major advancements in the fast-growing field of neuroscience. You can find the 2021 edition here. Frontiers is continuing to organize a series of Research Topics to highlight the latest advancements in research across the field of neuroscience, with articles from the members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Prof Vince D Calhoun, Specialty Chief Editor of the Brain Imaging Methods section, together with Professors Federico Giove and Xi-Nian Zuo, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Brain Imaging Methods.




Imaging of the Human Brain in Health and Disease


Book Description

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease




Imaging Dementia


Book Description

This book helps physicians select from among the currently available imaging tools, promoting the correct and cost-saving diagnosis and management of common dementias. Magnetic resonance (MR) and nuclear medicine techniques are routinely used to facilitate diagnosis, select therapies, provide information regarding the prognosis, and monitor therapy response in patients with cognitive impairment and dementia. Furthermore, the advent of quantitative MR techniques, such as diffusion-weighted imaging, perfusion imaging, etc. have opened up new opportunities to diagnose neurological diseases based on objective findings, and offer unique new insights into the main neurodegenerative diseases of the human brain. However, the practical value of various neuroimaging techniques in clinical practice has yet to be clearly defined, and their potential for future development is not yet fully appreciated. To help remedy the situation, this book offers practical and useful algorithms and rules that can be directly applied in the clinical setting. It provides concise content, together with a wealth of clinical case material.




The Neuroimaging of Brain Diseases


Book Description

Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they use. By focusing on both structure and function this book will provide a strong foundation for emerging developments in the field.




The Magic of Brain Scans Understanding the Power of Imaging Techniques


Book Description

Overview of Brain ImagingBrain imaging is a powerful tool that has revolutionized our understanding of the human brain. This subchapter provides a comprehensive overview of brain imaging techniques, shedding light on how they work and the invaluable insights they offer. The human brain is a complex organ responsible for controlling our thoughts, emotions, and behaviors. Understanding its intricate workings has long been a challenge for scientists. However, advancements in brain imaging have opened up new avenues for unraveling the mysteries of the brain. There are several types of brain imaging techniques, each offering a unique perspective on the brain's structure and function. Magnetic Resonance Imaging (MRI) is one of the most commonly used techniques. It uses a powerful magnetic field and radio waves to create detailed images of the brain's anatomy. MRI provides high-resolution images that can help identify abnormalities, such as tumors or lesions, and aid in the diagnosis of various neurological conditions. Another widely used technique is Functional Magnetic Resonance Imaging (fMRI). Unlike MRI, fMRI focuses on brain activity rather than structure. It measures changes in blood flow and oxygenation to infer which regions of the brain are active during specific tasks or stimuli. This technique has been instrumental in mapping brain functions and understanding how different brain regions communicate and work together. Positron Emission Tomography (PET) is another important brain imaging technique. It involves injecting a small amount of a radioactive substance into the bloodstream, which is then detected by a scanner. PET scans provide information about brain metabolism and can be used to study various aspects of brain function, such as glucose consumption or neurotransmitter activity. In addition to these techniques, there are also others like Electroencephalography (EEG), which records electrical activity in the brain, and Magnetoencephalography (MEG), which measures magnetic fields generated by neural activity. These techniques provide valuable insights into the brain's electrical and magnetic signals, aiding in the diagnosis and treatment of conditions like epilepsy and sleep disorders. Brain imaging has revolutionized our understanding of the human brain, enabling scientists to study its structure and function in unprecedented detail. It has helped uncover new insights into neurological disorders, improve treatment strategies, and even enhance our understanding of cognitive processes such as perception, attention, and memory




Dynamic Brain Imaging


Book Description

If a picture is worth a thousand words, then dynamic images of brain activity certainly warrant many, many more. This book will help users learn to decipher the dynamic imaging data that will be critical to our future understanding of complex brain functions. In recent years, there have been unprecedented methodological advancements in the imaging of brain activity. These techniques allow the measurement of everything from neural activity (e.g., membrane potential, ion ?ux, neurotransmitter ?ux) to energy metabolism (e.g., glucose consumption, oxygen consumption, creatine kinase ?ux) and functional hyperemia (e.g., blood ?ow, volume, oxygenation). This book deals with a variety of magnetic resonance, electrophysiology, and optical methods that are often used to measure some of these dynamic processes. All chapters were written by leading experts, spanning three continents, specializing in state-of-the-art methods. Brie?y, the book has ?ve sections. In the introductory section, there are two chapters; the ?rst one contains a brief pre- ble to dynamic brain imaging and the other presents a novel, analytical approach to processing of dynamically acquired data. The second section has four chapters and delves into a wide range of optical imaging methods. I am privileged to include a chapter from Lawrence B. Cohen, considered by many to be the authority on optical imaging and spectroscopy, both in vitro and in vivo [Cohen LB (1973) Physiol Rev.




Brain Neurotrauma


Book Description

With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.