Non-coding RNA in immunotherapies and immune regulation
Author : Bertrand Kaeffer
Publisher : Frontiers Media SA
Page : 203 pages
File Size : 15,51 MB
Release : 2023-01-02
Category : Medical
ISBN : 2832510361
Author : Bertrand Kaeffer
Publisher : Frontiers Media SA
Page : 203 pages
File Size : 15,51 MB
Release : 2023-01-02
Category : Medical
ISBN : 2832510361
Author : Adam Williams
Publisher : Frontiers Media SA
Page : 68 pages
File Size : 30,74 MB
Release : 2021-06-29
Category : Medical
ISBN : 2889669173
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author : Yanyan Tang
Publisher : Frontiers Media SA
Page : 446 pages
File Size : 29,46 MB
Release : 2022-09-14
Category : Science
ISBN : 2889769577
Author : Shuai Jiang
Publisher : Academic Press
Page : 316 pages
File Size : 41,21 MB
Release : 2022-05-15
Category : Medical
ISBN : 9780323855044
Advances in Non-coding RNAs in Cancer-Biology and Immunology is a resource for three major types of non-coding RNAs including microRNA, LnRNA and piRNA. It covers machinery of non-coding RNAs, including microRNA, LnRNA and piRNA, and the identification of targets of these non-coding RNAs, and the identification of physiological and pathological roles of miRNAs, LnRNAs and piRNAs in immunology and cancer biology. The aberrant expressions of these non-coding RNAs within the cells cause various abnormalities and diseases including cancer and immune system-associated diseases. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. Advances in Non-coding RNAs in Cancer-Biology and Immunology introduces basic ideas of miRNAs, LnRNAs and piRNAs, along with their detailed bio-processing steps, critical functions in the development of tumorigenesis and controlling immune cell responses, which benefits for identifying different classes of non-coding RNAs and their targets, identifying new members of these non-coding RNAs and predicting the possible functions of these molecules. It captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs, LnRNAs, piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. Provides a unified cutting-edge resource for non-coding RNAs including miRNAs LnRNAs, and piRNAs, their physiological and pathological roles and potential applications Showcases high-throughput technologies and other approaches for discovery of these non-coding RNAs and their downstream targets Unveils the diverse molecular mechanisms by which miRNAs, LnRNAs and piRNAs regulate gene expression in animal cells Showcases recent discoveries on involvement of these non-coding RNAs in different biological processes and diseases as well as their possible use in diagnosis Reports breakthroughs in the use of these non-coding RNAs for diagnosis and personalized therapy
Author : Joanna Sztuba-Solinska
Publisher : Elsevier
Page : 450 pages
File Size : 18,69 MB
Release : 2023-06-17
Category : Science
ISBN : 0323907008
Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies Explores the molecular mechanisms and intermolecular interactions of ncRNA
Author : Nicholas Delihas
Publisher : MDPI
Page : 837 pages
File Size : 15,60 MB
Release : 2018-10-09
Category : Non-coding RNA.
ISBN : 3038420050
Printed Edition of the Special Issue Published in IJMS
Author : Jonathan J. Kotzin
Publisher :
Page : 262 pages
File Size : 42,1 MB
Release : 2017
Category :
ISBN :
The immune system is comprised of diverse cell types that work together to protect the host from infection and maintain tissue homeostasis. To achieve this complex balance, extracellular cues determine highly specific epigenetic landscapes and transcriptional profiles of each immune cell subtype. New evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in epigenetic and transcriptional regulation in mammals. Here we identify the lncRNA Morrbid, and examine its role in immune function. In Chapter 2, we assess the function of Morrbid at homeostasis and describe its role in finely tuning the lifespan of short-lived myeloid cells. In Chapter 3, we examine Morrbid under inflammatory conditions and illustrate its role in restraining CD8 T cell responses following viral infection. These data demonstrate that lncRNAs can function as highly cell-type specific effectors of extracellular cues to control immunological processes that require rapid and strict regulation.
Author : Lütfi Tutar
Publisher : BoD – Books on Demand
Page : 150 pages
File Size : 24,5 MB
Release : 2020-03-04
Category : Medical
ISBN : 1789856558
Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.
Author : Catherine M. Greene
Publisher : Springer
Page : 242 pages
File Size : 24,80 MB
Release : 2015-02-06
Category : Medical
ISBN : 3319136895
The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohn’s disease, diabetes) and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
Author : Kevin V. Morris
Publisher : Springer
Page : 267 pages
File Size : 18,54 MB
Release : 2016-04-13
Category : Medical
ISBN : 3319239074
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.