Noninvasive Imaging of Cardiac Metabolism


Book Description

F.J.Th. WACKERS Metabolic imaging: The future of cardiovascular nuclear imaging? Since cardiovascular nuclear imaging emerged as a new subspecialty in the mid-1970s, the field has gone through an explosive growth. Radionuclide techniques became readily recognized as important new diagnostic aids in the armamentarium of the clinical cardiologist. Initially, cardiovascular nuclear imaging focused on static myocardial imaging using either thallium-201 or technetium-99m-pyrophosphate for diagnosing acute myocardial infarction. Shortly thereafter, multigated equilibrium radionuclide angiocardiography became the most widely used noninvasive method for assessing cardiac function. Furthermore, attention and clinical application shifted towards the use of radionuclide techniques in conjunction with exercise testing, either with thallium-20 1 myocardial perfusion imaging or technetium-99m left ventricular function studies. The future of cardiovascular nuclear imaging appeared exciting and promising. However, around 1980 pessimists predicted the premature demise of cardiovascular nuclear imaging with the introduction of digital subtraction angiography and nuclear magnetic resonance imaging. These doomsayers have been proven wrong: in 1985 cardiovascular nuclear imaging is thriving and, in many centers, even expanding. Although digital substraction angiography and magnetic resonance imaging provided exquisite anatomic detail, for practical evaluation of patients with ischemic heart disease - in the Coronary Care Unit or exercise laboratory - nuclear techniques appeared to be more practical.




The Scientist's Guide to Cardiac Metabolism


Book Description

The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. - Provides a quick and comprehensive introduction into cardiac metabolism - Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs - Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function - Includes historical perspectives that reference important investigators that have contributed to the development of the field




Atlas of Nuclear Cardiology


Book Description

In Atlas of Nuclear Cardiology, Doctors Dilsizian and Narula have worked together with over a dozen leading authorities to capture the most up-to-date and pertinent information in the field of nuclear cardiology. This atlas is a modern and complete visual library of up-to-date information on the most current cardiovascular nuclear procedures in the clinical practice of cardiology. Together with detailed legends and extensive reference listings, the over 600 illustrations deliver comprehensive information. Diagnostic algorithms and schematic diagrams integrated with nuclear cardiology procedures are generously interspersed with color images to emphasize key concepts in cardiovascular physiology and metabolism. This vital reference provides a detailed and accurate insight into the noninvasive evaluation and quantification of myocardial perfusion, function, and metabolism.




Cardiac CT, PET and MR


Book Description

This careful revision keeps pace with developments in the field, with new chapters on PET Metabolism, CT and MRI in the Emergency Department, Image-Guided Electrophysiology Mapping and Ablation, and Identification of Vulnerable Atherosclerotic Plaque by Radionuclide and CT techniques, plus the introduction of new contributors Udo Hoffman and Stephan Achenbach. Praised in its previous edition as a concise source of essential information, this new edition presents the most recent information in an accessible format and serves as an excellent reference source for all cardiologists, radiologists and nuclear medicine physicians.




Coronary Microvascular Dysfunction


Book Description

In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.




Diseases of the Chest, Breast, Heart and Vessels 2019-2022


Book Description

This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.




Multimodality Imaging


Book Description

This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.




Handbook of Radiopharmaceuticals


Book Description

The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. Since the first edition of the Handbook was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: Features extensive new and revised content throughout Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Edited by recognized experts in radiochemistry and PET imaging, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, 2 nd Edition is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.




Myocardial Viability


Book Description

Despite remarkable advances in the understanding and management of impaired left ventricular function (LVF) and related coronary disease, the prevalence of heart failure in the U.S. and the resulting death rates have almost tripled in the past 3 decades. New understanding of the relationships between the myocardium and LVF demonstrate a direct correlation between myocardial viability and improved patient survival. Because of this, myocardial viability is now a major investigative area in contemporary cardiology, one that holds significant clinical and prognostic relevance. Authored by physicians of international renown, the book brings together various disciplines affecting myocardial viability, with five main sections providing an introduction and comprehensive review of: basic concepts and mechanisms; vascular biology and cellular physiology; advances in functional imaging; and perfusion, metabolism and cell membrane integrity. New concepts, such as stunning and hibernation, are clarified, and subsequent novel diagnostic and therapeutic strategies are described. New and sophisticated examination techniques are also presented, as well as advances in instrumentation and imaging techniques, which may result in improved use of resources and enhanced efficiency of health care delivery. This monograph will serve as a reference source for those interested in the field of myocardial viability, and hopefully improve understanding between investigators from various disciplines. Clinical cardiologists, physicians, and nurses in the field, as well as radiologists, vascular surgeons, reperfusionists, cellular biologists and physiologists, and students will all find material of interest in this book.




Nuclear Cardiac Imaging


Book Description

Nuclear cardiac imaging is the diagnostic technique of using radiology and chemical markers to track cardiac performance. These imaging studies provide a wide range of information about the heart, including how much the heart contracts, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armoury of diagnostic techniques. Iskandrian's text has become a leading book in the field and the fourth edition will continue the tradition. The text is updated throughout to reflect the many advances in the field, and, as a new feature, each chapter concludes with a question and answer session on important and difficult clinical issues.