Medicinal Chemistry of Anticancer Drugs


Book Description

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature




Dietary Interventions in Liver Disease


Book Description

Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. - Provides information on agents that affect metabolism and other health-related conditions in the liver - Explores the impact of composition, including differences based on country of origin and processing techniques - Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function







The Heart in Rheumatic, Autoimmune and Inflammatory Diseases


Book Description

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. - A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. - Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. - Presents an up-to-date "level of evidence and "strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.







Medical Botany


Book Description

Plants as Medicine.... A Natural Approach to Self-Health Medical Botany: Plants Affecting Man?s Health, Walter H. Lewis, Memory P.F. Elvin-Lewis Medical Botany is a fascinating look at the facts and fictions surrounding plants and man?not only which plants affect our bodies, but how they affect them. Authoritative, rich in anecdote and lore, lavishly illustrated, this encyclopedic reference brings within your reach the curative, healing, poisonous, allergenic, and psychoactive properties of thousands of plants. Its ready reference format allows you to turn instantly to information about a specific plant?s properties, its history, its use in orthodox medicine (where applicable) and its use in folk medicine. Discover a wealth of information on plants that have been used for such purposes as to treat peptic ulcers, to assist in the fight against cancer (in combination with chemotherapy), to help alleviate gout and diabetes, and to promote the healing of wounds. Each section begins with historical background of the plants discussed, with colorful stories ranging from Socrates? fatal hemlock to Timothy Leary?s experiments. There are informative discussions of how your body works, with sections covering heart and circulation, metabolism, nervous system, urogenital system, gastrointestinal tract, allergies, ear, internal poisons, and more. This intriguing compendium/reference will enlighten, entertain, and give you a healthier knowledge of plants. Praise for Medical Botany... "Skillfully organized, neatly written, highly informative, and well illustrated, this is a stimulating and useful reference volume. It is not a mere catalog of medicinal plants but a carefully prepared review of injurious, healing and nourishing, and psychoactive plants...should be a lasting joy for reference and a source of continued satisfaction..." ?American Scientist "I would recommend this text highly...useful for the layman who wishes an introduction to the topic. The authors have provided a fresh look at a classic subject and should be commended for their efforts." ?Economic Botany "...a vast compendium of information on medically important plants, both harmful and useful...commendable." ?New England Journal of Medicine