OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test


Book Description

The purpose of this test is to determine the effects of a substance on the growth of freshwater microalgae and/or cyanobacteria. Exponentially growing test organisms are exposed to the test substance in batch cultures over a period of normally 72 ...







OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP)


Book Description

In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...




Advances in Applied Microbiology


Book Description

Advances in Applied Microbiology, Volume 115 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on the preparation of functional oligosaccharides using microbial coupling fermentation. - Contains contributions from leading authorities in the field - Informs and updates on the latest developments in the field of microbiology - Includes discussions on the role of specific molecules in pathogen life stages, interactions, and much more




Environmentally Friendly and Biobased Lubricants


Book Description

A Comprehensive Review of Developing Environmentally Friendly Lubricants A push from environmentally savvy consumers along with recent changes in governmental regulations have paved the way for a marketplace of products with high levels of environmental performance. Fueled by the growing demand for biobased lubricants, Environmentally Friendly and Biobased Lubricants highlights the development of environmentally friendly additives that are compatible with environmental regulations and describes the approaches being used in this emerging area. Derived from research topics shared over the years at various technical sessions of the Society of Tribologists and Lubrication Engineers (STLE) Annual Meetings, the book includes a critical assessment of gaps and weaknesses in the field of environmentally friendly fluids and biobased lubricants. Each chapter is written by authors selected from the environmentally friendly fluids and biobased lubricants sessions of STLE and also incorporates input from prominent researchers invited to take part in the book. Expert contributors discuss the control, production, usage, and disposal of lubricants; factor in related policies, laws, and regulations around the world; and include case studies demonstrating the uses and values of commercially viable biobased lubricants. The book is divided into five sections that cover advanced environmentally friendly base oils and feedstocks, biobased hydraulic lubricants and biodegradability, chemically/enzymatically modified environmentally friendly base oils, vegetable oil–based environmentally friendly fluids, and additives for environmentally friendly fluids.




Statistical Analysis of Ecotoxicity Studies


Book Description

A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.




Biodegradation, Pollutants and Bioremediation Principles


Book Description

This book presents a broad compendium of biodegradation research and discussions on the most up-to-date bioremediation strategies. The most relevant microbiological, biochemical and genetic concepts are presented alongside the fundamentals of bioremediation. The topics include: a wide variety of contaminant impacts evaluation, key methodologies required to measure biodegradation and propose new bioremediation protocols, as well as the handling of microbial communities related to such processes. The selected collaborating authors are renowned for their microbiology expertise and will provide an in-depth reference for students and specialists. The contents provide a valuable source of information for researchers, professionals, and policy makers alike.




Chemometrics and Cheminformatics in Aquatic Toxicology


Book Description

CHEMOMETRICS AND CHEMINFORMATICS IN AQUATIC TOXICOLOGY Explore chemometric and cheminformatic techniques and tools in aquatic toxicology Chemometrics and Cheminformatics in Aquatic Toxicology delivers an exploration of the existing and emerging problems of contamination of the aquatic environment through various metal and organic pollutants, including industrial chemicals, pharmaceuticals, cosmetics, biocides, nanomaterials, pesticides, surfactants, dyes, and more. The book discusses different chemometric and cheminformatic tools for non-experts and their application to the analysis and modeling of toxicity data of chemicals to various aquatic organisms. You’ll learn about a variety of aquatic toxicity databases and chemometric software tools and webservers as well as practical examples of model development, including illustrations. You’ll also find case studies and literature reports to round out your understanding of the subject. Finally, you’ll learn about tools and protocols including machine learning, data mining, and QSAR and ligand-based chemical design methods. Readers will also benefit from the inclusion of: A thorough introduction to chemometric and cheminformatic tools and techniques, including machine learning and data mining An exploration of aquatic toxicity databases, chemometric software tools, and webservers Practical examples and case studies to highlight and illustrate the concepts contained within the book A concise treatment of chemometric and cheminformatic tools and their application to the analysis and modeling of toxicity data Perfect for researchers and students in chemistry and the environmental and pharmaceutical sciences, Chemometrics and Cheminformatics in Aquatic Toxicology will also earn a place in the libraries of professionals in the chemical industry and regulators whose work involves chemometrics.




Human and Ecological Risk Assessment


Book Description

Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.




Ecotoxicology of Nanoparticles in Aquatic Systems


Book Description

The use of nanoparticles in medicine, industrial, and other applications has triggered an interest in their potential. This book explores the use of nanoparticles related to their occurrence in the environment, their impact on biota in aquatic systems, application of new methodologies, and changes associated with new global scenarios. The book also covers the bioaccumulation and internalization of nanoparticles as key aspects to assess their uptake and discusses the methodologies for testing ENPs ecotoxicity at different trophic levels.