OECD Guidelines for Testing of Chemicals


Book Description




OECD Guidelines for the Testing of Chemicals OECD Guidelines for the Testing of Chemicals Twelfth Addendum - January 2001


Book Description

The OECD Guidelines for the Testing of Chemicals are a collection of the most relevant internationally agreed testing methods used by government, industry and independent laboratories when testing the safety of new and existing chemicals as well as ...




OECD Guidelines for the Testing of Chemicals OECD Guidelines for the Testing of Chemicals Fifteenth Addendum - 2004


Book Description

The OECD Guidelines for the Testing of Chemicals are a collection of internationally agreed methods for testing the safety of chemicals and chemical preparations, including pesticides and industrial chemicals. This 2005 update contains 11 new and 3 revised guidelines.




OECD Guidelines for the Testing of Chemicals OECD Guidelines for the Testing of Chemicals Fourteenth Addendum - May 2002


Book Description

The OECD Guidelines for the Testing of Chemicals provide a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as the standard methods for safety testing, the OECD Guidelines for ...




Test No. 489: In Vivo Mammalian Alkaline Comet Assay


Book Description

The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.




Introduction to Environmental Toxicology


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After fifteen years and three editions, Introduction to Environmental Toxicology: Molecular Substructures to Ecological Landscapes has become a standard that defines the field of environmental toxicology, and the fourth edition is no exception. The authors take an integrated approach to environmental toxicology that emphasizes scale and context as important factors in understanding effects and management options. New in the Fourth Edition: New author, Dr. Ruth M. Sofield 8-page color insert New chapter on fate and transport of contaminants Emphasis on the use of all types of models in understanding how nature works Revised sections on synergy and atrazine toxicity Updated coverage of the analysis of impacts to populations, communities and ecosystems Enlarged risk assessment chapter with an in-depth description of a regional scale risk assessment This edition benefits from the insight of a new author, Dr. Ruth M. Sofield, who prepared the new chapter on the fate and transport of contaminants. The relationship between structure and toxicological properties has been a major theme of this book since its inception and this new chapter expands this fundamental concept to include fate and transport. In the early chapters the use of models in science is discussed and this theme carries throughout the rest of the book. So much has changed in the fifteen years since the publication of the first edition. The mid-1990s seem so long ago, when our understanding of environmental toxicology was very basic. Ecological risk assessment was in its very early stages and the consideration of the effects of toxicants on landscapes was only beginning. Computation was still hard, genes stayed put, and it was only becoming recognized that xenobiotics could have hormonal effects — developments that are taken for granted in this edition. Written by authors who teach this subject, a feature that is reflected in their straightforward style, the book provides a foundation for understanding environmental toxicology and its application.




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test


Book Description

The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study


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A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...




Mixture Toxicity


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In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an