OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure


Book Description

This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than death/moribundity is used as an endpoint, and ...




OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method


Book Description

The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...







OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure


Book Description

A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 412: Subacute Inhalation Toxicity: 28-Day Study


Book Description

This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ...







OECD Guidelines for Testing of Chemicals


Book Description




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 413: Subchronic Inhalation Toxicity: 90-day Study


Book Description

This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure


Book Description

The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ...