OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 415: One-Generation Reproduction Toxicity Study


Book Description

This Test Guideline for reproduction testing is designed to provide general information concerning the effects of a test substance (Solid, liquid, gas or vapour) on male and female reproductive performance. The test substance is administered orally ...




Test No. 443: Extended One-Generation Reproductive Toxicity Study


Book Description

This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 416: Two-Generation Reproduction Toxicity


Book Description

This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ...




Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test


Book Description

The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study


Book Description

This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...




Test No. 421: Reproduction/Developmental Toxicity Screening Test


Book Description

The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure


Book Description

A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...










OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 412: Subacute Inhalation Toxicity: 28-Day Study


Book Description

This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ...